A Fluorescein and Indocyanine Green Angiographic Study of Choriocapillaris in Age-related Macular Disease

Abstract

To examine the phenomenon of a prolonged choroidal filling phase (PCFP) as seen on fluorescein and indocyanine green (ICG) angiography in patients with early age-related macular disease (AMD). Methods: One hundred eyes of consecutive patients with early AMD were studied. Patchy and slow choroidal filling in early fluorescein and distinct areas of reduced choroidal fluorescence in ICG angiography were interpreted as PCFP. In addition, associated drusen characteristics and the AMD status of the fellow eye were recorded. Results: A PCFP was observed in 26% of eyes using fluorescein and 32% of eyes using ICG angiography, with good concordance between findings using both techniques (= 0.9). A PCFP was associated with confluent drusen

Microglia Contribution to the Regulation of the Retinal and Choroidal Vasculature in Age-Related Macular Degeneration

“…With distinct approaches, several studies demonstrated the association between choroidal vascular changes with ageing and early AMD. Fluorescein angiography showed a prolonged choroidal filling phase in patients with early AMD [108], which is in agreement with the observations of reduced choroidal perfusion caused by a change in diffusional characteristics of the Bruch's membrane [109,110]. Choroidal thickness is negatively correlated with age [111], and fluorescein angiograms show reduced blood volume and abnormal blood flow in eyes with nonexudative AMD [90,112].…”

Microglia Contribution to the Regulation of the Retinal and Choroidal Vasculature in Age-Related Macular Degeneration

“…With distinct approaches, several studies demonstrated the association between choroidal vascular changes with ageing and early AMD. Fluorescein angiography showed a prolonged choroidal filling phase in patients with early AMD [108], which is in agreement with the observations of reduced choroidal perfusion caused by a change in diffusional characteristics of the Bruch's membrane [109,110]. Choroidal thickness is negatively correlated with age [111], and fluorescein angiograms show reduced blood volume and abnormal blood flow in eyes with nonexudative AMD [90,112].…”

Alterations of Choroidal Blood Flow Regulation in Young Healthy Subjects with Complement Factor H Polymorphism

“…Several previous studies have shown that AMD is associated with reduced choroidal blood flow [31], [32], [33], [34], [35], [36], [37]. In an experiment which used a protocol almost similar to our study a reduced regulatory capacity of the choroidal vasculature was observed in AMD patients during a squatting-induced increase in OPP [38].…”

Association of Focal Choroidal Excavation With Age-Related Macular Degeneration

“…Focal choroidal ischemia may be involved in the development of CNV. [26][27][28][29] In the current study, color fundus photographs showed pigmentary disturbances in nine excavations. Focal damage of the RPE and Bruch's membrane due to the excavation may contribute to the development of CNV.…”

Microglia Contribution to the Regulation of the Retinal and Choroidal Vasculature in Age-Related Macular Degeneration

“…With distinct approaches, several studies demonstrated the association between choroidal vascular changes with ageing and early AMD. Fluorescein angiography showed a prolonged choroidal filling phase in patients with early AMD [108], which is in agreement with the observations of reduced choroidal perfusion caused by a change in diffusional characteristics of the Bruch's membrane [109,110]. Choroidal thickness is negatively correlated with age [111], and fluorescein angiograms show reduced blood volume and abnormal blood flow in eyes with nonexudative AMD [90,112].…”

Alterations of Choroidal Blood Flow Regulation in Young Healthy Subjects with Complement Factor H Polymorphism

“…Several previous studies have shown that AMD is associated with reduced choroidal blood flow [31], [32], [33], [34], [35], [36], [37]. In an experiment which used a protocol almost similar to our study a reduced regulatory capacity of the choroidal vasculature was observed in AMD patients during a squatting-induced increase in OPP [38].…”

Association of Focal Choroidal Excavation With Age-Related Macular Degeneration

“…Focal choroidal ischemia may be involved in the development of CNV. [26][27][28][29] In the current study, color fundus photographs showed pigmentary disturbances in nine excavations. Focal damage of the RPE and Bruch's membrane due to the excavation may contribute to the development of CNV.…”

Microglia Contribution to the Regulation of the Retinal and Choroidal Vasculature in Age-Related Macular Degeneration

“…With distinct approaches, several studies demonstrated the association between choroidal vascular changes with ageing and early AMD. Fluorescein angiography showed a prolonged choroidal filling phase in patients with early AMD [108], which is in agreement with the observations of reduced choroidal perfusion caused by a change in diffusional characteristics of the Bruch's membrane [109,110]. Choroidal thickness is negatively correlated with age [111], and fluorescein angiograms show reduced blood volume and abnormal blood flow in eyes with nonexudative AMD [90,112].…”

Alterations of Choroidal Blood Flow Regulation in Young Healthy Subjects with Complement Factor H Polymorphism

“…Several previous studies have shown that AMD is associated with reduced choroidal blood flow [31], [32], [33], [34], [35], [36], [37]. In an experiment which used a protocol almost similar to our study a reduced regulatory capacity of the choroidal vasculature was observed in AMD patients during a squatting-induced increase in OPP [38].…”

Association of Focal Choroidal Excavation With Age-Related Macular Degeneration

“…Focal choroidal ischemia may be involved in the development of CNV. [26][27][28][29] In the current study, color fundus photographs showed pigmentary disturbances in nine excavations. Focal damage of the RPE and Bruch's membrane due to the excavation may contribute to the development of CNV.…”