A critical appraisal on ferulic acid: Biological profile, biopharmaceutical challenges and nano formulations

Raj, Naman Deep; Singh, Dilpreet

doi:10.1016/j.hsr.2022.100063

Cited by 26 publications

(19 citation statements)

References 49 publications

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“…Ferulic acid, quercetin, and coumaric acid were the most abundant compounds found in the decoction of A. iva (L.). Various studies have shown the pharmacological properties of ferulic acid as an antioxidant [ 87 , 88 ], antiallergic, anti-inflammatory, hepatoprotective, anticancer, antimicrobial, antiviral, vasodilator, antithrombotic [ 89 ], and antidiabetic [ 90 ]. The same goes for the compound quercetin, which is known to have good anti-inflammatory, antioxidant [ 91 ], antidiabetic [ 92 ], anticancer, antiproliferative, apoptotic [ 93 , 94 ], antimicrobial, and antidiabetic effects [ 95 ].…”

Section: Resultsmentioning

confidence: 99%

Phytochemical Profile, Antioxidant, Antimicrobial, and Antidiabetic Activities of Ajuga iva (L.)

Saidi

Remok

Handaq

et al. 2023

Life

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In Morocco, many applications in ethnomedicine on Ajuga iva (L.) have been recognized as able to treat various pathologies such as diabetes, stress, and microbial infections. The objective of this work is to carry out phytochemical, biological, and pharmacological investigations on the extracts of Ajuga iva leaves in order to confirm its therapeutic effects. The phytochemical screening carried out on the different extracts of Ajuga iva showed its richness in primary (lipids and proteins) and secondary metabolites (flavonoids, tannins, reducing compounds, oses, and holoside. The best contents of polyphenols, flavonoids, and tannins evaluated by spectrophotometric methods were found in the hydroethanolic extract (69.850 ± 2.783 mg EAG/g DE, 17.127 ± 0.474 mg EQ/g DE, 5.566 ± 0.000 mg EQC/g DE), respectively. Analysis of the chemical composition of the aqueous extract by LC/UV/MS revealed 32 polyphenolic compounds including ferulic acid (19.06%), quercetin (10.19%), coumaric acid (9.63%), and apigenin-7-(2-O-apiosylglucoside) (6.8%). The antioxidant activity of Ajuga iva extracts was evaluated by three methods (DPPH*, FRAP, CAT). The hydroethanolic extract recorded the strongest reducing power: DPPH* (IC50 = 59.92 ± 0.7 µg/mL), FRAP (EC50 = 196.85 ± 1.54 (µg/mL), and CAT (199.21 ± 0.37 mg EAG/gE). A strong correlation between phenolic compounds and antioxidant activities was confirmed by the determination of Pearson’s coefficient. The antimicrobial activity of Ajuga iva studied by the microtiter method revealed potent antifungal and antibacterial qualities against Candida parapsilosis and Staphylococcus aureus BLACT. An in vivo oral glucose tolerance test (OGTT) using normal rats revealed that the antihyperglycemic action of the aqueous extract significantly reduced postprandial hyperglycaemia at (30 min, p < 0.01) and area under the curve (AUC glucose), p < 0.01. Similarly, the aqueous extract, tested on pancreatic α-amylase enzyme activity in vitro and in vivo significantly inhibited pancreatic α-amylase activity with IC50 = 1.52 ± 0.03 mg/mL. In conclusion, the extract from Ajuga iva could be a good source of bioactive molecules, which exhibit potent antioxidant and antimicrobial activity, as well as strong antidiabetic activity, for applications in the pharmaceutical industry.

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Section: Resultsmentioning

confidence: 99%

Phytochemical Profile, Antioxidant, Antimicrobial, and Antidiabetic Activities of Ajuga iva (L.)

Saidi

Remok

Handaq

et al. 2023

Life

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“…This amount might be feasibly extracted from approximately 50 g of sugarcane leaves, which otherwise would just be fed to a boiler to generate heat energy. There are some patented ferulic acid–containing products, including a neuroprotective drug and an anti‐hypertensive drug (Raj & Singh, 2022). Apart from this, there are some in vitro and preclinical in vivo data indicating antidiabetic and anti‐cancer properties (Raj & Singh, 2022).…”

Section: Applications In the Food Industry And Potential Health Benefitsmentioning

confidence: 99%

“…There are some patented ferulic acid–containing products, including a neuroprotective drug and an anti‐hypertensive drug (Raj & Singh, 2022). Apart from this, there are some in vitro and preclinical in vivo data indicating antidiabetic and anti‐cancer properties (Raj & Singh, 2022). Caffeic acid has been the subject of considerable research in vitro and in animal models.…”

Section: Applications In the Food Industry And Potential Health Benefitsmentioning

confidence: 99%

Flavonoids and phenolic acids from sugarcane: Distribution in the plant, changes during processing, and potential benefits to industry and health

Hewawansa,

Houghton,

Barber

et al. 2024

Comp Rev Food Sci Food Safe

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Sugarcane (Saccharum sp.) plants are grown in warmer climates throughout the world and processed to produce sugar as well as other useful byproducts such as molasses and bagasse. Sugarcane is rich in (poly)phenols, but there has been no attempt to critically evaluate the published information based on the use of suitable methodologies. The objective of this review is to evaluate the quantitative and qualitative (poly)phenolic profiles of individual parts of the sugarcane plant and its multiple industrial products, which will help develop new processes and uses for sugarcane (poly)phenols. The quantitative analysis involves the examination of extraction, concentration, and analytical techniques used in each study for each plant part and product. The qualitative analysis indicates the identification of various (poly)phenols throughout the sugarcane processing chain, using only compounds elucidated through robust analytical methodologies such as mass spectrometry or nuclear magnetic resonance. In conclusion, sugarcane (poly)phenols are predominantly flavonoids and phenolic acids. The main flavonoids, derivatives of apigenin, luteolin, and tricin, with a substantial proportion of C‐glycosides, are consistently found across all phases of sugarcane processing. The principal phenolic acids reported throughout the process include chlorogenic acids, as well as ferulic and caffeic acids mostly observed after hydrolysis. The derivation of precise quantitative information across publications is impeded by inconsistencies in analytical methodologies. The presence of multiple (poly)phenols with potential benefits for industrial applications and for health suggests sugarcane could be a useful provider of valuable compounds for future use in research and industrial processes.

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“…The ferulic acid molecule reveals cis-trans isomerism, with the most abundant form in nature being the trans isomer, and both isomers have proven results in the treatment of several pathologies such as diabetes, cancer, and neurodegenerative and cardiac diseases [ 302 ]. Ferulic acid is important for the synthesis of significant chemical molecules such as coniferyl alcohol, di ferulic acid, vanillin, synaptic, and curcumin, as well as for giving the cell wall stiffness [ 303 ]. Ferulic acid can be applied as an antioxidant to prevent damage from ultraviolet (UV) radiation and skin carcinogenesis [ 304 ].…”

Section: Hydroxycinnamic Acids ( P -Coumaric Acid ...mentioning

confidence: 99%

Therapeutic Potential of Phenolic Compounds in Medicinal Plants—Natural Health Products for Human Health

2023

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Phenolic compounds and flavonoids are potential substitutes for bioactive agents in pharmaceutical and medicinal sections to promote human health and prevent and cure different diseases. The most common flavonoids found in nature are anthocyanins, flavones, flavanones, flavonols, flavanonols, isoflavones, and other sub-classes. The impacts of plant flavonoids and other phenolics on human health promoting and diseases curing and preventing are antioxidant effects, antibacterial impacts, cardioprotective effects, anticancer impacts, immune system promoting, anti-inflammatory effects, and skin protective effects from UV radiation. This work aims to provide an overview of phenolic compounds and flavonoids as potential and important sources of pharmaceutical and medical application according to recently published studies, as well as some interesting directions for future research. The keyword searches for flavonoids, phenolics, isoflavones, tannins, coumarins, lignans, quinones, xanthones, curcuminoids, stilbenes, cucurmin, phenylethanoids, and secoiridoids medicinal plant were performed by using Web of Science, Scopus, Google scholar, and PubMed. Phenolic acids contain a carboxylic acid group in addition to the basic phenolic structure and are mainly divided into hydroxybenzoic and hydroxycinnamic acids. Hydroxybenzoic acids are based on a C6-C1 skeleton and are often found bound to small organic acids, glycosyl moieties, or cell structural components. Common hydroxybenzoic acids include gallic, syringic, protocatechuic, p-hydroxybenzoic, vanillic, gentistic, and salicylic acids. Hydroxycinnamic acids are based on a C6-C3 skeleton and are also often bound to other molecules such as quinic acid and glucose. The main hydroxycinnamic acids are caffeic, p-coumaric, ferulic, and sinapic acids.

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A critical appraisal on ferulic acid: Biological profile, biopharmaceutical challenges and nano formulations

Cited by 26 publications

References 49 publications

Phytochemical Profile, Antioxidant, Antimicrobial, and Antidiabetic Activities of Ajuga iva (L.)

Phytochemical Profile, Antioxidant, Antimicrobial, and Antidiabetic Activities of Ajuga iva (L.)

Flavonoids and phenolic acids from sugarcane: Distribution in the plant, changes during processing, and potential benefits to industry and health

Therapeutic Potential of Phenolic Compounds in Medicinal Plants—Natural Health Products for Human Health

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