A General Population Twin Study of the CBCL/6-18 DSM-Oriented Scales

Spatola, Chiara A. M.; Fagnani, Corrado; Pesenti‐Gritti, Paola; Ogliari, Anna; Stazi, Maria-Antonietta; Battaglia, Marco

doi:10.1097/chi.0b013e3180335b12

Cited by 65 publications

(68 citation statements)

References 26 publications

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“…Recently, we have examined the aetiological influences on the CBCL DOS as defined by Achenbach and Rescorla [2] in twins belonging to the Italian Registry by quantitative ML approach; our results show that the phenotypic variance of the new DOS scales is explained by only additive genetic and unique environmental agents. Moreover, heritability estimates were in general higher for the DOS than for the 'classical' CBCL scales [49].…”

Section: Introductionmentioning

confidence: 99%

“…This study is based on the responses provided to the CBCL 6/18 by parents of children belonging in the Italian Twin Registry (ITR), a database including all possible twins in the Italian population [50], from which subjects aged 8-17 years, living in the industrialized province of Milan and in the suburban province of Lecco were sampled for psychometric studies of different nature and aims [35,36,49]. The recruitment methods and the socio-demographic characteristics are reported in detail elsewhere [36,49].…”

Section: Participantsmentioning

confidence: 99%

“…While the quantitative maximum-likelihood (ML) approach we employed to explore the causal structure of the DOS [49] is the most commonly employed to investigate the aetiology of individual differences within the normal range of variation, the particular mix of genetic and environmental influences on extreme scores may be substantially different [40,42]. Thus, methods that specifically examine the aetiology of extremes are clinically important so that the most appropriate inferences may be made for levels of psychopathology that portend psychiatric disorder.…”

Section: Introductionmentioning

confidence: 99%

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Genetic and environmental influences upon the CBCL/6-18 DSM-oriented scales: similarities and differences across three different computational approaches and two age ranges

Spatola

Rende

Battaglia

2010

Eur Child Adolesc Psychiatry

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To cite this version:Chiara A. M. Spatola, Richard Rende, Marco Battaglia. Genetic and environmental influences upon the CBCL/6-18 DSM-oriented scales: similarities and differences across three different computational approaches and two age ranges. European child & adolescent psychiatry, 2010, 19 (8), pp.647-658. <10.1007/s00787-010-0102-z>. ORIGINAL CONTRIBUTIONGenetic and environmental influences upon the CBCL/6-18 DSM-oriented scales: similarities and differences across three different computational approaches and two age ranges Abstract Inasmuch as the newly established DSM-oriented CBCL/6-18 scales are to be increasingly employed to assess clinical/high-risk populations, it becomes important to explore their aetiology both within the normal-and the extreme range of variation in general population samples and to compare the results obtained in different age groups. We investigated by the Quantitative Maximum Likelihood, the De Fries-Fulker, and the Ordinal Maximum Likelihood methods the genetic and environmental influences upon the five DSM-oriented CBCL/6-18 scales in 796 twins aged 8-17 years belonging to the general population-based Italian Twin Registry. When children were analysed together regardless of age, most best-fitting solutions yielded genetic and non-shared environmental factors as the sole influences for DSMoriented CBCL/6-18 behaviours, both for the normal and the extreme variations. When analyses were conducted separately for two age groups, shared environmental influences emerged consistently for Affective and Anxiety Problems in children aged 8-11. Oppositional-Defiant, Attention Deficit/Hyperactivity, and Conduct Problems appeared-with few exceptions-influenced only by genetic and non-shared environmental factors in both age groups, according to all three computational approaches. The De Fries-Fulker method appeared to be more sensitive in detecting shared environmental effects. Analysing the same set of data with different analytic approaches leads to better-balanced views on the aetiology of psychopathological behaviours in the developmental years.

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Section: Introductionmentioning

confidence: 99%

Section: Participantsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Genetic and environmental influences upon the CBCL/6-18 DSM-oriented scales: similarities and differences across three different computational approaches and two age ranges

Spatola

Rende

Battaglia

2010

Eur Child Adolesc Psychiatry

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“…Recent twin multivariate genetic epidemiological analyses in the Italian general population showed that compared with the classic CBCL/6-18 empirical subscales, the DOSs have higher heritability (lowest 0.56 and 0.61 for attention deficit/hyperactivity problems and oppositional defiant problems; highest 0.71 for conduct problems), and simpler causal structure, in that the phenotypic variance is satisfactorily explained by additive genetic and unique environmental factors only [48]. Moreover, the covariation of DOS scales can best be attributed to one common genetic factor and to two idiosyncratic environmental factors, each loading differently on the internalizing (anxiety and affective problems) and the externalizing (attention-deficit/hyperactivity, oppositional defiant, and conduct problems).…”

Section: Behavioural Assessmentmentioning

confidence: 99%

“…Compared to the classic CBCL 6/18 empirical subscales, the newly established CBCL 6/18 DSM-Oriented Scales (DOS) system have higher heritability and simpler causal structure, in that the phenotypic variance can be satisfactorily explained by additive genetic and unique environmental factors only [48].…”

Section: Introductionmentioning

confidence: 99%

COMT Val158Met polymorphism and socioeconomic status interact to predict attention deficit/hyperactivity problems in children aged 10–14

Nobile

Rusconi

Bellina

et al. 2009

Eur Child Adolesc Psychiatry

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The functional Val158Met COMT polymorphism appears to affect a host of behaviours mediated by the pre-frontal cortex, and has been found associated to the risk for disruptive behaviours including ADHD. Parental socioeconomic status (SES) has also been reported as a predictor for the same childhood disorders. In a general population sample of 575 Italian pre-adolescents aged 10-14, we examined the association of the functional Val158Met COMT polymorphism and SES-both as linear and interactive effects-with oppositional defiant problems, conduct problems, and attention deficit/hyperactivity problems, as defined by the newly established Child Behaviour Check-List/6-18 DSM oriented scales. Multivariate-and subsequent univariate-analysis of covariance showed a significant association of COMT 9 SES interaction with CBCL 6/18 DOS attention deficit/hyperactivity problems (p = 0.004), and revealed higher scores among those children with Val/Val COMT genotype who belonged to low-SES families. We also found a significant association of SES with attention deficit/hyperactivity problems and conduct problems DOS (p = 0.04 and 0.01, respectively). Our data are consistent with a bulk of recent literature suggesting a role of environmental factors in moderating the contribution of specific genetic polymorphisms to human variability in ADHD. While future investigations will refine and better clarify which specific environmental and genetic mechanisms are at work in influencing the individual risk to ADHD in pre-adolescence, these data may contribute to identify/prevent the risk for ADHD problems in childhood.

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Genetic and environmental influences on the relationship between ADHD symptoms and internalizing problems: A Chinese twin study

Chen

Wang

et al. 2015

American J of Med Genetics Pt B

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Several twin studies have investigated the overlap between attention deficit hyperactivity disorder (ADHD) and externalizing problems; however, limited information is known regarding the genetic and environmental contribution to the overlap between ADHD and internalizing problems. This study examined the genetic and environmental influences on the variation in and covariation between ADHD symptoms and internalizing problems by using the Child Behavior Checklist (CBCL). We investigated 1,316 child and adolescent twins, including 780 monozygotic twins and 536 dizygotic twins, aged 6 years to 18 years from the Chinese Child and Adolescent Twin Registry. ADHD symptoms and internalizing problems were quantified through parent rating by using the Attention Problems Scale and other three scales, which include Anxious/Depressed, Withdrawn, and Somatic Complaints of CBCL. Genetic and environmental susceptibilities common to ADHD symptoms and internalizing problems were examined through bivariate twin modeling. Results showed that genetic factors substantially influenced the ADHD symptoms with a heritability of 72%. Modest genetic influences and substantial shared environmental influences (20-77%) were observed in the three internalizing problem scales. Common genetic and shared environmental influences were essential for the overlap between ADHD and the three internalizing problems respectively. Approximately one-fifth of the genetic variance of ADHD symptoms was shared with anxiety/depression. In conclusion, substantial genetic and shared environmental influences on ADHD symptoms and internalizing problems were observed in Chinese children and adolescents. Our finding supports a common etiology between ADHD and internalizing problems. This finding can also help explain the coexistence of these behavior problems.

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A General Population Twin Study of the CBCL/6-18 DSM-Oriented Scales

Cited by 65 publications

References 26 publications

Genetic and environmental influences upon the CBCL/6-18 DSM-oriented scales: similarities and differences across three different computational approaches and two age ranges

Genetic and environmental influences upon the CBCL/6-18 DSM-oriented scales: similarities and differences across three different computational approaches and two age ranges

COMT Val158Met polymorphism and socioeconomic status interact to predict attention deficit/hyperactivity problems in children aged 10–14

Genetic and environmental influences on the relationship between ADHD symptoms and internalizing problems: A Chinese twin study

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