A derivatization-directed three-component synthesis of fluorescent spiro [dihydropyridine-4,3ʹ-indoline]s

Najafizadeh, Faranak; Rad‐Moghadam, Kurosh; Kalurazi, Soraya Yaghoubi

doi:10.1177/1747519820909374

Cited by 6 publications

(1 citation statement)

References 32 publications

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“…Recently, Rad-Moghadam and coworkers obtained the spiro 1,4-dihydropyrido [3,2- c ]coumarin derivatives 156a – f via a three-component reaction of 4-aminocoumarin ( 13 ), isatin derivatives 154a – f and 3-methyl-1 H -pyrazol-5-amine ( 155 ) in the presence of p -TSA in ethanol under sonication or heating [ 120 ]. They proposed two possible pathways ( Scheme 35 ).…”

Section: Synthetic Strategies For the Preparation Of Fused Pyridocoum...mentioning

confidence: 99%

An Overview on the Synthesis of Fused Pyridocoumarins with Biological Interest

Douka¹,

Litinas²

2022

Molecules

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Pyridocoumarins are a class of synthetic and naturally occurring organic compounds with interesting biological activities. This review focuses on the synthetic strategies for the synthesis of pyridocoumarins and presents the biological properties of those compounds. The synthesis involves the formation of the pyridine ring, at first, from a coumarin derivative, such as aminocoumarins, hydroxycoumarins, or other coumarins. The formation of a pyranone moiety follows from an existing pyridine or piperidine or phenol derivative. For the above syntheses, [4 + 2] cycloaddition reactions, multi-component reactions (MCR), as well as metal-catalyzed reactions, are useful. Pyridocoumarins present anti-cancer, anti-HIV, antimalarial, analgesic, antidiabetic, antibacterial, antifungal, anti-inflammatory, and antioxidant activities.

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Section: Synthetic Strategies For the Preparation Of Fused Pyridocoum...mentioning

confidence: 99%

An Overview on the Synthesis of Fused Pyridocoumarins with Biological Interest

Douka¹,

Litinas²

2022

Molecules

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Tailor‐Made Pyrazolopyridines and Fused Pyrazolopyridines: Recent Updates toward Sustainable Synthesis

Alam Mondal,

Ghosh

2024

ChemistrySelect

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Over the last three decades, owing to labour cost, time and especially environmental issues, one‐pot synthesis of heterocyclic compounds involving tandem or multicomponent (sequential or consecutive) reactions has gained particular attention worldwide. Most of the marketed drug molecules hold one or more heterocyclic rings. Due to some side effects of several drugs along with the gradual emergence of antimicrobial resistance, the necessity for developing new heterocyclic molecules continues; special attention should be paid in this respect towards employing more one‐pot reactions for their syntheses. Pyrazolopyridines are fused heterocycles holding pyridine and pyrazole and possess a wide variety of biological and pharmaceutical properties. Several existing drug molecules also bear pyrazolopyridine scaffolds. The present perspective is an endeavour to encompass green syntheses of different isomeric pyrazolopyridine systems, most of these published during the past five years or more for a few cases.

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