A Functional Antagonistic Relationship between Auxin and Mitochondrial Retrograde Signaling Regulates <i>Alternative Oxidase1a</i> Expression in Arabidopsis

Ivanova, Aneta; Law, Simon R.; Narsai, Reena; Duncan, Owen; Lee, Jae Hoon; Zhang, B.; Aken, Olivier Van; Radomiljac, Jordan D.; Merwe, Margaretha van der; Yi, Keke; Whelan, James

doi:10.1104/pp.114.237495

Cited by 95 publications

(105 citation statements)

References 111 publications

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“…Additionally, aox1a:rpoTmp mutants showed some of the changes in auxin-associated genes that are involved in stress responses (Supplemental Fig. S4; Ivanova et al, 2014), particularly for genes involved in auxin transport and conjugation.…”

Section: Specific Regulation Of Gene Expression and The Mitochondrialmentioning

confidence: 99%

“…It has been observed by a number of studies that altered auxin signaling (i.e. suppression) seems to accompany mitochondrial perturbation (Tognetti et al, 2010(Tognetti et al, , 2012Ivanova et al, 2014;Kerchev et al, 2014). An examination of transcript changes for genes involved in auxin metabolism revealed several common changes in auxin efflux and influx proteins, auxin conjugation, and auxin-responsive proteins and transcription factors (Supplemental Fig.…”

Section: Specific Regulation Of Gene Expression and The Mitochondrialmentioning

confidence: 99%

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Decreasing Electron Flux through the Cytochrome and/or Alternative Respiratory Pathways Triggers Common and Distinct Cellular Responses Dependent on Growth Conditions

et al. 2014

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Diverse signaling pathways are activated by perturbation of mitochondrial function under different growth conditions. Mitochondria have emerged as an important organelle for sensing and coping with stress in addition to being the sites of important metabolic pathways. Here, responses to moderate light and drought stress were examined in different Arabidopsis (Arabidopsis thaliana) mutant plants lacking a functional alternative oxidase (alternative oxidase1a [aox1a]), those with reduced cytochrome electron transport chain capacity (T3/T7 bacteriophage-type RNA polymerase, mitochondrial, and plastidial [rpoTmp]), and double mutants impaired in both pathways (aox1a:rpoTmp). Under conditions considered optimal for growth, transcriptomes of aox1a and rpoTmp were distinct. Under adverse growth conditions, however, transcriptome changes in aox1a and rpoTmp displayed a highly significant overlap and were indicative of a common mitochondrial stress response and downregulation of photosynthesis. This suggests that the role of mitochondria to support photosynthesis is provided through either the alternative pathway or the cytochrome pathway, and when either pathway is inhibited, such as under environmental stress, a common, dramatic, and succinct mitochondrial signal is activated to alter energy metabolism in both organelles. aox1a:rpoTmp double mutants grown under optimal conditions showed dramatic reductions in biomass production compared with aox1a and rpoTmp and a transcriptome that was distinct from aox1a or rpoTmp. Transcript data indicating activation of mitochondrial biogenesis in aox1a:rpoTmp were supported by a proteomic analysis of over 200 proteins. Under optimal conditions, aox1a: rpoTmp plants seemed to switch on many of the typical mitochondrial stress regulators. Under adverse conditions, aox1a:rpoTmp turned off these responses and displayed a biotic stress response. Taken together, these results highlight the diverse signaling pathways activated by the perturbation of mitochondrial function under different growth conditions.

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Section: Specific Regulation Of Gene Expression and The Mitochondrialmentioning

confidence: 99%

Section: Specific Regulation Of Gene Expression and The Mitochondrialmentioning

confidence: 99%

Decreasing Electron Flux through the Cytochrome and/or Alternative Respiratory Pathways Triggers Common and Distinct Cellular Responses Dependent on Growth Conditions

et al. 2014

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“…Interestingly, ftsh4 plants also accumulated salicylic acid, suggesting plant mitochondrial signaling is linked to hormonal regulation at several levels. It appears that the constant balancing act between fast growth during optimal conditions and reduced growth/stress response during challenging conditions may be achieved by antagonistic relationships between for instance auxin (growth promoting) and MRR (stress-response promoting; Ivanova et al, 2014;Kerchev et al, 2014).…”

Section: Auxinmentioning

confidence: 99%

Mitochondrial Energy Signaling and Its Role in the Low-Oxygen Stress Response of Plants

et al. 2018

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ORCID IDs: 0000-0001-5369-7911 (S.W.); 0000-0003-4024-968X (O.V.A.); 0000-0003-0796-8308 (M.S.).Cells of complex organisms typically rely on mitochondria for energy provision. The amount of energy required to sustain cellular activity can vary strongly depending on external conditions. Vice versa, constraints on respiratory activity due to metabolic status or stress insult require mitochondrial signaling to coordinate cellular physiology with the function of the organelle. In this update, we review recent insights into plant mitochondrial energy signaling in the light of their significance to stress acclimation. First, we focus on the characteristic adjustments of the nuclear transcriptome that occur after pharmacological inhibition of the mitochondrial electron transport chain as the output of mitochondrial retrograde signaling. Second, we discuss the proteins that have recently been identified as regulators of the transcript responses and the emerging picture of their action as a signaling network. We then pose the question of how well our current models of inducing mitochondrial dysfunction relate to conditions that plants face naturally. We reason that low-oxygen stress shows striking similarities with electron transport inhibitors with respect to their impact on mitochondrial energy physiology upstream, as well as the cellular transcriptomic response. Finally, we highlight and discuss changes in mitochondrial physiology that are common to both stimuli as candidates for upstream signals. The aim of this update is to better define the physiological context in which mitochondrial signaling operates to provide new directions for future research. RESPONSES TO MITOCHONDRIAL ENERGY SIGNALING AT THE TRANSCRIPT LEVEL

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“…Many factors involved in the transcriptional regulation of MRR have been identified and belong to a range of functional classes, including transcription factors (NAC, WRKY, ABI4) and cyclin-dependent kinases (Ng et al, 2014). Also, an antagonistic relationship between auxin and retrograde signaling has been shown in a variety of mutant backgrounds (including PIN1, BIG, and AS1; Ivanova et al, 2014). Surprisingly, MRR mediators ANAC013 and ANAC017 are bound to the ER Ng et al, 2013).…”

Section: Mtros and Retrograde Signalingmentioning

confidence: 99%

The Roles of Mitochondrial Reactive Oxygen Species in Cellular Signaling and Stress Response in Plants

et al. 2016

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A Functional Antagonistic Relationship between Auxin and Mitochondrial Retrograde Signaling Regulates Alternative Oxidase1a Expression in Arabidopsis

Cited by 95 publications

References 111 publications

Decreasing Electron Flux through the Cytochrome and/or Alternative Respiratory Pathways Triggers Common and Distinct Cellular Responses Dependent on Growth Conditions

Decreasing Electron Flux through the Cytochrome and/or Alternative Respiratory Pathways Triggers Common and Distinct Cellular Responses Dependent on Growth Conditions

Mitochondrial Energy Signaling and Its Role in the Low-Oxygen Stress Response of Plants

The Roles of Mitochondrial Reactive Oxygen Species in Cellular Signaling and Stress Response in Plants

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