A disadvantageous effect of adsorption of barium by melanin on transforming activity

Omata, Yasuhiro; Yoshinaga, Masafumi; Yajima, Ichiro; Ohgami, Nobutaka; Hashimoto, Kazunori; Higashimura, Kaho; Kato, Masaya

doi:10.1016/j.chemosphere.2018.07.022

Cited by 8 publications

(11 citation statements)

References 22 publications

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“…Thus, we newly demonstrated a cheap and highefficacy remediation system that is useful for removal of toxic elements in well drinking water. We also demonstrated that melanin could bind barium and other elements in mice, cultured cells, and cell-free systems [27,28]. Since synthesized melanin is expensive, its practical realization may be difficult as a novel remediation system for elements in drinking water.…”

Section: Remediation For Bariummentioning

confidence: 92%

“…On the other hand, experimental studies using animals (in vivo) and cultured cells (in vitro) could be effective approaches for evaluating the pathogenic risks for environmental factors-originating diseases with elucidation of their mechanisms. Model animals for diseases might be useful for estimating the lesions caused by environmental factors and developing the preventive methods [23][24][25][26][27][28][29][30][31][32][33]. Cell physiological and biochemical examinations are also useful for health risk assessment in vitro [27][28][29][30][34][35][36][37][38][39][40][41].…”

Section: Introductionmentioning

confidence: 99%

“…Model animals for diseases might be useful for estimating the lesions caused by environmental factors and developing the preventive methods [23][24][25][26][27][28][29][30][31][32][33]. Cell physiological and biochemical examinations are also useful for health risk assessment in vitro [27][28][29][30][34][35][36][37][38][39][40][41]. Expression and activity levels of proto-oncogene and oncogene products (protein tyrosine kinases) such as c-SRC, c-RET, and oncogenic RET have been shown to be correlated with malignant transformation from nontumorigenic cells to tumorigenic cells and with progression to further acquirement of malignant characteristics in transformed cells (carcinoma cells) [6,[37][38][39][40][41][42][43][44][45][46][47].…”

Section: Introductionmentioning

confidence: 99%

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Multidisciplinary approach to assess the toxicities of arsenic and barium in drinking water

Kato

Ohgami

Ohnuma³

et al. 2020

Environ Health Prev Med

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Well water could be a stable source of drinking water. Recently, the use of well water as drinking water has been encouraged in developing countries. However, many kinds of disorders caused by toxic elements in well drinking water have been reported. It is our urgent task to resolve the global issue of element-originating diseases. In this review article, our multidisciplinary approaches focusing on oncogenic toxicities and disturbances of sensory organs (skin and ear) induced by arsenic and barium are introduced. First, our environmental monitoring in developing countries in Asia showed elevated concentrations of arsenic and barium in well drinking water. Then our experimental studies in mice and our epidemiological studies in humans showed arsenic-mediated increased risks of hyperpigmented skin and hearing loss with partial elucidation of their mechanisms. Our experimental studies using cultured cells with focus on the expression and activity levels of intracellular signal transduction molecules such as c-SRC, c-RET, and oncogenic RET showed risks for malignant transformation and/or progression arose from arsenic and barium. Finally, our original hydrotalcite-like compound was proposed as a novel remediation system to effectively remove arsenic and barium from well drinking water. Hopefully, comprehensive studies consisting of (1) environmental monitoring, (2) health risk assessments, and (3) remediation will be expanded in the field of environmental health to prevent various disorders caused by environmental factors including toxic elements in drinking water.

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Section: Remediation For Bariummentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Multidisciplinary approach to assess the toxicities of arsenic and barium in drinking water

Kato

Ohgami

Ohnuma³

et al. 2020

Environ Health Prev Med

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“…Previous studies have shown the protective effects of melanin in the skin against ultraviolet light irradiation [3, 4]. Previous studies have also shown adsorption of toxic elements such as mercury, lead [5], cadmium [6], and barium [7] by melanin. However, there is a lack of evidence for interactions of melanin with various toxic elements strictly based on chemical theory.…”

Section: Introductionmentioning

confidence: 99%

“…We previously established constitutively activated RET, a receptor-type tyrosine kinase [8–10], hairless transgenic mice (HL-RET-mice) of lines 242 and 304, which have different levels of skin pigmentation [7]. We objectively evaluated the skin pigmentations levels for HL-RET-mice of lines 242 and 304 and wild-type hairless mice as L * values by using a reflectance spectrophotometer [7, 11]. Moreover, we newly showed the interaction of melanin with barium after showing that the level of barium increased with increases in the levels of pigmentation in the skin in the HL-RET-mice of lines 242 and 304 and wild-type hairless mice [7].…”

Section: Introductionmentioning

confidence: 99%

Adsorption of molybdenum by melanin

Chen

Hashimoto

Omata

et al. 2019

Environ Health Prev Med

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Background Melanin is detectable in various sense organs including the skin in animals. It has been reported that melanin adsorbs toxic elements such as mercury, cadmium, and lead. In this study, we investigated the adsorption of molybdenum, which is widely recognized as a toxic element, by melanin. Methods Molybdenum level of the mouse skin was measured by inductively coupled plasma mass spectrometry. The pigmentation level of murine skin was digitalized as the L * value by using a reflectance spectrophotometer. An in vitro adsorption assay was performed to confirm the interaction between molybdenum and melanin. Results Our analysis of hairless mice with different levels of skin pigmentation showed that the level of molybdenum increased with an increase in the level of skin pigmentation ( L * value). Moreover, our analysis by Spearman’s correlation coefficient test showed a strong correlation ( r = − 0.9441, p < 0.0001) between L * value and molybdenum level. Our cell-free experiment using the Langmuir isotherm provided evidence for the adsorption of molybdenum by melanin. The maximum adsorption capacity of 1 mg of synthetic melanin for molybdenum was 131 μg in theory. Conclusion Our in vivo and in vitro results showed a new aspect of melanin as an adsorbent of molybdenum. Electronic supplementary material The online version of this article (10.1186/s12199-019-0791-y) contains supplementary material, which is available to authorized users.

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Bioaccessibility by perspiration uptake of minerals from two different sulfurous peloids

Bastos

Rocha

Patinha

et al. 2023

Environ Geochem Health

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The risks associated with the use of peloids in thermal centers, spas, or at home, must be tested to develop appropriate safety guidelines for peloids formulations and the release of substances of high concern. Additionally, the beneficial effects of some elements on human health should be assessed to aid in interpreting the therapeutic action and effectiveness of pelotherapy on dermatological or osteomuscular disorders. Therefore, a methodology was developed to better understand the biogeochemical behavior of the elements in formulated peloids. Two peloids were formulated with the same clay and two different sulfurous mineral-medicinal waters for 90 days, with light stirring every 15 days. Bentonite clay, with a high content of smectite and Ca and Mg as the main exchangeable cations, and high heat capacity, was used. The selected mineral-medicinal waters were collected from two Portuguese thermal centers with recognized therapeutic efficacy for rheumatic, respiratory and dermatological pathologies. The peloids were used without drying and withdrawn directly from the maturation tank, and a mixture of bentonite and demineralized water was prepared as a reference sample. A stabilized, ready-to-use, artificial perspiration test was used to simulate the peloids’ interaction with skin. Thirty-one elements extracted from the two prepared peloids were analyzed using ICP-MS. The data were analyzed and related to the mineralogical composition of the original clay and supernatant composition of the maturation tanks. The content of some potentially toxic elements and metals’ bioaccessibility by perspiration showed very low solubility and undetectable amounts extracted from the studied samples. This analytical method provided reliable information on dermal exposure and the identification of some elements that may enter the systemic circulation, requiring implementation of surveillance and control measures. Graphical abstract

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A disadvantageous effect of adsorption of barium by melanin on transforming activity

Cited by 8 publications

References 22 publications

Multidisciplinary approach to assess the toxicities of arsenic and barium in drinking water

Multidisciplinary approach to assess the toxicities of arsenic and barium in drinking water

Adsorption of molybdenum by melanin

Bioaccessibility by perspiration uptake of minerals from two different sulfurous peloids

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