A dual-step immobilization/imprinting approach to prepare magnetic molecular imprinted polymers for selective removal of human serum albumin

Application progress of magnetic molecularly imprinted polymers chemical sensors in the detection of biomarkers

“…Due to its good chemical stability and biocompatibility, SiO 2 has become the most widely applied MNPs surface modification material. According to the properties of the initiator, upon adding a suitable silane coupling agent, active functional groups such as aldehyde group, 51 vinyl group, 52,53 sulfhydryl group, 54 amino group 55,56 and hydroxyl group 57,58 can be modified on the magnetic SiO 2 . For example, Zhou et al 54 prepared hollow Fe 3 O 4 microspheres with small mass and good dispersion by hydrothermal method.…”

A UCMPs@MIL-100 based thermo-sensitive molecularly imprinted fluorescence sensor for effective detection of β-lactoglobulin allergen in milk products

“…Inspired by the "antigen and antibody binding", molecularly imprinted polymers (MIPs) have attracted much attention in the field of protein detection [ 13 ]. However, traditional MIPs have defects such as limited mass transfer capacity, poor structural rigidity, poor accessibility to target molecules and uncontrollable adsorption process, leading to a decrease in the adsorption capacity, adsorption rate and selectivity of MIPs to targets [ 14 , 15 ]. Due to the characteristics of phase transition and structural transition under temperature stimulation, thermo-sensitive MIPs have remarkable adsorption reversibility and stability, showing great potential in the field of biomolecular recognition [ 16 – 18 ].…”

Preparation of carbon-based metal organic framework-modified molecularly imprinted polymers for selective recognition of bovine hemoglobin in biological samples

“…3,4 Accurate monitoring of a high-quality biological macromolecule like BHb is challenging owing to its complex structure and uncontrollable stability, which emphasizes the need for the development of an efficient method for the separation and enrichment of BHb in complex biological samples. 5 Currently, a plethora of enrichment strategies have been developed for the separation of highly-abundant proteins, including lectin affinity, hydrophilic, and electrostatic interactions, etc. Among all, metal chelation is an advantageous method for protein purification owing to its simple preparation process, strong binding ability, and protein loading ability.…”