2015
DOI: 10.1002/ptr.5280
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Abstract: This study attempts a critical evaluation of the clinical evidence behind the use of dietary pomegranate preparations in the prevention and treatment of cardiovascular diseases. A search of PubMed on August 10, 2014 identified 228 references, which yielded extractable data from 24 clinical studies of pomegranate preparations. Hand searching identified two further studies. The quality of the studies and evidence of effectiveness of pomegranate were assessed by an established set of conventional criteria. Overal… Show more

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Cited by 23 publications
(11 citation statements)
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“…Unsaturated fatty acids (Torres‐Moreno et al ., ), flavonoids (Wollgast, ) and theobromine (Franco et al ., ) may also contribute to beneficial cocoa CV effects. When considering the flavanol content, then the HPLC and photometric analyses are not numerically comparable and photometric assessments can overestimate the true content of co‐active compounds (Chrubasik‐Hausmann et al ., , ; Davidson et al ., ; Vlachojannis et al ., , ). Our analysis of the cocoa active components revealed that many compounds need to be considered (Damm et al ., ) to understand the relationship between cocoa and health.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Unsaturated fatty acids (Torres‐Moreno et al ., ), flavonoids (Wollgast, ) and theobromine (Franco et al ., ) may also contribute to beneficial cocoa CV effects. When considering the flavanol content, then the HPLC and photometric analyses are not numerically comparable and photometric assessments can overestimate the true content of co‐active compounds (Chrubasik‐Hausmann et al ., , ; Davidson et al ., ; Vlachojannis et al ., , ). Our analysis of the cocoa active components revealed that many compounds need to be considered (Damm et al ., ) to understand the relationship between cocoa and health.…”
Section: Discussionmentioning
confidence: 99%
“…These were compared with those used in the meta-analyses of the reviews. The individual studies were classified as 'confirmatory' (an adequately controlled and appropriately sized trial where hypotheses were stated in advance) or 'exploratory' (all other studies) in order to evaluate the evidence of effectiveness for the outcomes as previously reported (Chrubasik-Hausmann et al, 2014a, 2014bVlachojannis et al, 2009Vlachojannis et al, , 2010aVlachojannis et al, , 2010bVlachojannis et al, , 2013Vlachojannis et al, , 2015aVlachojannis et al, , 2015bVlachojannis et al, , 2016.…”
Section: Methodsmentioning
confidence: 99%
“…Biochemical markers of dyslipidaemia, insulin resistance/sensitivity, inflammation and oxidative stress are among the modifiable cardiovascular risk markers shown to be responsive to dietary (fruits and vegetables) intervention, but evidence from human intervention trials appears to be limited as most studies called for further research [15,16,17,18,19,20,21,22,23,24,25,26].…”
Section: Introductionmentioning
confidence: 99%
“…Recent studies have suggested that pomegranate has a wide range of beneficial effects against cancer, cardiovascular diseases, diabetes, dental disease, Alzheimer's disease, male infertility, idiopathic heavy menstrual bleeding, and obesity (Jurenka, ; Asgary et al, ; Javan et al, ; Panth et al, ). However, the authenticity of some of these studies has been questioned, and hence, further research has to be done in this area (Vlachojannis et al, ). Based on the powerful antioxidant effects of pomegranate fruit, this study was aimed to examine its protective effect against myocardial ischemia and reperfusion injury in patients hospitalized in cardiac care unit.…”
Section: Introductionmentioning
confidence: 99%