2023
DOI: 10.21203/rs.3.rs-3520814/v1
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A complete mass spectrometry-based immunopeptidomics pipeline for neoantigen identification and validation

Ming Li,
Ngoc Hieu Tran,
Chao Peng
et al.

Abstract: Here we proposed DeepImmu, a complete pipeline for neoantigen identification and validation that was based solely on mass spectrometry (MS) immunopeptidomics. In particular, a new enrichment kit was developed for HLA peptide purification from a small amount of biopsied tissue as low as 18mg. To identify candidate neoantigens from such a small amount of sample, we built DeepNovo Peptidome, a highly sensitive de novo sequencing-based workflow for HLA peptide identification. Furthermore, we developed DeepSelf, a … Show more

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