2001
DOI: 10.1002/1529-0131(200111)44:11<2686::aid-art448>3.0.co;2-h
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Abstract: Objective Colchicine is a widely used treatment for Behçet's syndrome, even though in a previous 6‐month controlled study, it was shown to be effective only in controlling erythema nodosum and arthralgias. We reassessed the effect of colchicine in Behçet's syndrome in a study conducted among a larger group of patients for 2 years. Methods We randomized 116 patients with Behçet's syndrome (60 male/56 female), who had active mucocutaneous disease without eye or major organ involvement, to receive either placebo … Show more

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Cited by 345 publications
(170 citation statements)
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References 7 publications
(11 reference statements)
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“…9,[11][12][13] Important data regarding longterm colchicine use was obtained from patients with familial Mediterranean fever and Behçet's disease. 14,15 Colchicine is known to have an effect on the pulmonary fibrotic process. Colchicine combined with prednisone has been used to treat idiopathic pulmonary fibrosis.…”
Section: Discussionmentioning
confidence: 99%
“…9,[11][12][13] Important data regarding longterm colchicine use was obtained from patients with familial Mediterranean fever and Behçet's disease. 14,15 Colchicine is known to have an effect on the pulmonary fibrotic process. Colchicine combined with prednisone has been used to treat idiopathic pulmonary fibrosis.…”
Section: Discussionmentioning
confidence: 99%
“…Así, para las úlceras orales además del tratamiento tópico con corticoides y anestésicos, la colchicina es uno de los medicamentos más empleados. Hay evidencias que apoyan su utilidad en el eritema nodoso, úlceras y artritis en mujeres y en manifestaciones articulares en hombres 15 . También para este tipo de manifestaciones se ha usado azatioprina, ciclosporina y en series aisladas talidomida y dapsona, todos con buena respuesta 1 .…”
Section: Discussionunclassified
“…También para este tipo de manifestaciones se ha usado azatioprina, ciclosporina y en series aisladas talidomida y dapsona, todos con buena respuesta 1 . En casos refractarios se han empleado fármacos con actividad anti factor de necrosis tumoral alfa (TNF-α), existiendo un estudio aleatorio con etanercept y reportes con infliximab, con buenos resultados [15][16][17][18] . En cuanto a las manifestaciones oculares, esteroides sistémicos se combinan con inmunosupresores orales, existiendo evidencias que apoyan tanto la azatioprina como la ciclosporina.…”
Section: Discussionunclassified
“…Colchicine was shown to be effective for genital ulcers and nodular lesions especially in women, but there was some controversy regarding its efficacy in oral ulcers. [6][7][8] The efficacy of colchicine and immunosuppressives for papulopustular or …”
Section: Overarching Principlesmentioning
confidence: 99%
“…Colchicine was shown to be beneficial for preventing arthritis episodes in RCTs. [6][7][8] Some members of the task force favoured the use of continuous low-dose corticosteroids in patients whose arthritis is not controlled with colchicine whereas others preferred azathioprine, interferon-alpha or TNFis. 9 29 34 41 63 96 109-111 Intra-articular glucocorticoids may be helpful during an acute monoarticular attack.…”
Section: Recommendation 9: Nervous System Involvementmentioning
confidence: 99%