A designed equine herpes thymidine kinase (EHV4 TK) variant improves ganciclovir-induced cell-killing

McSorley, Theresa; Ort, Stephan; Monnerjahn, Christian; Konrad, Manfred

doi:10.1016/j.bcp.2013.11.011

Cited by 2 publications

(2 citation statements)

References 32 publications

(46 reference statements)

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“…After 2-3 days, the stable colonies were monitored using a fluorescence-microscope and further sub-cultured. The established stable cell lines were maintained in complete DMEM medium containing 300 µg/ml of G418 [85].…”

Section: Cell-culture and Stable Hek293 Cell Linementioning

confidence: 99%

“…We decided to use HEK293 cells as a model system as previously described for ganciclovirinduced cell killing [111], and tested hGMPK in order to explore whether it would sensitize HEK293 cells in the presence of the medically most relevant prodrug 6-thioguanine. This question was important because if wild-type hGMPK increases the sensitivity of cells towards 6-TG, then the next step would be testing an engineered enzyme to further reduce high doses of the drug required for cell killing.…”

Section: Enhanced Cytotoxicity Of the Antileukemic Drug 6-thioguanine...mentioning

confidence: 99%

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Biochemical Characterization of Human Guanylate Kinase and Mitochondrial Thymidine Kinase: Essential Enzymes for the Metabolic Activation of Nucleoside Analog Prodrugs

Khan¹

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I would like to express my deepest gratitude to Dr. Manfred Konrad for offering me the opportunity to do my Ph.D. research work in the Enzyme Biochemistry Research Group. It was indeed an honor and great experience to work under his supervision, and in the very dynamic scientific environment of MPI-bpc, Goettingen. I am highly grateful for his guidance and great support in starting several collaborative projects. I am highly thankful to him for reviewing my PhD thesis, and for his very constructive critique and useful comments.My profound gratitude to the Ph.D. thesis committee members, Prof. Dr. Kai Tittmann and

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Section: Cell-culture and Stable Hek293 Cell Linementioning

confidence: 99%

Section: Enhanced Cytotoxicity Of the Antileukemic Drug 6-thioguanine...mentioning

confidence: 99%

Biochemical Characterization of Human Guanylate Kinase and Mitochondrial Thymidine Kinase: Essential Enzymes for the Metabolic Activation of Nucleoside Analog Prodrugs

Khan¹

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Oncolytic viral therapy for gliomas: Advances in the mechanisms and approaches to delivery

Romanishin,

Vasilev,

Khasanshin

et al. 2024

Virology

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A designed equine herpes thymidine kinase (EHV4 TK) variant improves ganciclovir-induced cell-killing

Cited by 2 publications

References 32 publications

Biochemical Characterization of Human Guanylate Kinase and Mitochondrial Thymidine Kinase: Essential Enzymes for the Metabolic Activation of Nucleoside Analog Prodrugs

Biochemical Characterization of Human Guanylate Kinase and Mitochondrial Thymidine Kinase: Essential Enzymes for the Metabolic Activation of Nucleoside Analog Prodrugs

Oncolytic viral therapy for gliomas: Advances in the mechanisms and approaches to delivery

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