A Comprehensive Review of the Natural History of Helicobacter pylori Infection in Children

Torres, Javier; Pérez-Pérez, Guillermo I.; Goodman, Karen J.; Atherton, John C.; Gold, Benjamin D.; Harris, Paul; Garza, Armando Madrazo-de la; Guarner, Jeannette; Muñoz, Onofre

doi:10.1016/s0188-4409(00)00099-0

Cited by 221 publications

(212 citation statements)

References 314 publications

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“…The prevalence is much higher elsewhere. For example, in Bangladesh, Ͼ50% of 2-to 9-year-old children from rural families are infected (1)(2)(3). Once acquired in childhood, this bacterium is able to establish a life-long relationship with its host (4).…”

Section: N the United States And Canada As Well As In Northern Andmentioning

confidence: 99%

The complete genome sequence of a chronic atrophic gastritis Helicobacter pylori strain: Evolution during disease progression

Oh¹,

Kling-Bäckhed

Giannakis

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

227

200

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Helicobacter pylori produces acute superficial gastritis in nearly all of its human hosts. However, a subset of individuals develops chronic atrophic gastritis (ChAG), a condition characterized in part by diminished numbers of acid-producing parietal cells and increased risk for development of gastric adenocarcinoma. Previously, we used a gnotobiotic transgenic mouse model with an engineered ablation of parietal cells to show that loss of parietal cells provides an opportunity for a H. pylori isolate from a patient with ChAG (HPAG1) to bind to, enter, and persist within gastric stem cells. This finding raises the question of how ChAG influences H. pylori genome evolution, physiology, and tumorigenesis. Here we describe the 1,596,366-bp HPAG1 genome. Custom HPAG1 Affymetrix GeneChips, representing 99.6% of its predicted ORFs, were used for whole-genome genotyping of additional H. pylori ChAG isolates obtained from Swedish patients enrolled in a casecontrol study of gastric cancer, as well as ChAG-and cancerassociated isolates from an individual who progressed from ChAG to gastric adenocarcinoma. The results reveal a shared gene signature among ChAG strains, as well as genes that may have been lost or gained during progression to adenocarcinoma. Wholegenome transcriptional profiling of HPAG1's response to acid during in vitro growth indicates that genes encoding components of metal uptake and utilization pathways, outer membrane proteins, and virulence factors are among those associated with H. pylori's adaptation to ChAG. acid regulation ͉ comparative microbial genomics ͉ ecogenomics ͉ functional genomics ͉ gastric cancer

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Section: N the United States And Canada As Well As In Northern Andmentioning

confidence: 99%

The complete genome sequence of a chronic atrophic gastritis Helicobacter pylori strain: Evolution during disease progression

Oh¹,

Kling-Bäckhed

Giannakis

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

227

200

View full text Add to dashboard Cite

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“…Gastroduodenal diseases associated with H. pylori occur mainly in adults. Nevertheless, the infection is usually acquired during childhood (Wotherspoon et al 1993) and it is possible that the humoral and mucosal tissue responses at that time can determine the natural course of the infection (Torres et al 2000).…”

mentioning

confidence: 99%

“…It has been reported at a worldwide level that H. pylori infection prevalence in children varies between 10% and 80% (Vaira et al 1994, Torres et al 2000. The lowest prevalence has been found in populations in Northern and Eastern Europe, Japan and other parts of Asia.…”

mentioning

confidence: 99%

“…The lowest prevalence has been found in populations in Northern and Eastern Europe, Japan and other parts of Asia. High prevalence has been well documented in India and Bangladesh and in certain cities of Africa and Latin America (Torres et al 2000).…”

mentioning

confidence: 99%

“…Again increase with age, low socio-economic and educational levels, race, crowded living quarters, migration from high prevalence regions, background of H. pylori-infected family members, poor nutritional state indicators, ingestion of water and vegetables which do not fulfill hygienic conditions, have been reported as risk factors for the increase of H. pylori infection (Graham et al 1991, Smoat et al 1994, Torres et al 2000.…”

mentioning

confidence: 99%

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