Abstract:Organismal physiology is widely regulated by the circadian clock, a molecular circuit composed of a Transcription-Translation Feedback Loop 1,2. Protein components of the molecular clock are enriched in intrinsically disordered regions, inherently flexible regions that interact with other proteins via short linear binding motifs (SLiMs) 3–5. SLiM-driven interactions contribute to circadian timing and the circadian regulation of the cell. However, the mechanism that allows the formation of dynamic clock complex… Show more
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