2022
DOI: 10.3390/molecules27082389
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A Comprehensive Overview of the Developments of Cdc25 Phosphatase Inhibitors

Abstract: Cdc25 phosphatases have been considered promising targets for anticancer development due to the correlation of their overexpression with a wide variety of cancers. In the last two decades, the interest in this subject has considerably increased and many publications have been launched concerning this issue. An overview is constructed based on data analysis of the results of the previous publications covering the years from 1992 to 2021. Thus, the main objective of the current review is to report the chemical s… Show more

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Cited by 7 publications
(3 citation statements)
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“…In this regard, there is plenty of research showing a correlation between Cdc25B signaling and tumorigenesis, and it would make perfect sense that cancer cells hijack this pathway in order to control mitotic entry. The connection between Cdc25B and cancer has led to an overwhelming effort trying to develop efficient Cdc25B inhibitors (77). These inhibitors however most of the time target the Cdc25B catalytic domain, and here, an exciting alternative might be finding small molecules that disrupt the Survivin-Cdc25B interaction.…”
Section: Discussionmentioning
confidence: 99%
“…In this regard, there is plenty of research showing a correlation between Cdc25B signaling and tumorigenesis, and it would make perfect sense that cancer cells hijack this pathway in order to control mitotic entry. The connection between Cdc25B and cancer has led to an overwhelming effort trying to develop efficient Cdc25B inhibitors (77). These inhibitors however most of the time target the Cdc25B catalytic domain, and here, an exciting alternative might be finding small molecules that disrupt the Survivin-Cdc25B interaction.…”
Section: Discussionmentioning
confidence: 99%
“…In this regard, there is plenty of research showing a correlation between Cdc25B signaling and tumorigenesis, and it would make perfect sense that cancer cells hijack this pathway in order to control mitotic entry. The connection between Cdc25B and cancer has led to an overwhelming effort trying to develop efficient Cdc25B inhibitors (75). These inhibitors however most of the time target the Cdc25B catalytic domain, and here, an exciting alternative might be finding small molecules that disrupt the Survivin-Cdc25B interaction.…”
Section: Future Strategies Regarding Cancer Treatment Arising From Th...mentioning
confidence: 99%
“…Early studies on CDC25A and B defined them as oncogenes 44 , with changes to CDC25 expression observed in a variety of cancers (reviewed in 36, 45, 46 ). Given their roles in regulating the cell cycle and response to checkpoint pathway signalling, small molecule inhibitors that target the active site have been reported (reviewed in 47 ), and alternative allosteric approaches targeting CDC25-protein interactions have been considered 48 . However, there remains a lack of structural information on the binding of CDC25 proteins with their CDK-cyclin substrates, which likely hinders the development of CDC25 inhibitors and CDC25-targetting anticancer strategies.…”
Section: Introductionmentioning
confidence: 99%