A dinuclear zinc(II) complex of a new unsymmetric ligand with an N5O2 donor set; A structural and functional model for the active site of zinc phosphoesterases

Synthesis, structure and magnetic characterization of dinuclear copper(ii) complexes bridged by bicompartmental phenolate

“…1,2,[4][5][6][10][11][12][13] This property made this class of compounds to serve as good candidates to mimic biological systems and as a consequence they have been extensively employed to elucidate the structural spectroscopic parameters and to mimic the mechanism of metalloenzymes in catecholase oxidases, Mn catalases, metallo-b-lactamases (MbL) 7,13,[26][27][28][29][30] and particularly in the hydrolytic systems. 8,21,31,32 These includes phosphodiester bonds of biomolecules such as DNA, purple acid phosphatases and Zn phosphesterases. 8,21,[31][32][33] In addition to the advantages of the compartmental dinuclear metal(II) complexes which derived from phenolic compounds in enhancing our understanding for the role of metal ions in the active sides of metalloenzymes, the compounds could provide interesting magnetic properties as a result of the magnetic coupling between the two paramagnetic metal centers (3d [7][8][9] ) bridged via the phenoxido group.…”

Synthesis, structure and magnetic characterization of dinuclear copper(II) complexes of 2,6-bis[bis(pyridine-2-ylmethyl)aminomethyl]-4-methylphenol

“…In addition the complexes reveal efficient catalytic activity, particularly in hydrolytic reactions that involve hydrolysis of phosphodiester, DNA cleavage and carbonic hydratase and therefore, have been used to elucidate the reaction mechanism of some metalloenzymes [1][2][3][4][5][6][7][8]. This is due to the key role played by the phenolic group in such compounds such as (i) charge neutralization, (ii) bridging capability via the phenolic group, and (iii) great synthetic flexibility associated with the benzene ring [9].…”

Phosphate Diester Cleavage, DNA Interaction and Cytotoxic Activity of a Bimetallic Bis(1,4,7‐triazacyclononane) Zinc Complex

“…This mechanism is not unprecedented for dizinc complexes. [36,37] (M = Zn, Cu, Mn, Fe) that have been extensively studied by Neves, Schenk and co-workers proceeds via a mechanism that involves monodentate coordination to the divalent metal ion followed by intramolecular attack of a terminally Fe III -bound hydroxide. [39][40][41][42] It was concluded that the μ-OH was a poorer nucleophile than the terminal OH.…”