A Double-Blind Placebo-Controlled Trial of Fluoxetine for Repetitive Behaviors and Global Severity in Adult Autism Spectrum Disorders

Hollander, Eric; Soorya, Latha; Chaplin, William F.; Anagnostou, Evdokia; Taylor, Brian; Ferretti, Casara Jean; Wasserman, Stacey; Swanson, Erika N.; Settipani, Cara A.

doi:10.1176/appi.ajp.2011.10050764

Cited by 176 publications

(120 citation statements)

References 24 publications

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“…RCTs treating OCD symptoms among participants with ASD, 11 studies (Hollander et al 2005(Hollander et al , 2006aKing et al 2009;Martin et al 1999Martin et al , 2003McDougle et al 1997McDougle et al , 2000McDougle et al , 2005Posey et al 2007;Stigler et al 2009) evaluated interventions for children and adolescents (<18 years), 6 studies (McDougle et al 1995a(McDougle et al , 1996(McDougle et al , 1998Buchsbaum et al 2001;Hollander et al 2003Hollander et al , 2012 evaluated treatment for adults, and 2 studies (Gordon et al 1993;Potenza et al 1999) included both children and adults. None included participants with a formal diagnosis of OCD.…”

Section: Pharmacological Treatmentmentioning

confidence: 99%

Assessment and Treatment of Obsessions and Compulsions in Individuals with Autism Spectrum Disorders: a Systematic Review

Neil

Sturmey

2013

Rev J Autism Dev Disord

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The purpose of this paper is to systematically review empirical evidence for the assessment and treatment of obsessive-compulsive disorder (OCD) among individuals with autism spectrum disorders (ASD). Systematic searches were conducted in electronic databases, reference lists, and journals. Fifty-five studies met inclusion criteria: 21 studies investigating prevalence, symptom presentation, and assessment, as well as 34 intervention studies investigating 14 different interventions. Based on the Chambless criteria for treatment efficacy, four treatments (behavior analysis and behavior modification, risperidone, fluoxetine, and fluvoxamine for adults) met criteria for possible efficacious interventions for OCD among individuals with ASD. Positive intervention outcomes were reported in the majority of studies, but there was not enough research to make firm conclusions regarding efficacy of other treatments.

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Section: Pharmacological Treatmentmentioning

confidence: 99%

Assessment and Treatment of Obsessions and Compulsions in Individuals with Autism Spectrum Disorders: a Systematic Review

Neil

Sturmey

2013

Rev J Autism Dev Disord

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“…SSRIs block the re-uptake of serotonin at the synapse, thus increasing the availability of serotonin and the activation of serotonin receptors [15]. In children and adults, SSRIs have shown limited positive outcome, although all the studies have been with small sample sizes, with potential risk of bias [16,17]. In addition, SSRIs such as olanzapine, and fluvoxamine, have been shown to have undesirable side effects including irritability and weight gain [16,18].…”

Section: Review Articlementioning

confidence: 99%

Pharmacobiological Treatments in Autism Spectrum Disorders

Jayaraman¹,

Mundkur²

2017

IJCRR

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Autism spectrum disorders (ASD) refer to a group of neuro-developmental disorders affecting young children and adults. Currently, the treatment options for ASD are mostly restricted to treating its symptoms. Among the various approaches for treating ASD, pharmacobiology-based treatments are numerous. Our objective is to review the up-to-date information on different types of medications and briefly discuss the evidence-based potential of these treatments in ASD therapy. PubMed searches for reports and reviews on clinical data from the last 15 years, between 2002-2017, using search terms of each category of treatment along with the terms "autism", "mechanism", and/or "side effects" were conducted. Several pharmacobiological interventions have been prescribed for ASD, including antipsychotics, stimulants, antidepressants, supplements, and special diets. However, none of these methods is an effective ASD treatment, and only few show much promise. We provide a brief overview of the current pharmacobiological treatments for ASD, their mechanisms of action, and clinical research-based evidence on their effectiveness. Based on our review, we recommend that caution should be exercised when choosing a pharmacobiological treatment method for ASD as majority of existing evidence is not from large-scale long-term high quality studies.Future research should focus on rigorous investigative design, long-term implementation, and meaningful uniform outcome measurements.

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“…Nevertheless, they may again be characterized by specific neurobiological alterations, and they may constitute a particular treatment target. 13 One approach here may therefore be to have a specifier for SMD that acknowledges when it is secondary to a pervasive developmental disorder. Such a specifier would, on the one hand, emphasize that the SMD is not the primary diagnosis, but would, on the other hand, encourage clinicians to think about treatments that emerge from the general literature on SMD.…”

Section: ) What Is the Appropriate Diagnostic Hierarchy For Smd?mentioning

confidence: 99%

Stereotyped movement disorder in ICD-11

Stein

Woods

2014

Rev. Bras. Psiquiatr.

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According to current proposals for ICD-11, stereotyped movement disorder will be classified in the grouping of neurodevelopmental disorders, with a qualifier to indicate whether self-injury is present, similar to the classification of stereotypic movement disorder in DSM-5. At the same time, the WHO ICD-11 Working Group on the Classification of Obsessive-Compulsive and Related Disorders has proposed a grouping of body-focused repetitive behavior disorders within the obsessive-compulsive and related disorders (OCRD) cluster to include trichotillomania and skin-picking disorder. DSM-5 has taken a slightly different approach: trichotillomania and excoriation (skin picking) disorder are included in the OCRD grouping, while body-focused repetitive behavior disorder is listed under other specified forms of OCRD. DSM-5 also includes a separate category of nonsuicidal self-injury in the section on ''conditions for further study.'' There are a number of unresolved nosological questions regarding the relationships among stereotyped movement disorder, body-focused repetitive behavior disorders, and nonsuicidal self-injury. In this article, we attempt to provide preliminary answers to some of these questions as they relate to the ICD-11 classification of mental and behavioral disorders.

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A Double-Blind Placebo-Controlled Trial of Fluoxetine for Repetitive Behaviors and Global Severity in Adult Autism Spectrum Disorders

Cited by 176 publications

References 24 publications

Assessment and Treatment of Obsessions and Compulsions in Individuals with Autism Spectrum Disorders: a Systematic Review

Assessment and Treatment of Obsessions and Compulsions in Individuals with Autism Spectrum Disorders: a Systematic Review

Pharmacobiological Treatments in Autism Spectrum Disorders

Stereotyped movement disorder in ICD-11

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