A Comprehensive Review of Current Perspectives on Novel Drug Delivery Systems and Approaches for Lung Cancer Management

Hani, Umme; Begum, M. Yasmin; Wahab, Shadma; Siddiqua, Ayesha; Osmani, Riyaz Ali M.; Rahmathulla, Mohamed

doi:10.1007/s12247-021-09582-1

Cited by 11 publications

(9 citation statements)

References 199 publications

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“…Studies comparing the makeup of the lung microbiome in healthy and diseased states have shown substantial variations [ 115 , 116 ]. Lung disease has reduced bacterial diversity, with a single taxon or small group dominating [ 117 , 118 ]. It has been shown that age-related changes in composition and diversity in the gut microbiota were seen in cross-sectional research involving individuals from various age groups [ 119 ].…”

Section: Role Of Probiotics In Respiratory Tract Infectionsmentioning

confidence: 99%

Pharmacological Efficacy of Probiotics in Respiratory Viral Infections: A Comprehensive Review

Wahab

Almaghaslah

Mahmood

et al. 2022

JPM

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Mortality and morbidity from influenza and other respiratory viruses are significant causes of concern worldwide. Infections in the respiratory tract are often underappreciated because they tend to be mild and incapacitated. On the other hand, these infections are regarded as a common concern in clinical practice. Antibiotics are used to treat bacterial infections, albeit this is becoming more challenging since many of the more prevalent infection causes have acquired a wide range of antimicrobial resistance. Resistance to frontline treatment medications is constantly rising, necessitating the development of new antiviral agents. Probiotics are one of several medications explored to treat respiratory viral infection (RVI). As a result, certain probiotics effectively prevent gastrointestinal dysbiosis and decrease the likelihood of secondary infections. Various probiotic bacterias and their metabolites have shown immunomodulating and antiviral properties. Unfortunately, the mechanisms by which probiotics are effective in the fight against viral infections are sometimes unclear. This comprehensive review has addressed probiotic strains, dosage regimens, production procedures, delivery systems, and pre-clinical and clinical research. In particular, novel probiotics’ fight against RVIs is the impetus for this study. Finally, this review may explore the potential of probiotic bacterias and their metabolites to treat RVIs. It is expected that probiotic-based antiviral research would be benefitted from this review’s findings.

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Section: Role Of Probiotics In Respiratory Tract Infectionsmentioning

confidence: 99%

Pharmacological Efficacy of Probiotics in Respiratory Viral Infections: A Comprehensive Review

Wahab

Almaghaslah

Mahmood

et al. 2022

JPM

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“…Cancer is one of the leading diseases affecting human life and is caused by various reasons, such as environmental pollution and unhealthy lifestyle. [103][104][105][106] Apoptotic cell death is known to regulate cancer cell proliferation, invasion and survival.…”

Section: Apoptosis and Cell Cycle Arrestmentioning

confidence: 99%

“…Cancer is one of the leading diseases affecting human life and is caused by various reasons, such as environmental pollution and unhealthy lifestyle. 103–106 Apoptotic cell death is known to regulate cancer cell proliferation, invasion and survival. Intrinsic and extrinsic apoptosis are the two major pathways induced by chemotherapeutics to inhibit tumor proliferation ( Figure 3 ).…”

Section: Introductionmentioning

confidence: 99%

Licorice (Glycyrrhiza glabra L.)-Derived Phytochemicals Target Multiple Signaling Pathways to Confer Oncopreventive and Oncotherapeutic Effects

Tuli¹,

Garg²,

Mehta³

et al. 2022

OTT

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Cancer is a highly lethal disease, and its incidence has rapidly increased worldwide over the past few decades. Although chemotherapeutics and surgery are widely used in clinical settings, they are often insufficient to provide the cure for cancer patients. Hence, more effective treatment options are highly needed. Although licorice has been used as a medicinal herb since ancient times, the knowledge about molecular mechanisms behind its diverse bioactivities is still rather new. In this review article, different anticancer properties (antiproliferative, antiangiogenic, antimetastatic, antioxidant, and anti-inflammatory effects) of various bioactive constituents of licorice ( Glycyrrhiza glabra L.) are thoroughly described. Multiple licorice constituents have been shown to bind to and inhibit the activities of various cellular targets, including B-cell lymphoma 2, cyclin-dependent kinase 2, phosphatidylinositol 3-kinase, c-Jun N-terminal kinases, mammalian target of rapamycin, nuclear factor-κB, signal transducer and activator of transcription 3, vascular endothelial growth factor, and matrix metalloproteinase-3, resulting in reduced carcinogenesis in several in vitro and in vivo models with no evident toxicity. Emerging evidence is bringing forth licorice as an anticancer agent as well as bottlenecks in its potential clinical application. It is expected that overcoming toxicity-related obstacles by using novel nanotechnological methods might importantly facilitate the use of anticancer properties of licorice-derived phytochemicals in the future. Therefore, anticancer studies with licorice components must be continued. Overall, licorice could be a natural alternative to the present medication for eradicating new emergent illnesses while having just minor side effects.

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“…Cancer is the second leading cause of death worldwide, and it is anticipated that during the next few years, it will become the top cause of death [ 161 , 162 , 163 ]. Investigators have been looking at possible biological molecules to treat cancer as alternative treatment options [ 164 , 165 , 166 ]. P. kurroa extracts and their components may protect against cancer through many cellular and molecular processes in various disorders.…”

Section: Classical and Clinical Use Of P Kurroamentioning

confidence: 99%

Pharmacological and Clinical Efficacy of Picrorhiza kurroa and Its Secondary Metabolites: A Comprehensive Review

2022

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Traditional remedies for the treatment of various ailments are gaining popularity. Traditionally, one of the most valuable therapeutic herbs has been Picrorhiza kurroa Royle ex Benth. Traditional and folk uses of P. kurroa include chronic constipation, skin-related problems, burning sensation, chronic reoccurring fever, jaundice, heart problems, breathing, digestion, allergy, tuberculosis, blood-related problems, prediabetes and obesity, laxative, cholagogue, and liver stimulatory. Phytoconstituents such as glycosides, alkaloids, cucurbitacins, iridoids, phenolics, and terpenes in P. kurroa have shown promising pharmacological potential. In order to uncover novel compounds that may cure chronic illnesses, such as cardiovascular, diabetes, cancer, respiratory, and hepatoprotective diseases, the screening of P. kurroa is essential. This study comprehensively evaluated the ethnopharmacological efficacy, phytochemistry, pharmacological activity, dose, and toxicity of P. kurroa. This review provides comprehensive insights into this traditional medication for future research and therapeutic application. The purpose of this review article was to determine the pharmacological effects of P. kurroa on a variety of disorders. P. kurroa may be a natural alternative to the standard treatment for eradicating newly evolving diseases. This study is intended as a resource for future fundamental and clinical investigations.

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A Comprehensive Review of Current Perspectives on Novel Drug Delivery Systems and Approaches for Lung Cancer Management

Cited by 11 publications

References 199 publications

Pharmacological Efficacy of Probiotics in Respiratory Viral Infections: A Comprehensive Review

Pharmacological Efficacy of Probiotics in Respiratory Viral Infections: A Comprehensive Review

Licorice (Glycyrrhiza glabra L.)-Derived Phytochemicals Target Multiple Signaling Pathways to Confer Oncopreventive and Oncotherapeutic Effects

Pharmacological and Clinical Efficacy of Picrorhiza kurroa and Its Secondary Metabolites: A Comprehensive Review

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