A concise review on analytical profile of Vigabatrin

Patil, Vikas R.; Sarode, Vinay V.; Chaudhari, Yogesh A.; Patil, Sudhir G.; Tadavi, Samir B.; Patil, None Rohit S.

doi:10.30574/wjarr.2023.17.2.0178

World J. Adv. Res. Rev.

2023

DOI: 10.30574/wjarr.2023.17.2.0178

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A concise review on analytical profile of Vigabatrin

Vikas R. Patil¹,

Vinay V. Sarode²,

Yogesh A. Chaudhari³

et al.

Abstract: Vigabatrin (VGB) is a drug of Anticonvulsant class. It works by decreasing abnormal electrical activity in the brain. It inhibits the GABA-degrading enzyme i.e. GABA transaminase, it increases the GABA concentrations in the brain. Vigabatrin is used for the treatment of refractory complex partial seizures in adults and also used for children 2 years of age and older and infantile spasms in children. Vigabatrin was approved for anticonvulsant medication by USFDA on August 21, 2009. Therefore, in the present rev… Show more

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2024

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Rapid Quantitation of Non-chromophoric Vigabatrin and Gabapentin by a Validated qNMR Method in Bulk Drug and Marketed Formulations

Bedage,

Sahu,

Singh

2024

CPA

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Background:: Vigabatrin and gabapentin, commonly used antiepileptic drugs in clinics, lack a UV active chromophore and, therefore, require cumbersome derivatization methods for analysis by HPLC using fluorescence detection. This study demonstrated the use of NMR for their quantitative determination in pure form and their pharmaceutical formulations. Objective:: To develop a validated qNMR method for non-chromophoric drugs Vigabatrin and Gabapentin. Methods:: The signal of methine proton of vigabatrin at 3.67 ppm relative to the signal of maleic acid at 6.17 ppm and the methylene signal of gabapentin at 2.88 ppm relative to the signal of caffeine at 7.75 ppm was used for qNMR. The developed method was validated with respect to linearity, limits of detection and quantitation, accuracy, precision, specificity and solution state stability. Results:: Linearity range and r2 were found to be from 2.66 to 42.11 mg/mL and 0.9999. The limit of detection and quantification were 0.0129 mg/mL and 0.0391 mg/mL, respectively, for vigabatrin. This method was found to be linear (0.9998) and specific within the gabapentin concentration range from 1.07 to 34.24 mg/mL of D2O. The limits of detection and quantification were 0.0248 mg/mL and 0.0751 mg/mL, respectively. Conclusion:: Both methods were highly precise, with a calculated RSD of 0.60 % and 0.76 %, respectively. The robustness of the methods was revealed by changing pre and post-processing NMR parameters. The developed methods provide a simple and straight approach for the absolute determination of gabapentin and vigabatrin in bulk drugs and their marketed formulations without any pre-procedures.

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Rapid Quantitation of Non-chromophoric Vigabatrin and Gabapentin by a Validated qNMR Method in Bulk Drug and Marketed Formulations

Bedage,

Sahu,

Singh

2024

CPA

View full text Add to dashboard Cite

show abstract

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A concise review on analytical profile of Vigabatrin

Cited by 1 publication

References 11 publications

Rapid Quantitation of Non-chromophoric Vigabatrin and Gabapentin by a Validated qNMR Method in Bulk Drug and Marketed Formulations

Rapid Quantitation of Non-chromophoric Vigabatrin and Gabapentin by a Validated qNMR Method in Bulk Drug and Marketed Formulations

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