A Comparison of Wound Healing in Sutured and Unsutured Corneal Wounds

<p>Factors predicting change in corneal astigmatism following suture removal in post-penetrating keratoplasty patients</p>

“……”

<p>Factors predicting change in corneal astigmatism following suture removal in post-penetrating keratoplasty patients</p>

“……”

Quantification of Collagen Ultrastructure after Penetrating Keratoplasty – Implications for Corneal Biomechanics

“…The current results align well with this view, demonstrating extensive long-term abnormalities in collagen fibril orientation and spatial organisation around the entire graft margin following PK. Firstly, we noted that collagen orientation was predominantly tangential to the wound edge, consistent with findings reported in previous long-term PK follow-ups [3], [9]. It is possible that this observation could be partly a legacy of a mechanical distortion of existing collagen during trephination [2], likely augmented by new collagen secreted by infiltrating activated host keratocytes aligning with the donor button edge via contact guidance [30].…”

“…To what extent, if any, collagen structural changes contribute to the mechanisms underlying graft failure remains to be established. However, there is a large body of evidence to suggest that normal stromal architecture may never be fully recovered in full-thickness graft wounds [3], [9], [11], [12], [13], [14], [15], [28], [29]. The current results align well with this view, demonstrating extensive long-term abnormalities in collagen fibril orientation and spatial organisation around the entire graft margin following PK.…”

Correction: Quantification of Collagen Ultrastructure after Penetrating Keratoplasty – Implications for Corneal Biomechanics

“…The current results align well with this view, demonstrating extensive long-term abnormalities in collagen fibril orientation and spatial organisation around the entire graft margin following PK. Firstly, we noted that collagen orientation was predominantly tangential to the wound edge, consistent with findings reported in previous long-term PK followups [3,9]. It is possible that this observation could be partly a legacy of a mechanical distortion of existing collagen during trephination [2], likely augmented by new collagen secreted by infiltrating activated host keratocytes aligning with the donor button edge via contact guidance [30].…”

“…To what extent, if any, collagen structural changes contribute to the mechanisms underlying graft failure remains to be established. However, there is a large body of evidence to suggest that normal stromal architecture may never be fully recovered in full-thickness graft wounds [3,9,11,12,13,14,15,28,29]. The current results align well with this view, demonstrating extensive long-term abnormalities in collagen fibril orientation and spatial organisation around the entire graft margin following PK.…”

<p>Factors predicting change in corneal astigmatism following suture removal in post-penetrating keratoplasty patients</p>

“……”

Quantification of Collagen Ultrastructure after Penetrating Keratoplasty – Implications for Corneal Biomechanics

“…The current results align well with this view, demonstrating extensive long-term abnormalities in collagen fibril orientation and spatial organisation around the entire graft margin following PK. Firstly, we noted that collagen orientation was predominantly tangential to the wound edge, consistent with findings reported in previous long-term PK follow-ups [3], [9]. It is possible that this observation could be partly a legacy of a mechanical distortion of existing collagen during trephination [2], likely augmented by new collagen secreted by infiltrating activated host keratocytes aligning with the donor button edge via contact guidance [30].…”

“…To what extent, if any, collagen structural changes contribute to the mechanisms underlying graft failure remains to be established. However, there is a large body of evidence to suggest that normal stromal architecture may never be fully recovered in full-thickness graft wounds [3], [9], [11], [12], [13], [14], [15], [28], [29]. The current results align well with this view, demonstrating extensive long-term abnormalities in collagen fibril orientation and spatial organisation around the entire graft margin following PK.…”

Correction: Quantification of Collagen Ultrastructure after Penetrating Keratoplasty – Implications for Corneal Biomechanics

“…The current results align well with this view, demonstrating extensive long-term abnormalities in collagen fibril orientation and spatial organisation around the entire graft margin following PK. Firstly, we noted that collagen orientation was predominantly tangential to the wound edge, consistent with findings reported in previous long-term PK followups [3,9]. It is possible that this observation could be partly a legacy of a mechanical distortion of existing collagen during trephination [2], likely augmented by new collagen secreted by infiltrating activated host keratocytes aligning with the donor button edge via contact guidance [30].…”

“…To what extent, if any, collagen structural changes contribute to the mechanisms underlying graft failure remains to be established. However, there is a large body of evidence to suggest that normal stromal architecture may never be fully recovered in full-thickness graft wounds [3,9,11,12,13,14,15,28,29]. The current results align well with this view, demonstrating extensive long-term abnormalities in collagen fibril orientation and spatial organisation around the entire graft margin following PK.…”

<p>Factors predicting change in corneal astigmatism following suture removal in post-penetrating keratoplasty patients</p>

“……”

Quantification of Collagen Ultrastructure after Penetrating Keratoplasty – Implications for Corneal Biomechanics

“…The current results align well with this view, demonstrating extensive long-term abnormalities in collagen fibril orientation and spatial organisation around the entire graft margin following PK. Firstly, we noted that collagen orientation was predominantly tangential to the wound edge, consistent with findings reported in previous long-term PK follow-ups [3], [9]. It is possible that this observation could be partly a legacy of a mechanical distortion of existing collagen during trephination [2], likely augmented by new collagen secreted by infiltrating activated host keratocytes aligning with the donor button edge via contact guidance [30].…”

“…To what extent, if any, collagen structural changes contribute to the mechanisms underlying graft failure remains to be established. However, there is a large body of evidence to suggest that normal stromal architecture may never be fully recovered in full-thickness graft wounds [3], [9], [11], [12], [13], [14], [15], [28], [29]. The current results align well with this view, demonstrating extensive long-term abnormalities in collagen fibril orientation and spatial organisation around the entire graft margin following PK.…”

Correction: Quantification of Collagen Ultrastructure after Penetrating Keratoplasty – Implications for Corneal Biomechanics

“…The current results align well with this view, demonstrating extensive long-term abnormalities in collagen fibril orientation and spatial organisation around the entire graft margin following PK. Firstly, we noted that collagen orientation was predominantly tangential to the wound edge, consistent with findings reported in previous long-term PK followups [3,9]. It is possible that this observation could be partly a legacy of a mechanical distortion of existing collagen during trephination [2], likely augmented by new collagen secreted by infiltrating activated host keratocytes aligning with the donor button edge via contact guidance [30].…”

“…To what extent, if any, collagen structural changes contribute to the mechanisms underlying graft failure remains to be established. However, there is a large body of evidence to suggest that normal stromal architecture may never be fully recovered in full-thickness graft wounds [3,9,11,12,13,14,15,28,29]. The current results align well with this view, demonstrating extensive long-term abnormalities in collagen fibril orientation and spatial organisation around the entire graft margin following PK.…”