A comparison of the efficacy and safety of Jessner's solution and 35% trichloroacetic acid vs 5% fluorouracil in the treatment of widespread facial actinic keratoses

Facial Resurfacing for Nonmelanoma Skin Cancer Prophylaxis

“…Our results with trichloroacetic acid peel are comparable with those of a split-face study of 15 patients by Lawrence et al 18 comparing fluorouracil with a chemical peel containing Jessner solution and 35% trichloroacetic acid. In this study, both fluorouracil and the chemical peel resulted in an approximately 75% reduction of AKs.…”

“…33 Trichloroacetic acid was noted to be as effective as fluorouracil in preventing the recurrence of AKs for at least 1 year. 18 Lowconcentration (Յ30%) trichloroacetic acid peel has less morbidity than topical fluorouracil, and in the present study and as noted by Lawrence et al, 18 patients preferred chemical resurfacing to fluorouracil use because of its convenient single application, minimal adverse effects, and rapid healing time.…”

Facial Resurfacing for Nonmelanoma Skin Cancer Prophylaxis

“…Our results with trichloroacetic acid peel are comparable with those of a split-face study of 15 patients by Lawrence et al 18 comparing fluorouracil with a chemical peel containing Jessner solution and 35% trichloroacetic acid. In this study, both fluorouracil and the chemical peel resulted in an approximately 75% reduction of AKs.…”

“…33 Trichloroacetic acid was noted to be as effective as fluorouracil in preventing the recurrence of AKs for at least 1 year. 18 Lowconcentration (Յ30%) trichloroacetic acid peel has less morbidity than topical fluorouracil, and in the present study and as noted by Lawrence et al, 18 patients preferred chemical resurfacing to fluorouracil use because of its convenient single application, minimal adverse effects, and rapid healing time.…”

Ingenol Mebutate: A Promising Treatment for Actinic Keratoses and Nonmelanoma Skin Cancers

“…38,,,,,,,,,,,,–51 After a 12-month follow-up, 53.9% (head) and 56.0% (nonhead) of the participants completely cured with ingenol mebutate treatment experienced recurrence. 52 Similar recurrence rates at the 1-year follow-up were obtained with 2.5% imiquimod (51.4–66.7%), 53 3.75% imiquimod (41.7–54.8%), 53 0.5% 5-fluorouracil (58.7%), 54 and 5% 5-fluorouracil (14–65.2%), 55,–57 but lower recurrence rates were seen for 5% imiquimod (10–42.6%). 50,57,–59 A long-term study with 3% diclofenac in 2.5% hyaluronic acid reported the number of participants with complete clearance at the 1-year assessment but did not report the recurrence rate.…”

Chemical peelings for the treatment of actinic keratosis: a systematic review and meta‐analysis

“…TCA 35% and Jessner's solution showed significantly lower participant complete clearance compared to 5‐FU 5% cream (RR 0.36, 95% CI: 0.14–0.90, two studies, I 2 = 0%, P = 0.03; Fig. 2a) 16,20 . 5‐FU in combination with glycolic acid 70% was not significantly more effective in achieving a participant complete clearance than glycolic acid 70% alone 21 (Table 2).…”

“…2b). TCA 35% and Jessner's solution achieved lower clearance in comparison to 5‐FU 5% (RR 0.92, 95% CI: 0.85–0.99, one study, P = 0.03) 20 . The combination of 5‐FU 5% and glycolic acid 70% showed a significantly higher lesion complete clearance rate than glycolic acid 70% monotherapy (RR 5.87, 95% CI: 4.39–7.85, one study, P < 0.001) 21 .…”

Facial Resurfacing for Nonmelanoma Skin Cancer Prophylaxis

“…Our results with trichloroacetic acid peel are comparable with those of a split-face study of 15 patients by Lawrence et al 18 comparing fluorouracil with a chemical peel containing Jessner solution and 35% trichloroacetic acid. In this study, both fluorouracil and the chemical peel resulted in an approximately 75% reduction of AKs.…”

“…33 Trichloroacetic acid was noted to be as effective as fluorouracil in preventing the recurrence of AKs for at least 1 year. 18 Lowconcentration (Յ30%) trichloroacetic acid peel has less morbidity than topical fluorouracil, and in the present study and as noted by Lawrence et al, 18 patients preferred chemical resurfacing to fluorouracil use because of its convenient single application, minimal adverse effects, and rapid healing time.…”

Ingenol Mebutate: A Promising Treatment for Actinic Keratoses and Nonmelanoma Skin Cancers

“…38,,,,,,,,,,,,–51 After a 12-month follow-up, 53.9% (head) and 56.0% (nonhead) of the participants completely cured with ingenol mebutate treatment experienced recurrence. 52 Similar recurrence rates at the 1-year follow-up were obtained with 2.5% imiquimod (51.4–66.7%), 53 3.75% imiquimod (41.7–54.8%), 53 0.5% 5-fluorouracil (58.7%), 54 and 5% 5-fluorouracil (14–65.2%), 55,–57 but lower recurrence rates were seen for 5% imiquimod (10–42.6%). 50,57,–59 A long-term study with 3% diclofenac in 2.5% hyaluronic acid reported the number of participants with complete clearance at the 1-year assessment but did not report the recurrence rate.…”

Chemical peelings for the treatment of actinic keratosis: a systematic review and meta‐analysis

“…TCA 35% and Jessner's solution showed significantly lower participant complete clearance compared to 5‐FU 5% cream (RR 0.36, 95% CI: 0.14–0.90, two studies, I 2 = 0%, P = 0.03; Fig. 2a) 16,20 . 5‐FU in combination with glycolic acid 70% was not significantly more effective in achieving a participant complete clearance than glycolic acid 70% alone 21 (Table 2).…”

“…2b). TCA 35% and Jessner's solution achieved lower clearance in comparison to 5‐FU 5% (RR 0.92, 95% CI: 0.85–0.99, one study, P = 0.03) 20 . The combination of 5‐FU 5% and glycolic acid 70% showed a significantly higher lesion complete clearance rate than glycolic acid 70% monotherapy (RR 5.87, 95% CI: 4.39–7.85, one study, P < 0.001) 21 .…”

Facial Resurfacing for Nonmelanoma Skin Cancer Prophylaxis

“…Our results with trichloroacetic acid peel are comparable with those of a split-face study of 15 patients by Lawrence et al 18 comparing fluorouracil with a chemical peel containing Jessner solution and 35% trichloroacetic acid. In this study, both fluorouracil and the chemical peel resulted in an approximately 75% reduction of AKs.…”

“…33 Trichloroacetic acid was noted to be as effective as fluorouracil in preventing the recurrence of AKs for at least 1 year. 18 Lowconcentration (Յ30%) trichloroacetic acid peel has less morbidity than topical fluorouracil, and in the present study and as noted by Lawrence et al, 18 patients preferred chemical resurfacing to fluorouracil use because of its convenient single application, minimal adverse effects, and rapid healing time.…”

Ingenol Mebutate: A Promising Treatment for Actinic Keratoses and Nonmelanoma Skin Cancers

“…38,,,,,,,,,,,,–51 After a 12-month follow-up, 53.9% (head) and 56.0% (nonhead) of the participants completely cured with ingenol mebutate treatment experienced recurrence. 52 Similar recurrence rates at the 1-year follow-up were obtained with 2.5% imiquimod (51.4–66.7%), 53 3.75% imiquimod (41.7–54.8%), 53 0.5% 5-fluorouracil (58.7%), 54 and 5% 5-fluorouracil (14–65.2%), 55,–57 but lower recurrence rates were seen for 5% imiquimod (10–42.6%). 50,57,–59 A long-term study with 3% diclofenac in 2.5% hyaluronic acid reported the number of participants with complete clearance at the 1-year assessment but did not report the recurrence rate.…”

Chemical peelings for the treatment of actinic keratosis: a systematic review and meta‐analysis

“…TCA 35% and Jessner's solution showed significantly lower participant complete clearance compared to 5‐FU 5% cream (RR 0.36, 95% CI: 0.14–0.90, two studies, I 2 = 0%, P = 0.03; Fig. 2a) 16,20 . 5‐FU in combination with glycolic acid 70% was not significantly more effective in achieving a participant complete clearance than glycolic acid 70% alone 21 (Table 2).…”

“…2b). TCA 35% and Jessner's solution achieved lower clearance in comparison to 5‐FU 5% (RR 0.92, 95% CI: 0.85–0.99, one study, P = 0.03) 20 . The combination of 5‐FU 5% and glycolic acid 70% showed a significantly higher lesion complete clearance rate than glycolic acid 70% monotherapy (RR 5.87, 95% CI: 4.39–7.85, one study, P < 0.001) 21 .…”