Ethanolamine (EtN) is a core component of the glycosylphosphatidylinositol (GPI) moiety through which proteins can be attached to membranes. GPI assembly occurs in the endoplasmic reticulum by stepwise addition of the individual components from the respective donor molecules, with phosphatidylethanolamine (PE) providing the terminal EtN moiety. In addition, EtN has been identified as part of the ethanolaminephosphoglycerol (EPG) modification, which is attached to two glutamic acid residues in eukaryotic elong…
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