1994
DOI: 10.1001/archderm.130.3.319
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A comparison of the efficacy of topical tretinoin and low-dose oral isotretinoin in rosacea

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Cited by 41 publications
(48 citation statements)
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“…35 Oral isotretinoin in low doses has been reported to be effective in the control of rosacea that was otherwise resistant to treatment, but the ocular and cutaneous drying effects of this agent are poorly tolerated, and its potential for serious adverse effects (including teratogenic effects) contradicts its use in routine care. Topical tretinoin has been reported to be as effective as oral isotretinoin after 16 weeks of treatment 36 and may be helpful in the treatment of patients with papulopustular rosacea who also have oily skin. 37 Anecdotal reports have suggested that Cucumis sativus (cucumber), applied in a cooled yogurt paste, is helpful in reducing facial edema of rosacea that is otherwise resistant to treatment 38 and that facial massage involving rotatory movements of the fingers from the central to the peripheral face may improve papulopustular and edematous skin changes.…”
Section: Managementmentioning
confidence: 99%
“…35 Oral isotretinoin in low doses has been reported to be effective in the control of rosacea that was otherwise resistant to treatment, but the ocular and cutaneous drying effects of this agent are poorly tolerated, and its potential for serious adverse effects (including teratogenic effects) contradicts its use in routine care. Topical tretinoin has been reported to be as effective as oral isotretinoin after 16 weeks of treatment 36 and may be helpful in the treatment of patients with papulopustular rosacea who also have oily skin. 37 Anecdotal reports have suggested that Cucumis sativus (cucumber), applied in a cooled yogurt paste, is helpful in reducing facial edema of rosacea that is otherwise resistant to treatment 38 and that facial massage involving rotatory movements of the fingers from the central to the peripheral face may improve papulopustular and edematous skin changes.…”
Section: Managementmentioning
confidence: 99%
“…Isotretinoin in modest doses is used to shrink significant rhinophyma over several months of therapy before surgical reduction of the dose. The efficacy and safety of low-dose isotretinoin in the treatment of rosacea have been demonstrated in several clinical studies [84, 85, 86]. Isotretinoin at a dosage of 0.1–0.2 mg/kg body weight per day produces significant therapeutic effects in patients with papulopustular rosacea.…”
Section: Systemic Therapymentioning
confidence: 99%
“…At a later stage, drug therapy is often necessary. This includes systemic antibiotics such as tetracyclines, topical antibiotics such as erythromycin and clindamycin, antifungal agents such as metronidazole, azelaic acid and topical and systemic retinoid therapy [5]. Treatment with topical retinoic acid has been proven to be successful, but patients tended towards noncompliance due to skin irritation [1, 5].…”
Section: Discussionmentioning
confidence: 99%
“…This includes systemic antibiotics such as tetracyclines, topical antibiotics such as erythromycin and clindamycin, antifungal agents such as metronidazole, azelaic acid and topical and systemic retinoid therapy [5]. Treatment with topical retinoic acid has been proven to be successful, but patients tended towards noncompliance due to skin irritation [1, 5]. It is shown here that topical retinaldehyde alleviates the redness of rosacea, with fewer side effects and no exacerbation of the lesions, and is more acceptable to the patients.…”
Section: Discussionmentioning
confidence: 99%