Arch Dermatol
 2003
DOI: 10.1001/archderm.139.5.581
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A Double-blind Randomized Trial of 0.1% Tacrolimus vs 0.05% Clobetasol for the Treatment of Childhood Vitiligo

Verónica Lepe
1
,
Benjamín Moncada2,
Juan Pablo Castanedo-Cázares3
et al.
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Cited by 279 publications

(278 citation statements)
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“…Our results differ from Silverberg et al [17] findings, in which the response was 61% for head/neck regions and 47% for the trunk and/or extremities, as this study was performed upon children by 0.1% tacrolimus. Our results have also differed from Lepe et al [18] . They found tacrolimus produces over 75% repigmentation, mostly on facial areas.…”
Section: Discussioncontrasting
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Our results differ from Silverberg et al [17] findings, in which the response was 61% for head/neck regions and 47% for the trunk and/or extremities, as this study was performed upon children by 0.1% tacrolimus. Our results have also differed from Lepe et al [18] . They found tacrolimus produces over 75% repigmentation, mostly on facial areas.…”
Section: Discussioncontrasting
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…In our meta-analysis, we found that tacrolimus achieved excellent improvement regarding re-pigmentation in 29% of patients and moderate improvement in 26% of patients. Our results were similar to Lepe et al [ 20 ] which a quarter of patients had an excellent improvement and one-fifth had moderate improvement. The prospective cohort study of Kenwar et al [ 12 ] indicated that 60% of patients had an excellent improvement regarding re-pigmentation.…”
Section: Discussionsupporting
confidence: 92%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…The finding of tacrolimus‐induced repigmentation in a subset of patients with NSV, in our study, agreed with the results of previous RCTs whether they used tacrolimus at the same concentration of 0.03%, 16,17 or higher concentration of 0.1% 10,11,14,18,19 . Positive response to tacrolimus monotherapy in a proportion of patients with NSV also agreed with the findings of previous RCTs whether the study population had similar age groups (i.e., older than 2 years old), 16 or included patients above 12 years old, 15 children 18 years or less, 10,11,19 or were restricted to adults 14,18 . On the other hand, the repigmentation rate was unsatisfactory in a previous RCT that used topical tacrolimus 0.1% in treatment of vitiligo 12 .…”
Section: Discussionsupporting
confidence: 91%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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