A Concise Review of Silver Diamine Fluoride on Oral Biofilm

Abstract

Studies have shown that silver diamine fluoride (SDF) is an effective agent to arrest and prevent dental caries due to its mineralizing and antibacterial properties. While plenty of studies have investigated the mineralizing properties, there are few papers that have examined its antibacterial effect on oral biofilm. The objective of this study was to identify the effect of silver diamine fluoride on oral biofilm. Method: The keywords used were (silver diamine fluoride OR silver diammine fluoride OR SDF OR silver fluoride OR AgF AND biofilm OR plaque). Two reviewers screened the titles and abstracts and then retrieved the full text of the potentially eligible publications. Publications of original research investigating the effect of SDF on oral biofilm were selected for this review. Results: This review included 15 laboratory studies and six clinical studies among the 540 papers identified. The laboratory studies found that SDF could prevent bacterial adhesion to the tooth surface. SDF also inhibited the growth of cariogenic bacteria, including Streptococcus mutans, Lactobacillus acidophilus, Streptococcus sobrinus, Lactobacillus rhamnosus, Actinomyces naeslundii, and Enterococcus faecalis, thus contributing to its success in caries arrest. One clinical study reported a decrease in Streptococcus mutans and Lactobacillus sp. in arrested caries after SDF treatment, and another clinical study found that SDF inhibited the growth of periodontitis microbiota, including Porphyromonas gingivalis, Tannerella forsythia, and Prevotella intermedia/nigrescens. However, three clinical studies reported no significant change in the microbial diversity of the plaque on the tooth after SDF treatment. Moreover, one laboratory study and one clinical research study reported that SDF inhibited the growth of Candida albicans. Conclusion: Not many research studies have investigated the effects of SDF on oral biofilm, although SDF has been used as a caries-arresting agent with antibacterial properties. However, a few publications have reported that SDF prevented bacterial adhesion to the teeth, inhibited the growth of cariogenic and periodontal bacteria, and possessed antifungal properties.

Eradication of Candida albicans Biofilm Viability: In Vitro Combination Therapy of Cationic Carbosilane Dendrons Derived from 4-Phenylbutyric Acid with AgNO3 and EDTA

“…Indeed, the combination therapy was able to completely kill cells and eradicate an established biofilm at a much lower concentration of 32 mg/L of AgNO 3 and 32 mg/L of ArCO 2 G 2 (SNMe 3 I) 4 (2) (Table 2). The anti-microbial effect of silver has been reported previously by other authors against planktonic cells and biofilms [21,27,57,58]. (2) and EDTA indicate that it was possible to reduce the MFC value for both compounds using 8 mg/L and 256 mg/L, respectively.…”

Evaluation of Antibacterial Effect of Silver Diamine Fluoride and Sodium Fluoride Varnish on Bacterial Biofilm (An In Vitro Study)

“…According to Mei et al, (28) Silver diamine fluoride (SDF) has been clinically successful in halting dentin caries; hence, this study sought to determine how it works. On dentin carious lesions, 38% SDF suppresses the growth of multispecies cariogenic biofilms (29) . SDF is regarded as a useful tool for halting caries as a result.…”

Antibacterial Effects of Silver Fluoride and Difluorosilane-based Varnish on Streptococcus mutans

“…Various types of microorganisms in the mouth form dental biofilms when they are placed on the surface of teeth and mucous membranes, causing chronic diseases such as dental caries and periodontitis. Acids produced as a result of microbial metabolism in dental biofilms acidify the oral cavity environment, resulting JKAPD in demineralization of the tooth surface and dental caries [1,2].…”