A dynamical system for the IGF1-AKT signaling pathway in skeletal muscle adaptation

Villota-Narvaez, Yesid; Garzón‐Alvarado, Diego Alexander; Ramírez-Martínez, Angélica

doi:10.1016/j.biosystems.2021.104355

Cited by 6 publications

(9 citation statements)

References 37 publications

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“…a 10 and a 20 are reference values for functions a 1 (t) and a 2 (t). Values from Villota-Narvaez et al (2021).…”

Section: Resultsmentioning

confidence: 99%

“…The IGF1-AKT signaling pathway is triggered by an external stimulus; as a result, the concentration of each molecule involved in this pathway evolves producing hypertrophy or atrophy. Based on the simplified mechanism of the IGF1-AKT signaling pathway reviewed by Schiaffino and Mammucari (2011) , we developed the biochemical model presented in Villota-Narvaez et al (2021) . Our biochemical model produces the evolution of the cellular myofibril content, and it is suitable for atrophy scenarios, whereas the model presented in the present paper improves the hypertrophy results.…”

Section: Methodsmentioning

confidence: 99%

“…Table 1 shows parameters and initial conditions for the biochemical model, those values were reported in Villota-Narvaez et al (2021) . In that study, homeostatic concentrations of the molecules involved in the pathway, taken from Léger et al (2006) and Bickel et al (2005) , were normalized to the concentration of IGF1, and those values were used as initial conditions; the myofibril population was set to 1; parameters for the equation system 1 were fitted to experimental evidence on atrophy and used in this article for the hypertrophy case.…”

Section: Methodsmentioning

confidence: 99%

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Multi-scale mechanobiological model for skeletal muscle hypertrophy

et al. 2022

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Skeletal muscle adaptation is correlated to training exercise by triggering different signaling pathways that target many functions; in particular, the IGF1-AKT pathway controls protein synthesis and degradation. These two functions regulate the adaptation in size and strength of muscles. Computational models for muscle adaptation have focused on: the biochemical description of signaling pathways or the mechanical description of muscle function at organ scale; however, an interrelation between these two models should be considered to understand how an adaptation in muscle size affects the protein synthesis rate. In this research, a dynamical model for the IGF1-AKT signaling pathway is linked to a continuum-mechanical model describing the active and passive mechanical response of a muscle; this model is used to study the impact of the adaptive muscle geometry on the protein synthesis at the fiber scale. This new computational model links the signaling pathway to the mechanical response by introducing a growth tensor, and links the mechanical response to the signaling pathway through the evolution of the protein synthesis rate. The predicted increase in cross sectional area (CSA) due to an 8 weeks training protocol excellently agreed with experimental data. Further, our results show that muscle growth rate decreases, if the correlation between protein synthesis and CSA is negative. The outcome of this study suggests that multi-scale models coupling continuum mechanical properties and molecular functions may improve muscular therapies and training protocols.

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“…a 10 and a 20 are reference values for functions a 1 (t) and a 2 (t). Values from Villota-Narvaez et al (2021).…”

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Multi-scale mechanobiological model for skeletal muscle hypertrophy

et al. 2022

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“…Mitochondria are one of the most important organelles; they are distributed in myocytes and produce ATP to support the normal physiological activity of myocytes. Numerous investigations have revealed age-related mitochondrial alterations [ 38 , 48 , 49 ]. Mitochondria also play an important regulatory role in oxidative stress [ 50 ].…”

Section: Discussionmentioning

confidence: 99%

Beneficial Effects of Walnut Oligopeptides on Muscle Loss in Senescence-Accelerated Mouse Prone-8 (SAMP8) Mice: Focusing on Mitochondrial Function

Fan

Hao

et al. 2022

Nutrients

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Aging-related muscle loss is a hallmark of aging and is the cause of some negative outcomes. An optimized diet and supplements have a positive effect in slowing down the process of muscle loss. This study was designed to evaluate the beneficial effects of walnut oligopeptides (WOPs) on aging-related muscle loss and explore the possible underlying mechanism in Senescence-Accelerated Mouse Prone 8 (SAMP8) Mice. SAMP8 mice were randomly divided into four groups (n = 15/group), including one group which was the SAMP8 age control group and three groups those were WOP intervention groups. Meanwhile, Senescence Accelerated Resistant Mouse 1 (SAMR1) mice (n = 12), which had normal senescence rates, were used as model controls. During the six-month intervention period, the age control and normal control groups were given sterilized water, while the three WOP intervention groups were given WOP solution with low (110 mg/kg·bw), medium (220 mg/kg·bw) and high concentrations (440 mg/kg·bw), respectively. The results showed that WOPs could significantly increase muscle mass and improve physical performance (wire hang and catwalk behavioral tests) in aging mice. Moreover, WOPs could significantly reduce the levels of IL-1β, IL-6 and TNF-α in serum and gastrocnemius tissues and increase the mitochondrial DNA content, as well as the expression levels of AMPK, PGC-1α, NRF-1 and TFAM in the gastrocnemius muscle of aging mice, which was speculated to be the specific mechanism related to mitochondrial function improvement and inflammation reduction. These results indicate that WOPs can improve aging-related muscle loss, in term of both muscle mass and physical performance, and WOP supplements seems to be potentially effective in elderly individuals.

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“…Moreover, reports manifested that folic acid modulated the metabolism of amino acids and proteins ( Brade et al, 1972 ; Yao et al, 2013 ), and activated the Akt pathway to stimulating the myogenesis in cells ( Hwang et al, 2015 ). Mammalian target of rapamycin participates the regulation of Akt pathway ( Villota-Narvaez et al, 2021 ). Most notably, skeletal muscle growth is also coordinated by myogenic regulatory factors ( MRFs ) ( Fu et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%