A Cotton Pellet Granuloma Assay for Locally Administered Anti-Inflammatory Drugs: 9 Halo, 21 Desoxy-Corticoids

Hershberger, L. G.; Calhoun, David W.

doi:10.1210/endo-60-1-153

Cited by 14 publications

(2 citation statements)

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“…Removal of the 21-oxygen function from 9a-fluorocortisol considerably reduced the anti-inflammatory potency of the latter steroid (HERSHBERGER and CALHOUN, 1957). The effect of 9a-fluoro substitution in ll-deoxycorticosterone (BERGSTROM and DODSON, 1960b) was to increase mineralocorticoid action (KAGAWA and JACOBS, 1960).…”

Section: Other Pregnane Derivativesmentioning

confidence: 99%

Fluorine-Containing Steroids

ChenJr.¹,

Borrevang²

1970

Pharmacology of Fluorides

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Section: Other Pregnane Derivativesmentioning

confidence: 99%

Fluorine-Containing Steroids

ChenJr.¹,

Borrevang²

1970

Pharmacology of Fluorides

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“…Hitherto, traditional animal models such as cotton pellet granuloma [1] and the croton oil granuloma pouch [2,3] were used for the evaluation of local effects of corticosteroids, which were directly injected into the inflammatory sites. TONELLI and his associates [4] devised the croton oil ear edema method for the determination of topical anti-inflammatory activity in animal models.…”

Section: Introductionmentioning

confidence: 99%

Two simple methods for the evaluation of topically active anti-inflammatory steroidal ointments

et al. 1981

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Simple laboratory methods for quantitating the topical anti-inflammatory activity of steroidal ointments are described. One is of croton oil ear edema in rats and the other is a new method using homologous passive cutaneous anaphylaxis (PCA) in rats. In order to avoid problems such as the animals' licking and/or rubbing the ointment at the applied sites, which might result in oral uptake, each rat was housed individually and fitted with a plastic collar in the croton oil experiment. The sites of ointment application in the PCA experiment were covered with adhesive plaster. Optimal experimental conditions were as follows. In the former method, ointments were applied to the inside surface of the ear 5 min after the irritant treatment and anti-edematous activity was determined after 6 h. In the latter, ointments were applied 3 h before the antigenic challenge to the dorsal area of animals which had been passively sensitized by anti-serum, and inhibition of the increased permeability was determined 45 min after the challenge. These methods were found to be reliable with respect to sensitivity and reproducibility of data. Ointments of halcinonide, betamethasone-17-valerate, hydrocortisone-17-butyrate, fluocinonide, flumethasone-21-pivalate and beclomethasone-17,21-dipropionate were evaluated by these methods.

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Bioassays Used in Development of Topical Dosage Forms

Haleblian¹

1976

Journal of Pharmaceutical Sciences

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A Cotton Pellet Granuloma Assay for Locally Administered Anti-Inflammatory Drugs: 9 Halo, 21 Desoxy-Corticoids

Cited by 14 publications

References 1 publication

Fluorine-Containing Steroids

Fluorine-Containing Steroids

Two simple methods for the evaluation of topically active anti-inflammatory steroidal ointments

Bioassays Used in Development of Topical Dosage Forms

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