A conveniently prepared and hypersensitized small molecular fluorescent probe: Rapidly detecting free zinc ion in HepG2 cells and Arabidopsis

Synthesis of Water-Soluble Ag2S Quantum Dots with Fluorescence in the Second Near-Infrared Window for Turn-On Detection of Zn(II) and Cd(II)

“…As the second most abundant transition metal ion in the human body, zinc is considered to play a critical role in many biological processes, such as gene transcription, metalloenzyme catalysis, immune response, and mammalian reproduction. , With most restrained to proteins and enzymes, free zinc ion still can be found in many tissues, such as brain, retina, and intestine . The disorder of Zn 2+ concentration can lead to a series of diseases, including Alzheimer’s, Parkinson’s, ischemic stroke, and kidney stone. , In contrast, cadmium is not only a nonessential element for human body but also can cause many serious diseases and even cancers, despite its similar electronic composition and chemical state as zinc. , Mainly from atmospheric deposition of mining activities and effluent from industrial process, cadmium pollution has shown a huge threat to the environment and human health. , Accordingly, the detection of Zn 2+ and Cd 2+ have been attracting more and more attention. − With advantages of simplicity, high sensitivity, and high profitability, lots of fluorescent probers for these two cations have been investigated. − However, the sensors with fluorescent wavelength in the NIR-II are still less common, which could offer distinct advantages mentioned above. NIR-II fluorescent probers for Zn 2+ based on small molecules have been demonstrated .…”

Subcellular localised small molecule fluorescent probes to image mobile Zn2+

“…The conveniently prepared small molecular uorescent probe 24 included benzothiazole as the uorophore and an ohydroxyl Schiff base as the Zn 2+ receptor. 65 Upon binding Zn 2+ , the PET process was blocked, and the uorescence response had a 65-fold increase with a slight red shi, with a Job's plot showing a 2 : 1 binding stoichiometry between 24 and Zn 2+ . In human liver hepatocellular carcinoma cells, 24 was able to .…”

Recent progress in small-molecule fluorescent probes for endoplasmic reticulum imaging in biological systems

“…23), for Zn 2+ was developed by Zhou's group. 131 This probe was synthesized via the condensation of p-benzothiazole aniline and 4,4-diethylaminesalicylaldehyde. This probe showed a turn-on fluorescence response to Zn 2+ with high sensitivity and selectivity and rapid response time.…”