A cross-over comparison of the effect of morphine, pethidine, pentazocine, and phenazocine on biliary pressure

Economou, G; Ward‐McQuaid, J. N.

doi:10.1136/gut.12.3.218

Cited by 81 publications

(15 citation statements)

References 8 publications

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“…The excitatory effect of morphine on the sphincter of Oddi has been under investigation since the 1970s and has recently been verified by choledochoscope manom- etry [39,40] . Accordingly, morphine is able to increase basal pressure, frequency of phasic contractions and amplitude of phasic contractions of the sphincter of Oddi.…”

Section: Discussionmentioning

confidence: 99%

Effect of Intravenous Morphine Comedication on Bile Duct Visualization, Diameter and Volume Applying Intravenous CT Cholangiography in a Porcine Liver Model

et al. 2010

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Background/Aims: To determine whether intravenous morphine comedication improves bile duct visualization, diameter and/or volume applying intravenous CT cholangiography in a porcine liver model. Methods: 12 Landrace pigs underwent intravenous CT cholangiography. Eight minutes after initiation of the contrast material infusion, either morphine sulfate (n = 6 animals) or normal saline (n = 6 animals) was administered. Eighteen consecutive CT scans of the liver were acquired with 2-min intervals starting with initiation of the contrast material infusion. Maximum bile duct visualization scores, diameters and volumes and time to maximum bile duct visualization scores, diameters and volumes were determined. Results: Maximum bile duct visualization scores, diameters and volumes and time to maximum bile duct visualization scores, diameters and volumes were not significantly different when the morphine group was compared to the normal saline group. Maximum bile duct visualization scores ranged between 4.00 ± 0.00 and 2.83 ± 1.47. Maximum bile duct diameters ranged between 6.77 ± 0.40 and 2.10 ± 1.35 mm. Maximum bile duct volume was 16.41 ± 7.33 ml in the morphine group and 16.79 ± 5.65 ml in the normal saline group. Conclusion: Intravenous morphine comedication failed to improve bile duct visualization and to increase bile duct diameter and volume applying CT cholangiography.

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Section: Discussionmentioning

confidence: 99%

Effect of Intravenous Morphine Comedication on Bile Duct Visualization, Diameter and Volume Applying Intravenous CT Cholangiography in a Porcine Liver Model

et al. 2010

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“…Several studies have been conducted to evaluate the effect of analgesics on biliary pressure [9,11,15] . These studies have suggested that therapeutic doses of morphine and meperidine may cause a marked increase in biliary pressure.…”

Section: Discussionmentioning

confidence: 99%

Investigation of Relaxant Effects of Propofol on Sheep Sphincter of Oddi

et al. 2007

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“…Several studies have been conducted to evaluate the effect of analgesics on biliary pressure [4,[7][8][9] . These studies have suggested that therapeutic doses of morphine and meperidine may cause a marked increase in biliary pressure.…”

Section: Discussionmentioning

confidence: 99%

“…These studies have suggested that therapeutic doses of morphine and meperidine may cause a marked increase in biliary pressure. Most of these studies were performed after cholecystectomy or following catheterization and obstruction of the cystic duct [8][9][10][11] . Coelho et al [12] reported that following administration of morphine and meperidine, biliary pressure did not increase in animals with intact gallbladder.…”

Section: Discussionmentioning

confidence: 99%

In vitro effects of intravenous anesthetics on the sphincter of oddi strips of sheep

et al. 2005

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A cross-over comparison of the effect of morphine, pethidine, pentazocine, and phenazocine on biliary pressure

Cited by 81 publications

References 8 publications

Effect of Intravenous Morphine Comedication on Bile Duct Visualization, Diameter and Volume Applying Intravenous CT Cholangiography in a Porcine Liver Model

Effect of Intravenous Morphine Comedication on Bile Duct Visualization, Diameter and Volume Applying Intravenous CT Cholangiography in a Porcine Liver Model

Investigation of Relaxant Effects of Propofol on Sheep Sphincter of Oddi

In vitro effects of intravenous anesthetics on the sphincter of oddi strips of sheep

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