2012
DOI: 10.3390/molecules17089335
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Abstract: Successful implementation of ultrasound irradiation for the rapid synthesis of a novel series of 3-[1-(4-substituted-5-(aryldiazenyl)thiazol-2-yl)hydrazono)ethyl]-2H-chromen-2-ones 5a–h, via reactions of 2-(1-(2-oxo-2H-chromen-3-yl)ethylidene) thiosemicarbazide (2) and the hydrazonoyl halides 3(4), was demonstrated. Also, a new series of 5-arylidene-2-(2-(1-(2-oxo-2H-chromen-3-yl)ethylidene)hydrazinyl)thiazol-4(5H)-ones 10a–d were synthesized from reaction of 2 with chloroacetic acid and different aldehydes. M… Show more

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Cited by 103 publications
(52 citation statements)
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“…As a part of our research interest towards developing new routes for the synthesis of a variety of heterocyclic systems with promising antitumor activities [9,10,[16][17][18][19][20][21][22], we report in the present work the synthesis of a new series of thiazolyl-thiazoles as promising cytotoxic antitumor drugs.…”
Section: Chemistrymentioning
confidence: 99%
“…As a part of our research interest towards developing new routes for the synthesis of a variety of heterocyclic systems with promising antitumor activities [9,10,[16][17][18][19][20][21][22], we report in the present work the synthesis of a new series of thiazolyl-thiazoles as promising cytotoxic antitumor drugs.…”
Section: Chemistrymentioning
confidence: 99%
“…In earlier literature, Ignat et al [7] synthe-sized that thiosemicarbazide condensed with ethyl-10H-phenothiazine-3-carbaldehyde in microwave condition to yield carbothioamide as product. Khalil et al [8] reported that 3-acetylcoumarin condensed with thiosemicarbazide in ethanol at microwave condition gave 2-(1-(2-oxo-4a,8a-dihydro-2H-chromen-3-yl)-ethylidiene)hydrazinecarbothioamide. Awad et al [9] reported that 2-amino-5-(2-phenyl-1,2,3-triazol-4-yl)-1,3,4-thiadiazole was prepared by the oxidative cyclization of thiosemicarbazone of 4-formyl-1,2,3-triazole with ferric chloride.…”
Section: Introductionmentioning
confidence: 99%
“…The latter was prepared in the laboratory using a reported procedure [8]. Melting points are uncorrected and were determined using open capillary tubes in sulfuric acid bath.…”
Section: Introductionmentioning
confidence: 99%
“…5 Small heterocyclic moieties containing atoms of nitrogen, sulfur and oxygen have been extensively studied due to their diverse biological activities. Sonochemistry has been also studied to the synthesis of heterocycles, such as thiazoles, 6 thiophenes, 7 thiazines 8 and thiadiazines. 9 Our research group and others recently published the efficient ultrasound synthesis of thiazolidinones [10][11][12][13] and thiazolidinediones.…”
Section: Introductionmentioning
confidence: 99%