A Comprehensive Psychopathological Rating Scale

Åsberg, Marie; Montgomery, Stuart; Perris, C.; Schalling, Daisy; Sedvall, Göran

doi:10.1111/j.1600-0447.1978.tb02357.x

Cited by 1,170 publications

(466 citation statements)

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“…Both in 2000-2001 and in 2005-2006, trained psychiatric research nurses performed the semistructured neuropsychiatric examinations that included ratings of the past month's psychiatric signs and symptoms according to Comprehensive Psychopathological Rating Scale (Asberg et al, 1978), which is valid and reliable in elderly populations (van der Laan et al, 2005), and Mini-International Neuropsychiatric Interview (Sheehan et al, 1998), history of depression, and assessment of current medications. Ratings of common signs and symptoms of dementia were also carried out (eg, assessments of memory, orientation, general knowledge, apraxia, visuospatial function, understanding proverbs, following commands, naming ability, and language) and have been described in detail (Guo et al, 2007;Skoog et al, 1993).…”

Section: Neuropsychiatric Examinations and Interviewsmentioning

confidence: 99%

Temporal Lobe Atrophy and White Matter Lesions are Related to Major Depression over 5 years in the Elderly

Olesen

Gustafson

Simoni

et al. 2010

Neuropsychopharmacol

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The influence of organic brain changes on the development of depression in the elderly is uncertain. Cross-sectional studies, most often from clinical samples, report associations with brain atrophy and cerebrovascular disease, while longitudinal population studies have given mixed results. Our aim was to investigate whether cortical atrophy and white matter lesions (WMLs) on computed tomography (CT) predict occurrence of depression in the elderly. This is a prospective population-based study with 5-year follow-up. The baseline sample included 525 elderly subjects, aged 70-86 years, without dementia or major depression, with a score on the Mini-Mental State Examination above 25, and without dementia at follow-up. Cortical atrophy and WMLs were evaluated at baseline using CT. The main outcome measure was development of major or minor depression at follow-up according to Diagnostic and Statistical Manual of Mental Disorders, fourth edition, as evaluated using neuropsychiatric examinations and hospital discharge registers. Logistic regression was used to estimate risk. Over the period of 5 years, 20 individuals developed major and 63 minor depression. Presence of temporal lobe atrophy (odds ratio (OR) ¼ 2.81, 95% confidence interval (CI) 1.04-7.62) and moderate-to-severe WMLs (OR ¼ 3.21, 95% CI 1.00-10.26) independently predicted major, but not minor, depression after controlling for various confounders. Other brain changes did not predict occurrence of depression. Our findings suggest that temporal lobe atrophy and WMLs represent relatively independent and complementary pathways to major depression in the elderly. This may have implications for prevention, as both neurodegeneration and cerebrovascular disease have been related to preventable factors.

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Section: Neuropsychiatric Examinations and Interviewsmentioning

confidence: 99%

Temporal Lobe Atrophy and White Matter Lesions are Related to Major Depression over 5 years in the Elderly

Olesen

Gustafson

Simoni

et al. 2010

Neuropsychopharmacol

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“…The scale steps are as follows: 0 = memory as usual, 2 = occasional increased lapses of memory, 4 = reports of socially inconvenient or disturbing loss of memory, 6 = complaints of complete inability to remember. 25 A physician, an ECT nurse, or other professional who was involved in administering the ECT treatment recorded the score based on the patients' subjective report. Subjective memory worsening was operationally defined as a worsening of at least 2 points (eg, from 2 to 4) on the item score from within 1 week before to within 1 week after treatment.…”

Section: Outcomementioning

confidence: 99%

“…25 The CPRS compromises 65 items and was developed during the 1970s for evaluation of psychiatric treatment effects. It has high reliability 26 and can be used in full or as an "item pool," for example, the MontgomeryÅsberg Depression Rating Scale (MADRS), which consists of 10 items from the CPRS.…”

Section: Outcomementioning

confidence: 99%

Subjective Memory Immediately Following Electroconvulsive Therapy

Brus¹,

Nordanskog²,

Båve³

et al. 2017

J ECT

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OBJECTIVES The aims of the present study were to describe the short-term rate of subjective memory worsening (SMW) and identify factors of importance for SMW in a large clinical sample treated for depression with electroconvulsive therapy (ECT). METHODS This register-based study included 1212 patients from the Swedish National Quality Register for ECT. Subjective memory worsening was defined as a 2-point worsening on the memory item of the Comprehensive Psychopathological Rating Scale from before to within 1 week after treatment. Associations between patient characteristics and treatment factors were examined using logistic regression. RESULTS Subjective memory worsening was experienced in 26%. It was more common in women than in men (31% vs 18%; P < 0.001) and more common in patients aged 18 to 39 years than in patients 65 years or older (32% vs 22%; P = 0.008). Patients with less subjective memory disturbances before ECT had a greater risk of SMW. Patients in remission after ECT had a lower risk of SMW. A brief pulse width stimulus gave higher risk of SMW compared with ultrabrief pulse (odds ratio, 1.61; 95% confidence interval, 1.05-2.47). CONCLUSIONS Subjective memory worsening is reported by a minority of patients. However, young women are at risk of experiencing SMW. Ultrabrief pulse width stimulus could be considered for patients treated with unilateral electrode placement who experience SMW. Each patient should be monitored with regard to symptoms and adverse effects, and treatment should be adjusted on an individual basis to maximize the clinical effect and with efforts to minimize the cognitive adverse effects.This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

Funding agencies: Swedish Research Council [523-2013-2982]; Swedish Foundation for Strategic Research

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“…Smoking intensity parameters included pack-years and Fagerstrom test of nicotine dependence score. The baseline measurement of depression and anxiety symptoms on the second day of admission were based on the Comprehensive Psychopathological Rating Scale (CPRS) (Asberg et al, 1978). Withdrawal intensity was evaluated using the Clinical Institute Withdrawal Assessment-Alcohol revised (CIWAAr) Scale approximately every 2-4 h while awake for the first 3-5 days after admission.…”

Section: Human Association Studymentioning

confidence: 99%

FKBP5 Moderates Alcohol Withdrawal Severity: Human Genetic Association and Functional Validation in Knockout Mice

Huang

Schwandt

Chester

et al. 2014

Neuropsychopharmacol

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Alcohol withdrawal is associated with hypothalamic-pituitary-adrenal (HPA) axis dysfunction. The FKBP5 gene codes for a cochaperone, FK506-binding protein 5, that exerts negative feedback on HPA axis function. This study aimed to examine the effects of single-nucleotide polymorphisms (SNPs) of the FKBP5 gene in humans and the effect of Fkbp5 gene deletion in mice on alcohol withdrawal severity. We genotyped six FKBP5 SNPs (rs3800373, rs9296158, rs3777747, rs9380524, rs1360780, and rs9470080) in 399 alcohol-dependent inpatients with alcohol consumption 48 h before admission and recorded scores from the Clinical Institute Withdrawal Assessment-Alcohol revised (CIWA-Ar). Fkbp5 gene knockout (KO) and wild-type (WT) mice were assessed for alcohol withdrawal using handling-induced convulsions (HICs) following both acute and chronic alcohol exposure. We found the minor alleles of rs3800373 (G), rs9296158 (A), rs1360780 (T), and rs9470080 (T) were significantly associated with lower CIWA-Ar scores whereas the minor alleles of rs3777747 (G) and rs9380524 (A) were associated with higher scores. The haplotype-based analyses also showed an association with alcohol withdrawal severity. Fkbp5 KO mice showed significantly greater HICs during withdrawal from chronic alcohol exposure compared with WT controls. This study is the first to show a genetic effect of FKBP5 on the severity of alcohol withdrawal syndrome. In mice, the absence of the Fkbp5 gene enhances sensitivity to alcohol withdrawal. We suggest that FKBP5 variants may trigger different adaptive changes in HPA axis regulation during alcohol withdrawal with concomitant effects on withdrawal severity.

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A Comprehensive Psychopathological Rating Scale

Cited by 1,170 publications

References 0 publications

Temporal Lobe Atrophy and White Matter Lesions are Related to Major Depression over 5 years in the Elderly

Temporal Lobe Atrophy and White Matter Lesions are Related to Major Depression over 5 years in the Elderly

Subjective Memory Immediately Following Electroconvulsive Therapy

FKBP5 Moderates Alcohol Withdrawal Severity: Human Genetic Association and Functional Validation in Knockout Mice

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