A comprehensive assessment of Yarrowia lipolytica and its interactions with metals: Current updates and future prospective

Kolhe, Nilesh; Damle, Eeshan; Pradhan, Aditya; Zinjarde, Smita

doi:10.1016/j.biotechadv.2022.107967

Cited by 12 publications

(5 citation statements)

References 149 publications

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“…However, fungal extracts treated with HAuCl 4 salt exhibit a prominent absorption peak at 545 nm, strongly suggesting the successful synthesis of AuNPs (Figure 1B). Similar results have been seen in earlier reports, where it has been demonstrated that the absorbance of gold NPs was in the range of 540-570 nm [43][44][45].…”

Section: Spectrophotometric Analysissupporting

confidence: 92%

Biological Synthesis, Characterization, and Therapeutic Potential of S. commune-Mediated Gold Nanoparticles

Alqurashi,

Almalki,

Ibrahim

et al. 2023

Biomolecules

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Green-synthesized gold nanoparticles demonstrate several therapeutic benefits due to their safety, non-toxicity, accessibility, and ecological acceptance. In our study, gold nanoparticles (AuNPs) were created using an extracellular extract from the fungus Schizophyllum commune (S. commune). The reaction color was observed to be a reddish pink after a 24 h reaction, demonstrating the synthesis of the nanoparticles. The myco-produced nanoparticles were investigated using transmission electron microscopy (TEM), dynamic light scattering (DLS), and UV–visible spectroscopy. The TEM pictures depicted sphere-like shapes with sizes ranging from 60 and 120 nm, with an average diameter of 90 nm, which is in agreement with the DLS results. Furthermore, the efficiency of the AuNPs’ antifungal and cytotoxic properties, as well as their production of intracellular ROS, was evaluated. Our findings showed that the AuNPs have strong antifungal effects against Trichoderma sp. and Aspergillus flavus at increasing doses. Additionally, the AuNPs established a dose-dependent activity against human alveolar basal epithelial cells with adenocarcinoma (A549), demonstrating the potency of synthesized AuNPs as a cytotoxic agent. After 4 h of incubation with AuNPs, a significant increase in intracellular ROS was observed in cancer cells. Therefore, these metallic AuNPs produced by fungus (S. commune) can be used as an effective antifungal, anticancer, and non-toxic immunomodulatory delivery agent.

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Section: Spectrophotometric Analysissupporting

confidence: 92%

Biological Synthesis, Characterization, and Therapeutic Potential of S. commune-Mediated Gold Nanoparticles

Alqurashi,

Almalki,

Ibrahim

et al. 2023

Biomolecules

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“…The morphology of the domesticated strains changed from large and round colonies to smaller ones. Kolhe obtained an analogous result that the dimorphic behavior of Y. lipolytica from yeast to mycelial forms was altered in response to metal stress [28]. In addition, biofilm formation is another way to resist metal ion stress.…”

Section: Influence Of Copper Ion Stressmentioning

confidence: 90%

“…The significant increase in the removal rate of copper ions indicates that Y. lipolytica has played an important role in promoting the removal of copper ions. Phosphatases, metallothionein, and organic acids are reported to play essential roles in overcoming copper ion stress in Y. lipolytica [28]. Y. lipolytica exhibited higher phosphatase levels in a copper-supplemented medium, which increased with metal ion concentrations [36].…”

Section: Influence Of Copper Ion Stressmentioning

confidence: 98%

“…This finding suggests that metal removal is mainly due to cell secretions (organic acids) rather than the cells' adsorption. The interactions of strains and Cu elements include extracellular complexation through organic acids, precipitation, and adsorption onto the cell wall [28]. The Y. lipolytica strain treatment led to extensive solubilization of Cu with increasing cultivation days under the same strains' concentrations.…”

Section: Influence Of Initial Strain Concentrationsmentioning

confidence: 99%

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A Comparative Study on Heavy Metal Removal from CCA-Treated Wood Waste by Yarrowia lipolytica: Effects of Metal Stress

Xing

Magdouli

Zhang

et al. 2023

JoF

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Bioremediation is an effective way to remove heavy metals from pollutants. This study investigated the effects of Yarrowia lipolytica (Y. lipolytica) on the bioremediation of chromated copper arsenate (CCA)-treated wood wastes. Copper ions stressed the yeast strains to improve their bioremediation efficiency. A comparison of changes in morphology, chemical composition, and metal content of CCA wood before and after bioremediation was conducted. The amount of arsenic (As), chromium (Cr), and copper (Cu) was quantified by microwave plasma atomic emission spectrometer. The results showed that yeast strains remained on the surface of CCA-treated wood after bioremediation. The morphologies of the strains changed from net to spherical because of the Cu2+ stress. Fourier-transform infrared spectroscopy showed that carboxylic acid groups of wood were released after removing heavy metals. A large amount of oxalic acid was observed when the optical density (OD600nm) was 0.05 on the 21st day. Meanwhile, the highest removal rate of Cu, As, and Cr was 82.8%, 68.3%, and 43.1%, respectively. Furthermore, the Cu removal from CCA-treated wood increased by about 20% after Cu2+ stress. This study showed that it is feasible to remove heavy metals from CCA-treated wood by Y. lipolytica without destroying the wood structure, especially by copper-induced Y. lipolytica.

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“…Y. lipolytica, although it has multiple biotechnological applications, its cell size and morphology require a thorough investigation to select suitable supports for immobilization and modulation [83]. In this sense, superficial adaptations, with activations and functionalizations of metallic supports and those based on silica, cellulose, and chitosan, have been showing promising results in the mutation of Y. lipolytica [260,261].…”

Section: Modulation Of Lipases From Y Lipolytica Properties Via Immob...mentioning

confidence: 99%

Lipase from Yarrowia lipolytica: Prospects as an Industrial Biocatalyst for Biotechnological Applications

et al. 2023

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This paper aims to present the advances related to the biotechnological application of lipases Y. lipolytica, presenting their properties and more efficient ways to use them in different industrial applications. Waste treatment and bioremediation highlight recent studies and advances and the interest in large-scale applications in the food sector and biofuel production. The USA and China, two major world powers in industy, are of utmost importance in the search for the improvement in the development and properties of a controlled system for the large-scale production of a significant number of applications of lipase from Y. lipolytica.

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A comprehensive assessment of Yarrowia lipolytica and its interactions with metals: Current updates and future prospective

Cited by 12 publications

References 149 publications

Biological Synthesis, Characterization, and Therapeutic Potential of S. commune-Mediated Gold Nanoparticles

Biological Synthesis, Characterization, and Therapeutic Potential of S. commune-Mediated Gold Nanoparticles

A Comparative Study on Heavy Metal Removal from CCA-Treated Wood Waste by Yarrowia lipolytica: Effects of Metal Stress

Lipase from Yarrowia lipolytica: Prospects as an Industrial Biocatalyst for Biotechnological Applications

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