A Controlled Study of Efficacy of Iproniazid in Treatment of Depression

The Tuberculosis-Depression Syndemic and Evolution of Pharmaceutical Therapeutics: From Ancient Times to the Future

“…Seventy percent of patients institutionalized for depression showed marked improvement and similar improvements were observed in ambulatory patients (27). The term "antidepressant" was coined for the mood elevating properties; by the end of the 1950s, INH was used by an estimated 400,000 psychiatric patients (27,28).…”

Clinical pharmacology of central stimulant and antidepressant drugs

“…In one statistically controlled trial, iproniazid treatment, placebos, and psychotherapy were assigned to three groups of randomly selected, depressed patients; before, and after 6 weeks of treatment, the patients were evaluated by a multidimensional scale for rating psychiatric patients. 64 There was no statistically significant difference between the average final ratings of the three patient groups. Admittedly, this study, although formally complying with the rules of statistical experimental design, may be criticized on the grounds that the patient material consisted of a variety of different diagnostic categories, including most of the psychoses and neuroses and some personality disorders.…”

Altered Microbiota Composition Mediates Depressive Behavior During Chronic Stress

“…restraint, loud white noise, crowded housing, strobe light) and an overnight stressor (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24) hours: 45° cage tilting, repeated cage changes, wet bedding, dark deprivation) presented in a randomized fashion as described in the literature 7 . For restraint stress, mice were placed in clean 50mL conical tubes with pierced holes for ventilation for 1 hour.…”

“…In this context, perhaps unsurprisingly, the first antidepressant drugs, iproniazid and imipramine, were discovered accidentally 11 . Iproniazid was initially used to treat tuberculosis, while imipramine was being tested for schizophrenia, when clinicians observed their mood enhancing effects [11][12][13] .…”