The trackability is an essential property for determining the handling characteristics of coronary stent systems. It depends on the friction properties and flexibility of the stent system, the constitution of the vessel, but also on the properties of the guide wire used for the intervention. The influence of five commercially available coronary workhorse guide wires of different manufactures (Abbott, BIO-TRONIK, Boston Scientific, Medtronic, Terumo) on trackability of two different stent systems was tested. Proximal shaft force was measured while moving a stent system over the guide wire to be tested into an in vitro vessel model. The trackability of the stent systems was best with BIOTRONIK Galeo Hydro and worst with Boston Scientific Luge™. The trackability of stent systems does not only depend on the properties of the stent system itself, but also on the guide wire used. The trackability properties could be improved by using an appropriate combination of stent system and guide wire.