2014
DOI: 10.1016/j.cell.2014.01.050
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Abstract: The brain’s response to sensory input is strikingly modulated by behavioral state. Notably, the visual response of mouse primary visual cortex (V1) is enhanced by locomotion, a tractable and accessible example of a time-locked change in cortical state. The neural circuits that transmit behavioral state to sensory cortex to produce this modulation are unknown. In vivo calcium imaging of behaving animals revealed that locomotion activates vasoactive intestinal peptide (VIP)-positive neurons in mouse V1 independe… Show more

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Cited by 817 publications
(1,173 citation statements)
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References 62 publications
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“…Likewise, connections to other amacrine cells were not explored but may be a primary postsynaptic target of some VIP ϩ cells, as found in ultrastructural studies of guinea pig retina (Lee et al, 2002). VIP ϩ interneurons in visual cortex also commonly contact other interneurons (Pfeffer et al, 2013;Pi et al, 2013;Fu et al, 2014).…”
Section: Discussionmentioning
confidence: 99%
“…Likewise, connections to other amacrine cells were not explored but may be a primary postsynaptic target of some VIP ϩ cells, as found in ultrastructural studies of guinea pig retina (Lee et al, 2002). VIP ϩ interneurons in visual cortex also commonly contact other interneurons (Pfeffer et al, 2013;Pi et al, 2013;Fu et al, 2014).…”
Section: Discussionmentioning
confidence: 99%
“…Author manuscript; available in PMC 2017 September 21. Pfeffer et al, 2013;Pi et al, 2013), and enabled studies that revealed the function of this disinhibitory circuit in the context of behavior (Fu et al, 2014;Pi et al, 2013).…”
Section: Vip-flp-mediated Intersectional Targeting Reveals Multiple Smentioning
confidence: 99%
“…ACh favours incoming thalamocortical sensory afferents relative to intracortical pathways [146,147], and combined BF and whisker stimulation increases whisker-evoked LFPs in the barrel cortex [148]. Interestingly, BF-ACh stimulation leads to activation of VIP-containing interneurons during locomotion in the visual cortex [149]. By contrast, BF lesion reduces whiskerevoked activity in the barrel cortex [150].…”
Section: (B) Basal Forebrain Cholinergic Pathway Stimulationevoked Nementioning
confidence: 99%