A conducting neural interface of polyurethane/silk-functionalized multiwall carbon nanotubes with enhanced mechanical strength for neuroregeneration

Shrestha, Sita; Shrestha, Bishnu Kumar; Joshua, Lee; Joong, Oh Kwang; Kim, Beom-Su; Park, Chan Hee; Kim, Cheol Sang

doi:10.1016/j.msec.2019.04.053

Cited by 74 publications

(68 citation statements)

References 56 publications

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“…CNTs can be used without giving electrical stimulation as they provide the biomaterial with a differential potential that was found to be effective enough to allow neurite outgrowth and neural regeneration. Shesthra and colleagues developed a polyurethane-silk scaffold added with MWCNTs and demonstrated that it significantly enhanced P12 neural differentiation and maturation with axonal regrowth [155]. SWCNTs can provide enough conductivity properties for neural differentiation.…”

Section: Carbon-based Nanomaterialsmentioning

confidence: 99%

Biomaterials in Neurodegenerative Disorders: A Promising Therapeutic Approach

Bordoni

Scarian

Rey

et al. 2020

IJMS

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Neurodegenerative disorders (i.e., Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and spinal cord injury) represent a great problem worldwide and are becoming prevalent because of the increasing average age of the population. Despite many studies having focused on their etiopathology, the exact cause of these diseases is still unknown and until now, there are only symptomatic treatments. Biomaterials have become important not only for the study of disease pathogenesis, but also for their application in regenerative medicine. The great advantages provided by biomaterials are their ability to mimic the environment of the extracellular matrix and to allow the growth of different types of cells. Biomaterials can be used as supporting material for cell proliferation to be transplanted and as vectors to deliver many active molecules for the treatments of neurodegenerative disorders. In this review, we aim to report the potentiality of biomaterials (i.e., hydrogels, nanoparticles, self-assembling peptides, nanofibers and carbon-based nanomaterials) by analyzing their use in the regeneration of neural and glial cells their role in axon outgrowth. Although further studies are needed for their use in humans, the promising results obtained by several groups leads us to suppose that biomaterials represent a potential therapeutic approach for the treatments of neurodegenerative disorders.

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Section: Carbon-based Nanomaterialsmentioning

confidence: 99%

Biomaterials in Neurodegenerative Disorders: A Promising Therapeutic Approach

Bordoni

Scarian

Rey

et al. 2020

IJMS

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“…As mentioned before, CNTs can be utilized as scaffold reinforcements since they can improve structural integrity and electrical properties, which make them promising for neural regeneration. Association of the functionalized MWCNTs with polyurethane/silk fibroin utilizing the electrospinning technique improves neural extension and differentiation along the direction of the fibers (Shrestha et al 2019).…”

Section: Carbon Nanotubesmentioning

confidence: 99%

Nanomaterial integration into the scaffolding materials for nerve tissue engineering: a review

Arzaghi

Adel

Jafari

et al. 2020

Reviews in the Neurosciences

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The nervous system, which consists of a complex network of millions of neurons, is one of the most highly intricate systems in the body. This complex network is responsible for the physiological and cognitive functions of the human body. Following injuries or degenerative diseases, damage to the nervous system is overwhelming because of its complexity and its limited regeneration capacity. However, neural tissue engineering currently has some capacities for repairing nerve deficits and promoting neural regeneration, with more developments in the future. Nevertheless, controlling the guidance of stem cell proliferation and differentiation is a challenging step towards this goal. Nanomaterials have the potential for the guidance of the stem cells towards the neural lineage which can overcome the pitfalls of the classical methods since they provide a unique microenvironment that facilitates cell–matrix and cell–cell interaction, and they can manipulate the cell signaling mechanisms to control stem cells’ fate. In this article, the suitable cell sources and microenvironment cues for neuronal tissue engineering were examined. Afterward, the nanomaterials that impact stem cell proliferation and differentiation towards neuronal lineage were reviewed.

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“…Using graphite nanoplatelets as fillers in electrospun polystyrene nanofibers which were cold-and hot-pressed after spinning, Guo et al reached a higher value of approximately 1 S/cm for the highest graphite loading, as depicted in Figure 3 [23]. Shrestha et al included functionalized multi-wall CNTs in a polyurethane/silk spinning solution and found conductivities of nearly 60 µS/cm for the resulting nanofiber mats, as compared to values below 1 µS/cm for pure polyurethane (PU) or PU/silk nanofiber mats [24]. Combining electrospraying of polyurethane (PU) with simultaneous electrospraying of multi-wall CNTs, Shokraei et al reached conductivities between 10 −5 and 10 −2 S/cm, as compared to the conductivity of the pure isolating PU of 10 −10 S/cm [25].…”

Section: Electrospinning From Conductive Solutions or Meltsmentioning

confidence: 99%

Conductive Electrospun Nanofiber Mats

Błachowicz

Ehrmann

2019

Materials

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Conductive nanofiber mats can be used in a broad variety of applications, such as electromagnetic shielding, sensors, multifunctional textile surfaces, organic photovoltaics, or biomedicine. While nanofibers or nanofiber from pure or blended polymers can in many cases unambiguously be prepared by electrospinning, creating conductive nanofibers is often more challenging. Integration of conductive nano-fillers often needs a calcination step to evaporate the non-conductive polymer matrix which is necessary for the electrospinning process, while conductive polymers have often relatively low molecular weights and are hard to dissolve in common solvents, both factors impeding spinning them solely and making a spinning agent necessary. On the other hand, conductive coatings may disturb the desired porous structure and possibly cause problems with biocompatibility or other necessary properties of the original nanofiber mats. Here we give an overview of the most recent developments in the growing field of conductive electrospun nanofiber mats, based on electrospinning blends of spinning agents with conductive polymers or nanoparticles, alternatively applying conductive coatings, and the possible applications of such conductive electrospun nanofiber mats.

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A conducting neural interface of polyurethane/silk-functionalized multiwall carbon nanotubes with enhanced mechanical strength for neuroregeneration

Cited by 74 publications

References 56 publications

Biomaterials in Neurodegenerative Disorders: A Promising Therapeutic Approach

Biomaterials in Neurodegenerative Disorders: A Promising Therapeutic Approach

Nanomaterial integration into the scaffolding materials for nerve tissue engineering: a review

Conductive Electrospun Nanofiber Mats

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