A comprehensive overview of radioguided surgery using gamma detection probe technology

Povoski, Stephen P.; Neff, Ryan; Mojzisik, Cathy; O’Malley, David M.; Hinkle, George H.; Hall, Nathan C.; Murrey, Douglas A.; Knopp, Michael V.; Martin, Edward W.

doi:10.1186/1477-7819-7-11

Cited by 213 publications

(177 citation statements)

References 639 publications

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“…The origins of intraoperative imaging trace back nearly seven decades, where Geiger-Müller detection of 32 Pphosphate uptake was used for the radio-guided localization of brain lesions 195,196 . Today, radio-guided methods remain a viable clinical tool for both resection (for example, radioimmuno-guided surgery in colorectal 197 and brain cancer 198 ) and biopsy (for example, 99m Tc colloids for SLN biopsy in breast cancer) 196,198,199 .…”

Section: Intraoperative Imagingmentioning

confidence: 99%

“…Today, radio-guided methods remain a viable clinical tool for both resection (for example, radioimmuno-guided surgery in colorectal 197 and brain cancer 198 ) and biopsy (for example, 99m Tc colloids for SLN biopsy in breast cancer) 196,198,199 . An underlying strength of radionuclide imaging is that pre-surgical imaging and radio-guided surgery can be conducted with the same probes.…”

Section: Intraoperative Imagingmentioning

confidence: 99%

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Multiplexed imaging for diagnosis and therapy

et al. 2017

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Complex molecular and metabolic phenotypes depict cancers as a constellation of different diseases with common themes. Precision imaging of such phenotypes requires flexible and tuneable modalities capable of identifying phenotypic fingerprints by using a restricted number of parameters whilst ensuring sensitivity to dynamic biological regulation. Common phenotypes can be detected by in vivo imaging technologies, and effectively define the emerging standards for disease classification and patient stratification in radiology. However, for the imaging data to accurately represent a complex fingerprint, the individual imaging parameters need to be measured and analysed in relation to their wider spatial and molecular context. In this respect, targeted palettes of molecular imaging probes facilitate the detection of heterogeneity in oncogene-driven alterations and their response to treatment, and lead to the expansion of rational-design elements for the combination of imaging experiments. In this Review, we evaluate criteria for conducting multiplexed imaging, and discuss its opportunities for improving patient diagnosis and the monitoring of therapy.

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Section: Intraoperative Imagingmentioning

confidence: 99%

Section: Intraoperative Imagingmentioning

confidence: 99%

Multiplexed imaging for diagnosis and therapy

et al. 2017

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“…35 The probe translates the detected gamma photons into an acoustic signal and continuous digital count display. Various laparoscopic gamma-ray detection probes are available with various energy windows: 0°, 45°or 90°lateral.…”

Section: Gamma-ray Detection Probementioning

confidence: 99%

Advances in sentinel node dissection in prostate cancer from a technical perspective

et al. 2015

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Abbreviations & Acronyms ePLND = extended pelvic lymph node dissection FN = false negative ICG = indocyanine green LN = lymph node MRI = magnetic resonance imaging NIR = near-infrared NR = not reported PCa = prostate cancer PET = positron emission tomography PLND = pelvic lymph node dissection SN = sentinel node SPECT-CT = single-photon emission computed tomography combined with computed tomography TRUS = transrectal ultrasound Abstract: The most important feature of sentinel node biopsy for prostate cancer procedure is that staging can be improved. Sentinel nodes might be found outside the extended pelvic lymph node dissection template what renders the sentinel node additive of extended pelvic lymph node dissection. At the same time, staging within the template can be further refined. We reviewed the literature regarding the sentinel node biopsy procedure for prostate cancer. PubMed and Embase were searched for all Englishlanguage publications from January 1999 to September 2014 by using the keywords as "prostate cancer" and "sentinel lymph node" plus "biopsy" "dissection" and/or "procedure." The present review discusses step-by-step sentinel node biopsy for prostate cancer. Topics of discussion are: (i) preoperative sentinel node mapping (tracers and imaging); (ii) intraoperative sentinel node identification (surgical procedure and outcome); and (iii) novelties to improve sentinel node identification (pre-and intraoperative approaches). Conventional sentinel node mapping is carried out after the injection of a 99m Tc-based tracer and subsequent preoperative imaging; for example, lymphoscintigraphy and singlephoton emission computed tomography/computed tomography. This approach allowed the detection of sentinel nodes outside the extended lymph node dissection template in 3.6-36% of men with intermediate-and high-risk prostate cancer. Hereby, an overall false negative rate of sentinel nodes was reported between 0% and 24.4%. To further refine the intraoperative sampling procedure, novel imaging methods such as fluorescence imaging have been introduced. Prospective randomized comparison studies are required to confirm the added benefit of sentinel template directed nodal dissection. A proper and obtainable end-point of such a study could be the number of removed positive nodes for carrying out nodal dissection with or without sentinel template directed dissection. Similarly, the clinical impact of novel imaging technologies requires further investigation.

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“…Today, hand-held gamma detection probes are commonplace and are utilized widely for the intraoperative detection of various radiopharmaceuticals during cancer surgery [1]. The basic technical principles behind the functionality of these devices [1][2][3][4][5][6], as well as their many clinical applications [1], have been well characterized previously.…”

mentioning

confidence: 99%