A double-spike MC TIMS measurement procedure for low-amount Ca isotopic analysis of limited biological tissue samples

Retzmann, Anika; Walls, Dorothy; Miller, Kerri; Irrgeher, Johanna; Prohaska, Thomas; Wieser, Michael E.

doi:10.1007/s00216-021-03650-8

Cited by 3 publications

(2 citation statements)

References 63 publications

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“…Finally the gold standard method for isotope ratio measurement, MC-TIMS, featured in a 42 Ca– 48 Ca double spike method to determine Ca isotope ratios in small tissue samples. 89 A low Ca blank of ≤10 ng, achieved through optimisation of the separation of Ca from the matrix and isobaric interferences using DGA resin, reduced the minimum mass of Ca required to 670 ng, which is equivalent to 2.3 μg bone material or 10 μL blood. The reported expanded uncertainty for the procedure for δ 44/40 Ca was 0.08‰.…”

Section: Progress With Analytical Techniquesmentioning

confidence: 99%

Atomic spectrometry update: review of advances in the analysis of clinical and biological materials, foods and beverages

Patriarca

Barlow

Cross³

et al. 2023

J. Anal. At. Spectrom.

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Section: Progress With Analytical Techniquesmentioning

confidence: 99%

Atomic spectrometry update: review of advances in the analysis of clinical and biological materials, foods and beverages

Patriarca

Barlow

Cross³

et al. 2023

J. Anal. At. Spectrom.

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“…Wu et al suggested the use of a clean laboratory environment can allow for lower detection limits [ 9 ]. Retzmann et al described in detail how to minimize the Ca background and reported that, e.g., the use of nitrile gloves and clean-room wipes were major sources of Ca contamination and should be avoided [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Low-level 40Ca determinations using nitrous oxide with reaction cell inductively coupled plasma–tandem mass spectrometry

2022

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In inductively coupled plasma mass spectrometry, the most abundant Ca isotope (40Ca) suffers from isobaric interference with argon, hindering the potential for low detection limits of Ca. A powerful approach is to remove the interference by using a reaction gas in a reaction cell. Ammonia (NH3) has proven to be an effective reaction gas by process of a charge transfer reaction. However, NH3 is highly corrosive and toxic and cannot remove isobaric 40 K. Therefore, this work proposes the use of nitrous oxide (N2O) to mass shift the target analyte 40Ca to 40Ca16O+ as a non-corrosive and non-toxic alternative. Instrument performance testing demonstrated that N2O was capable of reaching equivalent detection limits (0.015 ng g−1) and background equivalence concentrations (0.041 ng g−1) to that of NH3 and limited by the blank only. Further investigation of matrix interferences with synthetic standards highlighted that the N2O approach supports the separation of potassium (K) and magnesium (Mg)–based interferences at tested concentrations of more than 600 times and almost 800 times higher than Ca respectively, whereas NH3 was found to only support the removal of Mg. This work highlights a clear advantage of N2O for low-level Ca determinations with high matrix loads, as well as compatibility with other instrumentation sensitive to corrosion that supports reaction cell technology. Graphical abstract

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Calcium isotopic composition of widely available biological reference materials using collision cell (CC)-MC-ICP-MS

Dai

Moynier

Cui

et al. 2023

Journal of Trace Elements and Minerals

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A double-spike MC TIMS measurement procedure for low-amount Ca isotopic analysis of limited biological tissue samples

Cited by 3 publications

References 63 publications

Atomic spectrometry update: review of advances in the analysis of clinical and biological materials, foods and beverages

Atomic spectrometry update: review of advances in the analysis of clinical and biological materials, foods and beverages

Low-level 40Ca determinations using nitrous oxide with reaction cell inductively coupled plasma–tandem mass spectrometry

Calcium isotopic composition of widely available biological reference materials using collision cell (CC)-MC-ICP-MS

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