2019
DOI: 10.4314/tjpr.v18i2.19
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Abstract: Purpose: To develop a chromatographic method for the determination of deferoxamine (DFX) and Dpenicillamine (D-PEN) by improving ultra violet (UV)-absorption via complex formation with Fe 2+ and Cu 2+ metal ions. Methods: Chromatographic analysis was performed by Waters RP-HPLC system using a Symmetry® C (18) column with a mobile phase comprising 0.1 % formic acid and methanol (95:5 v/v). For complexation process, drug and metal ion solution were mixed in a ratio of 1:5 and the resulting complex directly analy… Show more

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Cited by 6 publications
(5 citation statements)
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“…All available flow rates were studied for the system and that shows the best flow rate for (D-PEN-NQS) FIA system was 12.77 mL.min -1 with sample through-put about 103 sample.hour -1 as shown in Figure (11) the sampling rate was calculated depending on the time required for loading the drug, and the reagent to loops of the seven three-way valve plus the time required to maximum peak height appear (this time was found to be 22 s) in addition to 13 s required for loading drug, buffer and reagent, so the sampling rate was 103 sample.hour -1 for the developed FIA system.…”
Section: Effect Of Optimum Total Flow Rate and Sample Through-putmentioning
confidence: 99%
See 1 more Smart Citation
“…All available flow rates were studied for the system and that shows the best flow rate for (D-PEN-NQS) FIA system was 12.77 mL.min -1 with sample through-put about 103 sample.hour -1 as shown in Figure (11) the sampling rate was calculated depending on the time required for loading the drug, and the reagent to loops of the seven three-way valve plus the time required to maximum peak height appear (this time was found to be 22 s) in addition to 13 s required for loading drug, buffer and reagent, so the sampling rate was 103 sample.hour -1 for the developed FIA system.…”
Section: Effect Of Optimum Total Flow Rate and Sample Through-putmentioning
confidence: 99%
“…Several methods have been reported for the determination of D-PEN in pharmaceutical dosage forms including kinetic spectrophotometry [5], electrochemical chiral sensor [6], Flow-injection [7], Circular dichroism spectroscopy [8], spectrofluorimetric [9], Fluorometric sensor [10], HPLC [11,12], carbon paste electrode [13], HPLC-FLD and CE-LIF [14], spectrophotometric [15,16], potentiometric [17], fluorescence [18][19][20], Electrochemical sensor [21], Electrocatalytic [22], Chemiluminescence [23] and Voltametric [24].…”
Section: Introductionmentioning
confidence: 99%
“…Efficient and selective analytical methods for HA determination in plasma and urine samples are required for both dose regulation and clinical studies (pharmacokinetic–pharmacodynamic parameters, efficiency of the drugs) [ 6 , 7 ]. Up to date, several analytical methods have been used for HA determination: chromatographic [ 5 , 6 , 7 , 8 , 9 ], electrochemical [ 10 , 11 ], and spectrophotometric [ 12 , 13 ]. Some of the procedures are based on complexes formation between HA and metals [ 9 , 13 ].…”
Section: Introductionmentioning
confidence: 99%
“…Up to date, several analytical methods have been used for HA determination: chromatographic [ 5 , 6 , 7 , 8 , 9 ], electrochemical [ 10 , 11 ], and spectrophotometric [ 12 , 13 ]. Some of the procedures are based on complexes formation between HA and metals [ 9 , 13 ]. No on-site procedures, including the use of sensor materials, have been described to date for HA determination.…”
Section: Introductionmentioning
confidence: 99%
“…It is suggested that the effectiveness of vitamin C as a supplement to standard iron chelation therapy be evaluated by suitable dosage, duration and route of administration, and by undergoing combination therapy with vitamin C for better monitoring of body iron overload. 14 So far, several methods such as atomic absorption spectrometry, 17,18 HPLC, [19][20][21] differential pulse polarography, [22][23][24] micellar vs reversed phase liquid chromatography, 25 spectrophotometric method, 16 direct titration 26 have been used to separately determine deferoxamine and vitamin C, which is presently the most clinically useful iron chelating agent.…”
mentioning
confidence: 99%