A Fully Integrated 16-Channel Closed-Loop Neural-Prosthetic CMOS SoC With Wireless Power and Bidirectional Data Telemetry for Real-Time Efficient Human Epileptic Seizure Control

Cheng, Cheng-Hsiang; Tsai, Ping-Yuan; Yang, Tzong–Jer; Cheng, Wan-Hsueh; Yen, Ting-Yang; Luo, Zhicong; Qian, Xin-Hong; Chen, Zhuo; Lin, Tzu-Han; Chen, Weihong; Chen, Wei-Ming; Liang, Sheng-Fu; Shaw, Fu-Zen; Chang, Cheng-Chen; Hsin, Yue-Loong; Lee, Chen‐Yi; Ker, Ming‐Dou; Wu, Chung-Yu

doi:10.1109/jssc.2018.2867293

Cited by 106 publications

(37 citation statements)

References 26 publications

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“…Due to its superior power output and battery‐level energy density, the LNVOPF//Nb 2 O 5 device could be used in commercial Deep Brain Stimulators (DBS), which treat neurological disorders (Parkinson's disease and epilepsy). The use of DBS has been validated as a better treatment, without side effects, compared to conventional drug therapies …”

Section: Introductionsupporting

confidence: 73%

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Designing the Charge Storage Properties of Li‐Exchanged Sodium Vanadium Fluorophosphate for Powering Implantable Biomedical Devices

Lai

Ashby

Bashian

et al. 2019

Advanced Energy Materials

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The growing demand for bioelectronics has generated widespread interest in implantable energy storage. These implantable bioelectronic devices, powered by a complementary battery/capacitor system, have faced difficulty in miniaturization without compromising their functionality. This paper reports on the development of a promising high‐rate cathode material for implantable power sources based on Li‐exchanged Na1.5VOPO4F0.5 anchored on reduced graphene oxide (LNVOPF‐rGO). LNVOPF is unique in that it offers dual charge storage mechanisms, which enable it to exhibit mixed battery/capacitor electrochemical behavior. In this work, electrochemical Li‐ion exchange of the LNVOPF structure is characterized by operando X‐ray diffraction. Through designed nanostructuring, the charge storage kinetics of LNVOPF are improved, as reflected in the stored capacity of 107 mAh g−1 at 20C. A practical full cell device composed of LNVOPF and T‐Nb2O5, which serves as a pseudocapacitive anode, is fabricated to demonstrate not only high energy/power density storage (100 Wh kg−1 at 4000 W kg−1) but also reliable pulse capability and biocompatibility, a desirable combination for applications in biostimulating devices. This work underscores the potential of miniaturizing biomedical devices by replacing a conventional battery/capacitor couple with a single power source.

show abstract

Section: Introductionsupporting

confidence: 73%

“…The b‐value reveals a clear size dependence, increasing from 0.5 for the micronbrick to nearly 0.8 for the nanoparticle. This indicates the charge storage mechanism transitioned from a diffusion‐controlled process to a partially surface‐controlled one by simple size reduction …”

Section: Resultsmentioning

confidence: 99%

Designing the Charge Storage Properties of Li‐Exchanged Sodium Vanadium Fluorophosphate for Powering Implantable Biomedical Devices

Lai

Ashby

Bashian

et al. 2019

Advanced Energy Materials

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“…An eight-channel closed-loop SoC was also implemented in an acquisition circuit, a wireless interface with coil, an antropy-spectrum algorithm, and a waveform-fixed electrical stimulator [9]. A 16-channel SoC was also proposed with the mini-pig in vivo testing [10]. A 32/64-channel SoC was also proposed by R. Genov et al, including adaptive-input-range sensing channels, a CPU-embedded support vector machine (SVM)-based algorithm, and a controllable electrical stimulator [11]- [13].…”

Section: Introductionmentioning

confidence: 99%

A Programmable EEG Monitoring SoC with Optical and Electrical Stimulation for Epilepsy Control

et al. 2020

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In this paper, a cross-domain integration system composed of a gene transfer technique with a pre-clinical trial, an on-chip circuit design, an off-chip hardware with peripheral unit integration, and a custom software is presented. Opsin protein-gene transfer is successfully conducted to demonstrate that gene transfer treatment with optical stimulation has several benefits compared with electrical treatment. The proposed wireless programmable stimulating system on chip (WPSSoC) is composed of two sensing channels combined with a decimation filter to acquire intracranial electroencephalography (iEEG), an epilepsy detection unit (EDU), a stimulator with a waveform controller, and an ultra-low-power embedded transceiver. The equivalent sample rate of sensed data is 375 samples/s with 16-bit output data. The performance of intermodulation distortion with a third order (IMD 3) is approximately 68 dB. The EDU extracts approximate entropy (ApEn) and spectrum bins for the classifier. The stimulator with controller features on the waveform-adjustable function to provide 0-510 µA of electrical stimulation and 0-50 mW of optical stimulation. The proposed transceiver is implemented with a 2.45 GHz on-off keying (OOK) carrier frequency. Transmitter and receiver front-ends perform at 50.6 and 12.7 pJ/bit of energy per bit, respectively. Power consumption and area of WPSSoC are about 1 mW and 13.67 mm 2 in a 0.18 µm process, respectively. Circuits of each part are integrated in a 4.3 cm × 2 cm printed circuit board. The shrunk device is verified with Thy1-ChR2-YFP gene transfer in C57BL/6 mice by using a custom software which is used to provide commands and monitor iEEG. INDEX TERMS ChR2 gene transferring, electrical stimulation, epilepsy, implantable device, in vivo testing, open-/closed-loop control, optical stimulation, system-on-chip, wireless monitoring and control.

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“…Key recent applications have included research tools for studying the brain (e.g. electrophysiology) [1]- [5], brain machine interfaces (BMIs) [6]- [8] and closed-loop neuromodulation [9]- [11]. The new feature in such devices is the ability to record, and subsequently detect and decode neural activity.…”

Section: Introductionmentioning

confidence: 99%

A 300 Mbps 37 pJ/bit UWB-Based Transcutaneous Optical Biotelemetry Link

Marcellis

Stanchieri

Faccio

et al. 2020

IEEE Trans. Biomed. Circuits Syst.

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This paper reports an implantable transcutaneous telemetry for a brain machine interface that uses a novel optical communication system to achieve a highly energy-efficient link. Based on an pulse-based coding scheme, the system uses subnanosecond laser pulses to achieve data rates up to 300 Mbps with relatively low power levels when compared to other methods of wireless communication. This has been implemented using a combination of discrete components (semiconductor laser and driver, fast-response Si photodiode and interface) integrated at board level together with reconfigurable logic (encoder, decoder and processing circuits implemented using Xilinx KCU105 board with Kintex UltraScale FPGA). Experimental validation has been performed using a tissue sample that achieves representative level of attenuation/scattering (porcine skin) in the optical path. Results reveal that the system can operate at data rates up to 300 Mbps with a bit error rate (BER) of less than 10-10 , and an energy efficiency of 37 pJ/bit. This can communicate, for example, 1,024 channels of broadband neural data sampled at 18 kHz, 16bit with only 11 mW power consumption.

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A Fully Integrated 16-Channel Closed-Loop Neural-Prosthetic CMOS SoC With Wireless Power and Bidirectional Data Telemetry for Real-Time Efficient Human Epileptic Seizure Control

Cited by 106 publications

References 26 publications

Designing the Charge Storage Properties of Li‐Exchanged Sodium Vanadium Fluorophosphate for Powering Implantable Biomedical Devices

Designing the Charge Storage Properties of Li‐Exchanged Sodium Vanadium Fluorophosphate for Powering Implantable Biomedical Devices

A Programmable EEG Monitoring SoC with Optical and Electrical Stimulation for Epilepsy Control

A 300 Mbps 37 pJ/bit UWB-Based Transcutaneous Optical Biotelemetry Link

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