PLoS ONE volume 9, issue 5, Pe98432 2014 DOI: 10.1371/journal.pone.0098432 View full text
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Changwei Li, Xueli Yang, Jiang He, James E. Hixson, Dongfeng Gu, Dabeeru C. Rao, Lawrence C. Shimmin, Jianfeng Huang, Charles C. Gu, Jichun Chen, Jianxin Li, Tanika N. Kelly

Abstract: BackgroundSerum and glucocorticoid regulated kinase (SGK) plays a critical role in the regulation of renal sodium transport. We examined the association between SGK genes and salt sensitivity of blood pressure (BP) using single-marker and gene-based association analysis.MethodsA 7-day low-sodium (51.3 mmol sodium/day) followed by a 7-day high-sodium intervention (307.8 mmol sodium/day) was conducted among 1,906 Chinese participants. BP measurements were obtained at baseline and each intervention using a random…

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