2013
DOI: 10.6061/clinics/2013(sup01)06
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Abstract: Azoospermia due to obstructive and non-obstructive mechanisms is a common manifestation of male infertility accounting for 10-15% of such cases. Known genetic factors are responsible for approximately 1/3 of cases of azoospermia. Nonetheless, at least 40% of cases are currently categorized as idiopathic and may be linked to unknown genetic abnormalities. It is recommended that various genetic screening tests are performed in azoospermic men, given that their results may play vital role in not only identifying … Show more

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Cited by 140 publications
(284 citation statements)
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References 281 publications
(284 reference statements)
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“…(2) Non-obstructive azoospermia (NOA) accounting for approximately 60% of men with azoospermia, in which spermatogenesis is inactive and thus sperm cells are not generated. The pathophysiology of NOA is characterised by the absence of sperm cells due to a Sertoli cell-only histology pattern, where only Sertoli cells line the seminiferous tubules (Sertoli cell-only syndrome (SCOS), maturation arrest, where spermatogenesis is not complete and may be arrested at one or more levels of spermatogenesis; hypospermatogenesis, where complete spermatogenesis is present but only few mature sperm cells can be observed or mixed patterns 4. NOA is a severe form of male infertility, with limited treatment options and low fertility success rates 2…”
Section: Introductionmentioning
confidence: 99%
“…(2) Non-obstructive azoospermia (NOA) accounting for approximately 60% of men with azoospermia, in which spermatogenesis is inactive and thus sperm cells are not generated. The pathophysiology of NOA is characterised by the absence of sperm cells due to a Sertoli cell-only histology pattern, where only Sertoli cells line the seminiferous tubules (Sertoli cell-only syndrome (SCOS), maturation arrest, where spermatogenesis is not complete and may be arrested at one or more levels of spermatogenesis; hypospermatogenesis, where complete spermatogenesis is present but only few mature sperm cells can be observed or mixed patterns 4. NOA is a severe form of male infertility, with limited treatment options and low fertility success rates 2…”
Section: Introductionmentioning
confidence: 99%
“…Nonobstructive azoospermia (NOA), in which the testicles fail to produce mature sperm in the ejaculate because of abnormal spermatogenesis, accounts for approximately onehalf of azoospermia cases (2,3). NOA is a heterogeneous disorder caused by complex genetic and environmental factors.…”
mentioning
confidence: 99%
“…USP26 gene, located on Xq26.2 region is expressed throughout the testes in the preliminary stages of spermatogenesis [11]. Any mutation in this gene results in the severe impairment of spermatogenesis [12]. Another gene DIAPH2 located at Xq22 region which affects spermatogenesis is disrupted due to deletion at Xq21.3.…”
Section: Discussionmentioning
confidence: 99%