A disposable acoustofluidic chip for nano/microparticle separation using unidirectional acoustic transducers

Zhao, Shuaiguo; Wu, Mengxi; Yang, Shujie; Wu, Yuqi; Gu, Yuyang; Chen, Chuyi; Ye, Jennifer; Xie, Zhemiao; Tian, Zhenhua; Bachman, Hunter; Huang, Po‐Hsun; Xia, Jianping; Zhang, Peiran; Zhang, Heying; Huang, Tony Jun

doi:10.1039/d0lc00106f

Cited by 86 publications

(64 citation statements)

References 69 publications

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“…Despite valuable provided insight of 2D simulations in acoustofluidic problems, the developed 3D model can overcome their limitations in capturing the impression of established SSAW and taSSAW field non-uniformities along the channel length on the particle trajectory, and final inter-particle distance at channel outlet under highly interactive involved parameters. The presented 3D model would have sufficient capability and versatility to be adopted to simulate novel complex on-chip configuration like taSSAW microfluidic devices 21 and disposable acoustofluidic chips 44 . Furthermore, it helps to make a more accurate prior approximation for 2D simplification of the favorable device, which might not always be straightforward.…”

Section: Resultsmentioning

confidence: 99%

3D Numerical Simulation of Acoustophoretic Motioninduced by Boundary-driven Acoustic Streaming Instanding Surface Acoustic wave Microfluidics

Namnabat

Zand

Houshfar

2021

Preprint

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Standing surface acoustic waves (SSAWs) have been widely utilized in microfluidic devices to manipulate various cells and micro/nano-objects. Despite widespread application, a time-/cost-efficient versatile 3D model that predicts the particle behavior in such platforms is still lacking. Herein, a fully-coupled 3D numerical simulation of boundary-driven acoustic streaming in the acoustofluidic devices utilizing SSAWs has been conducted based on the limiting velocity finite element method. Through this efficient computational method, the underlying physical interplay from the electromechanical fields of the piezoelectric substrate to different acoustofluidic effects (acoustic radiation force and streaming-induced drag force), fluid-solid interactions, the 3D influence of novel on-chip configuration like tilted-angle SSAW (taSSAW) based devices, required boundary conditions, meshing technique, and demanding computational cost, are discussed. As an experimental validation, a taSSAW platform fabricated on YX 128 LiNbO3 substrate for separating polystyrene beads is simulated, which demonstrates acceptable agreement with reported experimental observations. Subsequently, as an application of the presented 3D model, a novel sheathless taSSAW cell/particle separator is conceptualized and designed. The presented 3D fully-coupled model, due to the more time-/cost-efficient performance than precedented 3D models, the capability to model complex on-chip configurations, and overcome shortcomings and limitations of 2D simulations could be considered as a powerful tool in further the designing and optimizing SSAW microfluidics.

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Section: Resultsmentioning

confidence: 99%

3D Numerical Simulation of Acoustophoretic Motioninduced by Boundary-driven Acoustic Streaming Instanding Surface Acoustic wave Microfluidics

Namnabat

Zand

Houshfar

2021

Preprint

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“…Comparing with the SSAW, the TaSSAW has the ability to separate the particles with a larger distance, enabling highly efficient and sensitive separation. Using TaSSAWs, Zhao et al demonstrated a disposable device that can separate particles with a wide range from 200 nm to 10 µm [ 80 ]. Instead of changing the geometry of the IDT, Rambach et al introduced a simple and flexible separation technique for different-sized particles which enables shaping of the SSAW by shifting the PDMS foil’s geometry [ 81 ].…”

Section: Saw-based Separationmentioning

confidence: 99%

Acoustic Microfluidic Separation Techniques and Bioapplications: A Review

Gao

Lin

et al. 2020

Micromachines

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Microfluidic separation technology has garnered significant attention over the past decade where particles are being separated at a micro/nanoscale in a rapid, low-cost, and simple manner. Amongst a myriad of separation technologies that have emerged thus far, acoustic microfluidic separation techniques are extremely apt to applications involving biological samples attributed to various advantages, including high controllability, biocompatibility, and non-invasive, label-free features. With that being said, downsides such as low throughput and dependence on external equipment still impede successful commercialization from laboratory-based prototypes. Here, we present a comprehensive review of recent advances in acoustic microfluidic separation techniques, along with exemplary applications. Specifically, an inclusive overview of fundamental theory and background is presented, then two sets of mechanisms underlying acoustic separation, bulk acoustic wave and surface acoustic wave, are introduced and discussed. Upon these summaries, we present a variety of applications based on acoustic separation. The primary focus is given to those associated with biological samples such as blood cells, cancer cells, proteins, bacteria, viruses, and DNA/RNA. Finally, we highlight the benefits and challenges behind burgeoning developments in the field and discuss the future perspectives and an outlook towards robust, integrated, and commercialized devices based on acoustic microfluidic separation.

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“…As previously discussed in the cell sorting section, SAW is a technique often utilized in BioMEMS devices. Zhao et al described a disposable PDMS acoustofluidic chip for nano/microparticle separation [28]. The authors demonstrated the use of a hybrid channel design with hard and soft materials and tilted-angle standing SAWs.…”

Section: Laser Cutting Plasma-activated Bondingmentioning

confidence: 99%

Latest Updates on the Advancement of Polymer-Based Biomicroelectromechanical Systems for Animal Cell Studies

Garcia-Ramirez

Cerda-Kipper

Alvarez

et al. 2021

Advances in Polymer Technology

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Biological sciences have reached the fundamental unit of life: the cell. Ever-growing field of Biological Microelectromechanical Systems (BioMEMSs) is providing new frontiers in both fundamental cell research and various practical applications in cell-related studies. Among various functions of BioMEMS devices, some of the most fundamental processes that can be carried out in such platforms include cell sorting, cell separation, cell isolation or trapping, cell pairing, cell-cell communication, cell differentiation, cell identification, and cell culture. In this article, we review each mentioned application in great details highlighting the latest advancements in fabrication strategy, mechanism of operation, and application of these tools. Moreover, the review article covers the shortcomings of each specific application which can open windows of opportunity for improvement of these devices.

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A disposable acoustofluidic chip for nano/microparticle separation using unidirectional acoustic transducers

Abstract: A disposable acoustofluidic platform was developed for nano/microparticle separation with high versatility, precision, and biocompatibility.

Cited by 86 publications

References 69 publications

3D Numerical Simulation of Acoustophoretic Motioninduced by Boundary-driven Acoustic Streaming Instanding Surface Acoustic wave Microfluidics

3D Numerical Simulation of Acoustophoretic Motioninduced by Boundary-driven Acoustic Streaming Instanding Surface Acoustic wave Microfluidics

Acoustic Microfluidic Separation Techniques and Bioapplications: A Review

Latest Updates on the Advancement of Polymer-Based Biomicroelectromechanical Systems for Animal Cell Studies

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