2021
DOI: 10.3389/fgene.2021.639858
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Abstract: Glioma is the most common and malignant primary brain tumor. Patients with malignant glioma usually have a poor prognosis due to drug resistance and disease relapse. Cancer stem cells contribute to glioma initiation, progression, resistance, and relapse. Hence, quick identification and efficient understanding of glioma stem cells (GSCs) are of profound importance for therapeutic strategies and outcomes. Ideally, therapeutic approaches will only kill cancer stem cells without harming normal neural stem cells (N… Show more

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Cited by 3 publications
(5 citation statements)
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“…Identifying the differences between normal NSCs and GSCs is important for selecting potential therapeutic targets. Here, we included the GSCs cell line HXX-6 we established before 21 to observe the expression of Wif1 and DKK3 in active NSCs, quiescent-like NSCs, glioma cells (U87 and U251), and GCSs (HXX-6). Wif1 was highly expressed within quiescent-like NSCs (Fig.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Identifying the differences between normal NSCs and GSCs is important for selecting potential therapeutic targets. Here, we included the GSCs cell line HXX-6 we established before 21 to observe the expression of Wif1 and DKK3 in active NSCs, quiescent-like NSCs, glioma cells (U87 and U251), and GCSs (HXX-6). Wif1 was highly expressed within quiescent-like NSCs (Fig.…”
Section: Resultsmentioning
confidence: 99%
“…Trypsin-EDTA (0.05%; 25300062, Invitrogen) and trypsin inhibitor (R007100, Invitrogen) were used for cell passage. HXX-6 is a primary cultured glioma stem cell line established from surgical specimens, as previously described 21 .…”
Section: Methodsmentioning
confidence: 99%
“…In our study, we included both hGSCs and hNSCs from previous studies (Han et al 2017 ; Han et al 2021 ). For each cell type, we include two cell lines for RNA sequencing analysis.…”
Section: Discussionmentioning
confidence: 99%
“…hGSCs line was established from surgical specimens (Han et al 2021 ). Surgical specimens were gotten strictly according to Ethics Committee permission.…”
Section: Methodsmentioning
confidence: 99%
“…In this study, we used isolated hGSCs from surgical samples of glioma patients and the established hNSC lines to study their responses to BMP4 treatment (Han et al 2017;Han et al 2021). First, we observed the morphological changes in cells after BMP4 stimulation.…”
Section: Introductionmentioning
confidence: 99%