A Customizable Multi-channel Stimulator for Cortical Neuroprosthesis

Ferrández, José Manuel; Liano, E.; Bonomini, P.; Martínez, José Javier Pérez-Fadón; Toledo, J.; Fernández, Eduardo

doi:10.1109/iembs.2007.4353390

Cited by 11 publications

(11 citation statements)

References 5 publications

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“…An advantage of the epiretinal implant is that its surgical approach in the vitreous cavity is well understood and routine. 48 Also, epiretinal implantation allows for the vitreous to act as a heat sink for the implant. Subretinal prosthesis, on the contrary, poses the risk of thermal injury to neurons due to their close proximity.…”

Section: Retinal Bionic Eyementioning

confidence: 99%

“…Also, the receptive field properties of the retina are well known and the perception of light produced by electrical stimulation of an area of the retina is predictable. 48 Retinal bionic eyes are classified into two types based on their target location: epiretinal and subretinal. The epiretinal bionic eyes stimulate the cells of the inner retina.…”

Section: Retinal Bionic Eyementioning

confidence: 99%

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Novel vision restoration techniques: 3D bioprinting, gene and stem cell therapy, optogenetics, and the bionic eye

Menon

Vijayavenkataraman

2022

Artificial Organs

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Sight is one of our most dominant senses, the loss of which can often lead to socioeconomic distress and a major deterioration in the quality of life for the affected individual. The field of ophthalmology has come a long way because of its inception with major breakthroughs in the development of contact lenses, cataract surgeries, and LASIK vision correction surgeries. Despite these developments, it is estimated that there are 253 million visually impaired people in the world of which 39 million were considered legally blind. 1 Data confirms that 80% of this 39 million were older than the age of 50. [2][3][4] This overwhelming percentage is indicative of a high number of patients with progressive blinding disorders like age-related macular disorder (AMD), retinitis Pigmentosa (RP), and diabetic retinopathy. There are very few clinically approved treatments for diseases that cause

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Section: Retinal Bionic Eyementioning

confidence: 99%

Section: Retinal Bionic Eyementioning

confidence: 99%

Novel vision restoration techniques: 3D bioprinting, gene and stem cell therapy, optogenetics, and the bionic eye

Menon

Vijayavenkataraman

2022

Artificial Organs

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“…Additionally, some cortical implants like the Utah Electrode Array and the customized multi-channel stimulator for a cortical visual neuroprosthesis can be used for blinds (Ferrandez et al, 2007 ). Such stimulators have been proven to inject current (charge) in a safe and precise way in an acute animal experimentation.…”

Section: Biocompatibility and Neural Recording/stimulationmentioning

confidence: 99%

Selectivity and Longevity of Peripheral-Nerve and Machine Interfaces: A Review

2017

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For those individuals with upper-extremity amputation, a daily normal living activity is no longer possible or it requires additional effort and time. With the aim of restoring their sensory and motor functions, theoretical and technological investigations have been carried out in the field of neuroprosthetic systems. For transmission of sensory feedback, several interfacing modalities including indirect (non-invasive), direct-to-peripheral-nerve (invasive), and cortical stimulation have been applied. Peripheral nerve interfaces demonstrate an edge over the cortical interfaces due to the sensitivity in attaining cortical brain signals. The peripheral nerve interfaces are highly dependent on interface designs and are required to be biocompatible with the nerves to achieve prolonged stability and longevity. Another criterion is the selection of nerves that allows minimal invasiveness and damages as well as high selectivity for a large number of nerve fascicles. In this paper, we review the nerve-machine interface modalities noted above with more focus on peripheral nerve interfaces, which are responsible for provision of sensory feedback. The invasive interfaces for recording and stimulation of electro-neurographic signals include intra-fascicular, regenerative-type interfaces that provide multiple contact channels to a group of axons inside the nerve and the extra-neural-cuff-type interfaces that enable interaction with many axons around the periphery of the nerve. Section Current Prosthetic Technology summarizes the advancements made to date in the field of neuroprosthetics toward the achievement of a bidirectional nerve-machine interface with more focus on sensory feedback. In the Discussion section, the authors propose a hybrid interface technique for achieving better selectivity and long-term stability using the available nerve interfacing techniques.

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“…Furthermore, electrodes separated by at least 0.5 mm were able to elicit independent phosphenes. Currently, multidisciplinary efforts to develop a reliable visual cortex implants have been recently proposed [103][104][105] (see [106] for a review). Yet, several scientific and technological challenges must be overcome before the implementation of fully functional visual cortex prostheses.…”

Section: Visual Neuroprosthesesmentioning

confidence: 99%

Central nervous system microstimulation: Towards selective micro-neuromodulation

Urdaneta

Koivuniemi

Otto

2017

Current Opinion in Biomedical Engineering

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Highlights: • Electrical microstimulation to modulate neural activity has emerged as a critical tool in brain research, neurotherapeutics, and bidirectional neuroprostheses. • Recent successes in sensory, motor, auditory, visual, and cognitive neuroprostheses demonstrate a need for more focal micro-neuromodulation technologies. • Advances in electronics, optics, and magnetics are leading towards stable, high spatialresolution interfaces. • Advances in neuroprosthetic technologies may one day enable single neuron, whole-brain micro-neuromodulation.

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A Customizable Multi-channel Stimulator for Cortical Neuroprosthesis

Cited by 11 publications

References 5 publications

Novel vision restoration techniques: 3D bioprinting, gene and stem cell therapy, optogenetics, and the bionic eye

Novel vision restoration techniques: 3D bioprinting, gene and stem cell therapy, optogenetics, and the bionic eye

Selectivity and Longevity of Peripheral-Nerve and Machine Interfaces: A Review

Central nervous system microstimulation: Towards selective micro-neuromodulation

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