A cross-sectional study ofMycoplasma genitaliuminfection and correlates in women undergoing population-based screening or clinic-based testing forChlamydiainfection in London

Abstract

ObjectiveTo determine Mycoplasma genitalium infection and correlates among young women undergoing population-based screening or clinic-based testing for Chlamydia infection.DesignCross-sectional study.SettingNational Chlamydia Screening Programme (NCSP) and two London sexually transmitted infection (STI) clinics.Participants2441 women aged 15–64 years who participated in the NCSP and 2172 women who attended two London STI clinics over a 4-month period in 2009.Outcome measures(1) M genitalium prevalence in defined populations (%). (2) Age-adjusted ORs (aORs) for correlates of M genitalium infection.ResultsThe overall frequency of M genitalium and Chlamydia trachomatis was 3% and 5.4%, respectively. Co-infection was relatively uncommon (0.5% of all women); however 9% of women with C trachomatis also had M genitalium infection. M genitalium was more frequently detected in swab than urine samples (3.9 vs 1.3%, p<0.001) with a significantly higher mean bacterial load (p ≤ 0.001). Among NCSP participants, M genitalium was significantly more likely to be diagnosed in women of black/black British ethnicity (aOR 2.3, 95% CI 1.2 to 4.5, p=0.01). M genitalium and C trachomatis and were both significantly associated with multiple sexual partners in the past year (aOR 2.4, 95% CI 1.3 to 4.4, p=0.01 and aOR 2.0, 95% CI 1.4 to 2.8, p<0.01). Among STI clinic attendees, M genitalium was more common in women who were less than 25 years in age.ConclusionsM genitalium is a relatively common infection among young women in London. It is significantly more likely to be detected in vulvovaginal swabs than in urine samples. Co-infection with Chlamydia is uncommon. The clinical effectiveness of testing and treatment strategies for M genitalium needs further investigation.

The prevalence of, and risk factors for, mycoplasma genitalium infection among infertile women in Ibadan: A cross-sectional study

“…The risk factors that are confirmed to be associated with M. genitalium infection from this study included: family type (single and serial monogamy) and multiple sexual partners in which the respondents have more than one lifetime sex partners and/or have husbands who equally have other sexual partners thus corroborating the findings of previous studies (4,(24)(25)(26)(27)(28). Thurman and his co-workers reported that M. genitalium was detected in 9.5% and 10.6% of women and men in heterosexual relationships reporting to an STI clinic (27).…”

Epidemiology ofMycoplasma genitaliumin British men and women aged 16–44 years: evidence from the third National Survey of Sexual Attitudes and Lifestyles (Natsal-3)

“… 9 London Chlamydia Screening Programme 15–24 1017 Cervical/ vaginal swab 4.1% (3.0–5.5) See above Svenstrup et al. 9 Denmark Chlamydia Screening Programme 21–23 921 Vulvo-vaginal swab 2.3% (1.3–3.2) > 10 lifetime partners, ≥ 2 partners in the past year, shorter duration of steady relationship, partner with symptoms Andersen et al. 6 Australia General practice 15–25 1116 Vulvo-vaginal swab 1.6% (0.7–2.6) Indigenous status, ≥ 2 partners in the past year, ≥ 3 partners in the past year without condoms Walker et al.…”

ADN de Chlamydia trachomatis en leucocitos de sangre periférica de neonatos

“…Además, la co-infección entre C. trachomatis y especies de Mycoplasma o Ureaplasma ha sido reportada en pacientes con VIH 33 y en mujeres de 15 a 64 años de edad, que muestran infecciones genitales hasta en el 9% de los casos 34 . De manera similar, se ha reportado la co-infección entre Chlamydia pneumoniae y Mycoplasma pneumoniae en infecciones de vías respiratorias en niños menores de 15 años 35 .…”