A comprehensive study on seroprevalence of bluetongue virus in Haryana state of India

Maan, Sushila; Tiwari, Anuj; Chaudhary, Deepika; Dalal, Anita; Bansal, Nitish; Kumar, Vinay; Batra, Kanisht; Kumar, Aman; Kakker, N. K.; Maan, Narender S.

doi:10.14202/vetworld.2017.1464-1470

Cited by 13 publications

(12 citation statements)

References 24 publications

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“…BTV seroprevalence of varying percentages was reported by several authors before [11][12][13][14][15][16][17]. In BT endemic countries such as India, high seroprevalence (>50%) is usually reported [18][19][20][21][22]. Especially, in the tested region included in the present study, the previous studies reported 61% seroprevalence of BTV during 2005-2009 and 75% during 2014-2017 [5,23,24].…”

Section: Discussionsupporting

confidence: 48%

Type-specific seroprevalence of bluetongue in India during 2018 and 2019

et al. 2020

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Background and Aim: Bluetongue (BT) is a major disease of sheep and goats and is endemic to India. It is known to cause significant economic losses to the sheep industry. The current study aimed to determine the type-specific seroprevalence of BT in sheep population of India during 2018-2019. Materials and Methods: Blood samples (n=405) were collected from 6 months to 1 year old sheep from six districts (Nalgonda, Karimnagar, Khammam, Mahabubnagar, Warangal, and Ranga Reddy) of Telangana state, India. Group- and type-specific seroprevalence (against BT virus [BTV] serotypes BTV-1, 2, 4, 5, 9, 10, 12, 16, 21, 23, and 24) was studied by competitive enzyme-linked immunosorbent assay and serum neutralization test, respectively. Results: Results showed an overall seroprevalence of 14.81% (n=60) with the highest seroprevalence of 50% in Khammam district. Seroprevalence of BTV-1, 2, 4, 5, 9, 10, 12, 16, 21, 23, and 24 was noted as 16.66%, 11.66%, 31.66%, 11.66%, 05%, 6.66%, 16.66%, 8.33%, 13.33%, 6.66%, and 16.66%, respectively. The majority of the sera neutralized more than 1 serotype, indicating superinfection or circulation of multiple serotypes in the sampled flocks. This mixed seroprevalence was observed in 43.33% of the sera with number of BTV serotype-specific antibodies ranging from two to eight in individual animals. Conclusion: Regular monitoring of circulating serotypes, especially in young herds, elucidates pattern of dominating serotypes in a particular area during a season. This knowledge can be applied to design appropriate vaccination strategies by including particular serotypes of virus as part of a multivalent vaccine for a particular period, in a particular area.

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Section: Discussionsupporting

confidence: 48%

Type-specific seroprevalence of bluetongue in India during 2018 and 2019

et al. 2020

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“…Serological data show that twenty-two BTV serotypes exist in India, making it a region with one of the highest levels of BTV diversity in the world (Rao et al. 2016; Maan et al. 2017).…”

Section: Introductionmentioning

confidence: 99%

Contrasting selective patterns across the segmented genome of bluetongue virus in a global reassortment hotspot

et al. 2019

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For segmented viruses, rapid genomic and phenotypic changes can occur through the process of reassortment, whereby co-infecting strains exchange entire segments creating novel progeny virus genotypes. However, for many viruses with segmented genomes, this process and its effect on transmission dynamics remain poorly understood. Here, we assessed the consequences of reassortment for selection on viral diversity through time using bluetongue virus (BTV), a segmented arbovirus that is the causative agent of a major disease of ruminants. We analysed ninety-two BTV genomes isolated across four decades from India, where BTV diversity, and thus opportunities for reassortment, are among the highest in the world. Our results point to frequent reassortment and segment turnover, some of which appear to be driven by selective sweeps and serial hitchhiking. Particularly, we found evidence for a recent selective sweep affecting segment 5 and its encoded NS1 protein that has allowed a single variant to essentially invade the full range of BTV genomic backgrounds and serotypes currently circulating in India. In contrast, diversifying selection was found to play an important role in maintaining genetic diversity in genes encoding outer surface proteins involved in virus interactions (VP2 and VP5, encoded by segments 2 and 6, respectively). Our results support the role of reassortment in driving rapid phenotypic change in segmented viruses and generate testable hypotheses for in vitro experiments aiming at understanding the specific mechanisms underlying differences in fitness and selection across viral genomes.

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“…10, 14, 16, 30, 40), and one each in cattle (study no 21) and buffaloes (study no 9). Among the studies which contributed to overall heterogeneity, one study each in sheep (study no 37, Doddamani and HariBabu 2006 ) and in buffaloes (study no 9, Maan et al 2017 ) was identified as an influential study. The sensitivity analysis after removing the influential studies revealed that the seroprevalence was marginally increased in sheep from 44% to 46% while decreased from 34% to 31% in buffaloes.…”

Section: Resultsmentioning

confidence: 99%

“…Even though AGID was a prescribed test for international trade, it lacks sensitivity, specificity and cross reacts with other Orbivirus serogroups, (Hamblin 2004 ). The serological response in BTV infection usually appears 7–14 days’ post-infection, and the antibodies can persist between 2 weeks and 6 years after infection (Eschbaumer et al 2012 ; Maan et al 2017 ). In common, BT seroprevalence in different animals is done either using AGID assay or c-ELISA (OIE 2012).…”

Section: Discussionmentioning

confidence: 99%

Bluetongue in India: a systematic review and meta-analysis with emphasis on diagnosis and seroprevalence

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Vinodhkumar

Karthikeyan

et al. 2020

Veterinary Quarterly

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Bluetongue (BT) is an infectious viral disease which affects a wide range of ruminants and was first reported in India in 1964. In view of the absence of comprehensive information on the BT status in India, this study presents the seroprevalence on BT in farm animals of India based-on a systematic review and meta-analysis. A systematic review was conducted to identify the published articles (2001-2018) reporting the seroprevalence of BT in sheep, goats, cattle, buffalo, camels, and Mithun (Bos frontalis) from India. From 409 research articles, 71 fulfilled the inclusion criteria and meta-analysis for proportions was carried out targeting the eligible studies. From these, 144 strata level data were extracted with a sample size of 14048 sheep, 14696 goats, 5218 cattle, 2653 buffaloes, 2062 camels, and 222 Mithun. Overall, the analyses showed that the BT seroprevalence of 43% (95% CI: 38-49%) in goats, 39% (95% CI: 33-46%) in sheep, 38% (95% CI: 25-45%) in cattle, 34% (95% CI: 20-51%) in buffaloes, 16% (95% CI: 10-22%) in camels, and 66% (95% CI: 17-95%) in Mithun. Furthermore, the meta-regression analysis suggested that serological tests, geographical region, and sample size were the prime moderators. Meta-analytic study indicates the BT seropositivity in 25.35 million sheep (95% CI: 21.5-29.9), 58 million goats (95% CI: 51.3-66.2), 66.8 million cattle (95% CI: 47.7-86), 37.0 million buffaloes (95% CI: 21.7-55.4), 0.06 million camels (95% CI: 0.04-0.09), and 0.19 million Mithun (95% CI: 0.05-0.28). The findings highlight the variation of BT seropositivity in different geographical regions of India.

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A comprehensive study on seroprevalence of bluetongue virus in Haryana state of India

Cited by 13 publications

References 24 publications

Type-specific seroprevalence of bluetongue in India during 2018 and 2019

Type-specific seroprevalence of bluetongue in India during 2018 and 2019

Contrasting selective patterns across the segmented genome of bluetongue virus in a global reassortment hotspot

Bluetongue in India: a systematic review and meta-analysis with emphasis on diagnosis and seroprevalence

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