A facile synthesis of 4-acylamino-tetrahydroindazoles via the Ritter reaction

Regioselective Synthesis of Polyfluoroalkyl Substituted 6,7‐Dihydrobenzisoxazolones

“…Therefore, in view of these observations and in conjunction with our previous interest in synthesis of heterocyclic compounds , we report herein a facile synthesis of novel regioisomeric 6,7‐dihydro‐1,2‐benzisoxazol‐4(5 H )‐ones and 6,7‐dihydro‐2,1‐benzisoxazol‐4(5 H )‐ones with perfluoroalkyl or halogenodifluoromethyl substituents.…”

Crystal structures of two (±)-exo-N-isobornylacetamides

“…In light of the aforementioned facts, there is a vast interest in developing new synthetic protocols for the synthesis of compounds of this class and in their structural studies. We have recently reported an application of the Ritter reaction (Jiang et al, 2014) in the synthesis of amide-derivatized heterocycles (Turks et al, 2012). Hence, we identified the possibility to obtain isobornylamine derived amides (AE)-(1) and (AE)-(2) from borneol in the direct Ritter reaction.…”

6.07 Ritter-Type Reactions

“…This type of process was greatly developed by Meerwein (Scheme 40). 123 Ho has demonstrated that phenylethyl chloride initially forms a phenonium ion before producing the nitrilium intermediate (equation 59), 126 …”

“…Further reaction with trimethylsilyl polyphosphate produced the cyclic imine 46. is generally the hydroxy group that undergoes Ritter reaction in molecules where multiple functional groups are present, or where the hydroxy group comprises part of a more complex functional group. Equations 19-23 illustrate representative examples [55][56][57][58][59]. …”