A disposable and sensitive non-enzymatic glucose sensor based on 3D graphene/Cu2O modified carbon paper electrode

Yang, Huisi; Bao, Jing; Qi, Yanli; Zhao, Jichun; Hu, Yian; Wu, Weixuan; Wu, Xicheng; Zhong, Daidi; Huo, Danqun; Hou, Changjun

doi:10.1016/j.aca.2020.08.010

Cited by 60 publications

(31 citation statements)

References 36 publications

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“…The mechanism of electrocatalytic oxidation of glucose on the Cu(II)/rGO modified electrode could be a multi-step precess due to the presence of Cu(0) metal, CuO, and Cu(OH)2 species in the nanocomplex. According to the previous reports 4, [41][42][43][44] , the commonly accepted mechanism of the glucose electrooxidation in the NaOH solution can be described as the following process. First, Cu is electrochemically oxidized to Cu(II) species in an alkaline medium, including CuO and Cu(OH)2 (equations ( 2)-( 3)).…”

Section: Resultsmentioning

confidence: 99%

An Electrochemically Reduced Copper/Reduced Graphene Oxide Film Modified Electrode for Sensitive Non-Enzymatic Glucose Detection in Human Serum

Phetsang

Kidkhunthod

Chanlek

et al. 2021

Preprint

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Numerous studies suggest that modification with functional nanomaterials can enhance the electrode electrocatalytic activity, sensitivity, and selectivity of the electrochemical sensors. Here, a highly sensitive and cost-effective disposable non-enzymatic glucose sensor based on copper(II)/reduced graphene oxide modified screen-printed carbon electrode is demonstrated. Facile fabrication of the developed sensing electrodes is carried out by the adsorption of copper(II) onto graphene oxide modified electrode, then following the electrochemical reduction. The proposed sensor illustrates good electrocatalytic activity toward glucose oxidation with a wide linear detection range from 0.10 mM to 12.5 mM, low detection limit of 65 µM, and high sensitivity of 172 µA mM− 1 cm− 2 along with satisfactory anti-interference ability, reproducibility, stability, and the acceptable recoveries for the detection of glucose in a human serum sample (95.6–106.4%). The copper(II)/reduced graphene oxide based sensor with the superior performances is a great potential for the quantitation of glucose in real samples.

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Section: Resultsmentioning

confidence: 99%

An Electrochemically Reduced Copper/Reduced Graphene Oxide Film Modified Electrode for Sensitive Non-Enzymatic Glucose Detection in Human Serum

Phetsang

Kidkhunthod

Chanlek

et al. 2021

Preprint

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“…However, the uniform dispersion of them onto graphene support, without increasing the electrode’s internal resistance and at the same time acquiring a high catalytic performance, remains a challenge. According to many research groups [ 22 , 31 , 42 , 61 , 62 , 63 , 64 , 65 , 66 ], an in-situ growth of the metallic nanoparticles inside graphene (or its derivatives) matrix, ensures homogeneous distribution of the nanoparticles and enrichment of the electron transport efficiency. Therefore, the formation of an inside nanostructured matrix with graphene (metal-graphene matrix composites), enhances significantly the electrocatalytic activity towards GER.…”

Section: Graphene-based Nanomaterials For Glucose Electrochemical Sensorsmentioning

confidence: 99%

“…In the context of exploring the potentials of MOF-derived graphene-based nanomaterials as electrodes for electrochemical sensors, some groups employed stabilizers (e.g., poly(vinylpyrrolidone), in order to achieve uniform stabilization of the metal nanoparticles into graphene network. The intrusion of such stabilizers forms a very good interface, boosting the as-developed sensor’s sensitivity [ 42 ]. When 2D MOF ultrathin sheets are in-situ fabricated with graphene and metal nanoparticles; mass and electron transfer are higher, and so glucose electrooxidation reaction is further promoted.…”

Section: Graphene-based Nanomaterials For Glucose Electrochemical Sensorsmentioning

confidence: 99%

“…According to the multi-step GER mechanism (Equation (20)), Cu is initially oxidized to CuO and Cu(OH) 2 (Cu(II) species), which in their turn are oxidized to Cu(III) (CuOOH and Cu(OH) 4− ). The latter catalyses the adsorbed glucose molecules to gluconolactone and then to gluconic acid, while Cu(III) is reduced back to Cu(II).The GER mechanism in alkaline media (e.g., 0.1 M NaOH), over CuO/Cu 2 O-based electrocatalysts proceeds in a similar way [ 42 ]:

…”

Section: Introductionmentioning

confidence: 99%

“…Thus, the key-requirement is this route to be of low internal resistance and at the same time to offer the capacity for as many as possible active sites. Graphene and especially reduced graphene oxide are considered [ 42 , 44 , 45 , 46 , 47 ] of the most appropriate materials to use as support since they facilitate the required electron transfer among the reaction sites so that the redox pair M(II)/M(III) or M(III)/M(IV) to be created continuously for promoting GER. Their superior electric conductivity, large surface area, as well as their biocompatibility facilitate GER.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Cost Effective Synthesis of Graphene Nanomaterials for Non-Enzymatic Electrochemical Sensors for Glucose: A Comprehensive Review

Balkourani

Damartzis

Brouzgou

et al. 2022

Sensors

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The high conductivity of graphene material (or its derivatives) and its very large surface area enhance the direct electron transfer, improving non-enzymatic electrochemical sensors sensitivity and its other characteristics. The offered large pores facilitate analyte transport enabling glucose detection even at very low concentration values. In the current review paper we classified the enzymeless graphene-based glucose electrocatalysts’ synthesis methods that have been followed into the last few years into four main categories: (i) direct growth of graphene (or oxides) on metallic substrates, (ii) in-situ growth of metallic nanoparticles into graphene (or oxides) matrix, (iii) laser-induced graphene electrodes and (iv) polymer functionalized graphene (or oxides) electrodes. The increment of the specific surface area and the high degree reduction of the electrode internal resistance were recognized as their common targets. Analyzing glucose electrooxidation mechanism over Cu- Co- and Ni-(oxide)/graphene (or derivative) electrocatalysts, we deduced that glucose electrochemical sensing properties, such as sensitivity, detection limit and linear detection limit, totally depend on the route of the mass and charge transport between metal(II)/metal(III); and so both (specific area and internal resistance) should have the optimum values.

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Flexible Electrode for Rapid Glucose Detection Based on CuO Nanoflowers/Stereo‐Graphene Coated on Carbon Cloth

et al. 2022

Self Cite

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Designing a highly sensitive, fast response, cheap, and flexible biosensing platform has important significance in the diagnosis of diabetes. Herein, we developed an ultra‐fast and sensitive glucose sensor based on CuO nanoflowers‐coated stereo‐graphene electrode on carbon cloth. The three‐dimensional graphene (3DG) nanostructures were established on the carbon cloth (CC) by radio frequency plasma enhanced chemical vapor deposition (RF‐PECVD), and CuO nanoflowers subsequently obtained via chemical deposition. The prepared CuO@3DG@CC electrode with self‐assembled structures provided abundant ion diffusion channels, large specific surface area and high conductivity, which shows an ultrasensitive current response to glucose. The detection limit of the sensor is as low as 0.068 μM and the response efficiency is as fast as 0.5 s. The electrode has two linear ranges with 0.5–115.5 μM and 165.5–1165.5 μM and has a strong anti‐interference ability and shows an excellent stability. This kind of flexible enzyme‐free glucose sensor has been successfully applied to the detection of glucose in actual serum samples and shows a good accuracy, which is likely be applied to the medical testing field and the commercial production and has potential to further applied in wearable sensors.

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A disposable and sensitive non-enzymatic glucose sensor based on 3D graphene/Cu2O modified carbon paper electrode

Cited by 60 publications

References 36 publications

An Electrochemically Reduced Copper/Reduced Graphene Oxide Film Modified Electrode for Sensitive Non-Enzymatic Glucose Detection in Human Serum

An Electrochemically Reduced Copper/Reduced Graphene Oxide Film Modified Electrode for Sensitive Non-Enzymatic Glucose Detection in Human Serum

Cost Effective Synthesis of Graphene Nanomaterials for Non-Enzymatic Electrochemical Sensors for Glucose: A Comprehensive Review

Flexible Electrode for Rapid Glucose Detection Based on CuO Nanoflowers/Stereo‐Graphene Coated on Carbon Cloth

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