A comparison of type O foot and mouth disease virus field isolates from northern Thailand

Blacksell, Stuart D.; Gleeson, Laurence J.; Chamnanpood, Ch.; Nakarungkul, N.; Megkamol, Ch.

doi:10.20506/rst.11.3.621

Cited by 3 publications

(2 citation statements)

References 7 publications

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“…To predict how well a vaccine will protect against a challenge virus of another strain within the same serotype requires vaccine-matching studies, involving in vivo cross-protection studies and harmonisation of in vitro r -value determinations between vaccine strains and field isolates [34]. There is an urgent need to prove the utility of contemporary vaccine strains in controlling the spread of field viruses causing FMD outbreaks, as the majority of published vaccine-matching studies from SEA are now only of historical value being from the 1980s and 1990s [21, 37, 38, 72].…”

Section: Discussionmentioning

confidence: 99%

“…A limited number of published studies have examined the efficacy of locally produced and imported vaccines against viruses causing disease in SEA. Studies in the late 1970s and 1980s determined that serotype A and Asia 1 viruses from Thailand were found to be divergent requiring the development of new vaccines [21, 35, 36], whilst serotype O isolates were found to be largely homologous [37, 38] and vaccines of the time provided good protection. However, the evolution and spread of O/ME-SA/Ind-2001 lineage viruses to SEA has raised question regarding vaccine efficacy of the conventional complement of vaccine strains mainly O/3039 and O 1 /Manisa.…”

Section: Risk Factors That Influence the Spread Of Fmd In Seamentioning

confidence: 99%

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A history of FMD research and control programmes in Southeast Asia: lessons from the past informing the future

et al. 2019

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Foot and mouth disease (FMD) is a major animal health problem within Southeast Asia (SEA). Although Indonesia and more recently the Philippines have achieved freedom from FMD, the disease remains endemic on continental SEA. Control of FMD within SEA would increase access to markets in more developed economies and reduce lost productivity in smallholder and emerging commercial farmer settings. However, despite many years of vaccination by individual countries, numerous factors have prevented the successful control of FMD within the region, including unregulated ‘informal’ transboundary movement of livestock and their products, difficulties implementing vaccination programmes, emergence of new virus topotypes and lineages, low-level technical capacity and biosecurity at national levels, limited farmer knowledge on FMD disease recognition, failure of timely outbreak reporting and response, and limitations in national and international FMD control programmes. This paper examines the published research of FMD in the SEA region, reviewing the history, virology, epidemiology and control programmes and identifies future opportunities for FMD research aimed at the eventual eradication of FMD from the region.

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Section: Discussionmentioning

confidence: 99%

Section: Risk Factors That Influence the Spread Of Fmd In Seamentioning

confidence: 99%

A history of FMD research and control programmes in Southeast Asia: lessons from the past informing the future

et al. 2019

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A modified liquid phase (LP) blocking ELISA used to assess type O foot-and-mouth disease virus antigenic variation in Thailand

Lunt

Linchongsubongkoch²,

Gleeson

1994

Veterinary Microbiology

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Establishment of a typing enzyme-linked immunosorbent assay for foot and mouth disease antigen, using reagents against viruses endemic in Thailand

Blacksell

Lunt²,

Chamnanpood³

et al. 1994

Rev. Sci. Tech. OIE

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Antisera were produced at a central laboratory in Thailand against the endemic serotypes (O, A and Asia 1) of foot and mouth disease (FMD) virus. At a regional veterinary laboratory, these antisera were used in an indirect sandwich enzyme-linked immunosorbent assay (ELISA) for the detection and serotyping of FMD virus (FMDV) antigen. ELISA readings of <0.10 optical density (OD) units were considered negative. This was verified using fifty tissue samples which were known to be negative for FMDV. The highest mean sample value for three different dilutions was 0.02 OD units. Of a total of 93 samples submitted for antigen typing, 80 (86%) tested positive by ELISA and 13 (14%) were negative. No FMDV was detected in ELISA-negative samples following attempted tissue-culture virus isolation.

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A comparison of type O foot and mouth disease virus field isolates from northern Thailand

Cited by 3 publications

References 7 publications

A history of FMD research and control programmes in Southeast Asia: lessons from the past informing the future

A history of FMD research and control programmes in Southeast Asia: lessons from the past informing the future

A modified liquid phase (LP) blocking ELISA used to assess type O foot-and-mouth disease virus antigenic variation in Thailand

Establishment of a typing enzyme-linked immunosorbent assay for foot and mouth disease antigen, using reagents against viruses endemic in Thailand

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