A comparison of specific IgE and skin prick test results to common environmental allergens using the HYTEC™ 288

Knight, Vijaya; Wolf, Molly L.; Trikha, Anita; Curran‐Everett, Douglas; Hiserote, Melissa; Harbeck, Ronald J.

doi:10.1016/j.jim.2018.07.005

Cited by 8 publications

(10 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Atopy is thought to respond to many allergens, leading to CD4 + Th2 differentiation and overexpression of IgE, so we collected the results of IgE from all people who already have done SPT. Among 3450 IgE result, the patients with elevated IgE were 2413 with a percentage of 69.96%, which came in concordance with a study done in Colorado, in which Knight et al (16) reported good concordance between both SPT and IgE with an overall >70% agreement between methods. If an IgE test is carried out and has results beyond expectation when considering the history, SPT should be carried out to confirm the diagnosis of an allergy.…”

Section: Discussionsupporting

confidence: 86%

Skin Prick Test Results and Total IgE Levels of Asthma Patients in Zagazig University Hospital (2015-2019)

Salama¹,

Mahfouz²,

Sileem³

et al. 2022

The Egyptian Journal of Hospital Medicine

View full text Add to dashboard Cite

Background: Bronchial asthma is one of the relevant diseases of the respiratory tract, the asthma is one of the forms of respiratory allergy. The change in environment and aeroallergens are the main etiology of asthma. Allergy of asthma is thought to affect the bronchial region of the respiratory airway. Objective: The current study aimed to compare the total IgE elevation and skin prick test (SPT) positivity to evaluate the IgE and SPT ability to assess the asthmatic severity. Subjects and Methods: This retrospective case study was carried out on 3450 cases at the outpatient clinic and Chest Department at Zagazig University and did skin prick test and IgE in authorized centers were collected from 2015 -2019. The cases were already diagnosed asthmatic according to Global Initiative for Asthma (GINA) (9) guidelines and were divided according to severity into mild, moderate, and severe according to GINA guidelines. Results: IgE has been tested for different aeroallergens and has strong significant elevation with (P< 0.001) in Alternaria, cat hair, cotton, birch, and helminths aeroallergen. Most of the cases with elevated IgE had moderate asthma severity followed by mild severity cases then severe cases. Conclusion:Comparing the results of SPT and IgE, the SPT test is more accurate, reliable, and easy in detecting the aeroallergen sensitivity.

show abstract

Section: Discussionsupporting

confidence: 86%

Skin Prick Test Results and Total IgE Levels of Asthma Patients in Zagazig University Hospital (2015-2019)

Salama¹,

Mahfouz²,

Sileem³

et al. 2022

The Egyptian Journal of Hospital Medicine

View full text Add to dashboard Cite

show abstract

“…In the study of Knight et al. 25 95% patients (84) with a positive SPT also had a positive in vitro test, whilst only 83% (1078/1302) with a positive SPT in our own study also had a positive in vitro test. Besides other factors these differences could be explained by two different in vitro test methods and different cut‐offs in the two studies.…”

Section: Discussioncontrasting

confidence: 41%

“…The results of grass pollen‐sensitized patients were compared with data generated by Knight et al. 25 Out of 99 sensitized patients, 84% (84) had positive test results employing both techniques, while 11 sensitizations were only diagnosed by in vitro and only four by SPT. In the study of Knight et al.…”

Section: Discussionmentioning

confidence: 99%

Allergy screening with extract‐based skin prick tests demonstrates higher sensitivity over in vitro molecular allergy testing

Gureczny

Heindl

Klug

et al. 2023

Clinical & Translational All

View full text Add to dashboard Cite

Background As extract‐based skin testing as well as in vitro tests for major allergens have their own advantages, both procedures are usually performed in routine settings. In times of shortages in medical staff and supplies, we asked ourselves, how many patients would be underdiagnosed, if only one test could be used. Methods In a retrospective analysis, we investigated a cohort of 2646 patients seen by a single physician in a large Austrian outpatient allergy clinic in 2018. Only patients with an allergen source‐specific history and pairs of extract‐based skin prick (SPT) and in vitro molecular allergy tests to major allergens were included. Results For all tested allergen sources, sensitivity was higher for SPT than for sIgE‐based molecular allergy testing. Concerning 1006 birch pollen‐allergic patients, 791 (78.6%) had positive results with both tests, while 153 (15.2%) only with the SPT and 62 (6.2%) only with the sIgE to Bet v1. The other allergen sources showed similar results: For house dust mite 816/1120 (72.9%), grass pollen 1077/1416 (76.1%) and cat 433/622 (69.6%) remained test‐positive with both procedures, whereas in 276 (24.6%), 224 (15.8%) and 173 (27.8%) times only the SPT and 28 (2.5%), 115 (8.1%) and 16 (2.6%) times only the sIgE to Der p1/2/23, Phl p1/5 and Fel d1 showed a positive result. Each comparison was statistically significant (each p < 0.0001, Chi‐squared test). Conclusions Screening for allergy with major molecular allergens has lower sensitivity when compared with extract‐based skin tests. A combination of both is required for an optimal sensitivity.

show abstract

“…Some studies use sIgE to define atopic status, instead of, or in addition to, SPT. There is generally good correlation between sIgE and SPT (>70% concordance), at least in high‐income country settings …”

Section: Discussionmentioning

confidence: 94%

“…There is generally good correlation between sIgE and SPT (>70% concordance), at least in high-income country settings. 50,51 Not all children with a positive SPT will develop clinical symptoms of eczema, hay fever or allergic asthma. Some non-atopic children may develop different types of asthma caused by non-atopic mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Age at cytomegalovirus, Epstein Barr virus and varicella zoster virus infection and risk of atopy: The Born in Bradford cohort, UK

Pembrey

Waiblinger

Griffiths

et al. 2019

Pediatric Allergy Immunology

View full text Add to dashboard Cite

Background The prevalence of allergic diseases has increased in recent decades, but the causes remain unclear. Changes in the epidemiology of childhood infections could have contributed, but the current evidence is inconclusive. This study aims to investigate whether age at cytomegalovirus (CMV), Epstein‐Barr virus (EBV) or varicella zoster virus (VZV) infection is associated with the development of atopy. Methods A total of 2559 children were enrolled in the Born in Bradford Allergy and Infection Study. Serum samples collected at 12 and 24 months were tested for CMV‐IgG, EBV‐IgG and VZV‐IgG for 1000 children to establish age at infection. Skin prick testing (SPT) was conducted at age 4 years. Results Serology and SPT results were available for 740 children. Of these, 135 (18%) were atopic. In girls, there was a strong association of CMV infection in the second year with increased odds of atopy (adjusted OR 4.38, 95% CI 1.87‐10.29) but this was not observed in boys. Age at EBV or VZV infection was not associated with risk of atopy in unadjusted analysis, but there was effect modification by sex; girls infected with VZV in the second year of life had increased odds of atopy (adjusted OR 2.85, 95% CI 1.29‐6.30). Conclusions Our results highlight potential sex‐specific effects of age at CMV infection and age at VZV infection on risk of atopy, which provide insight into the mechanisms involved in the development of atopy.

show abstract

A comparison of specific IgE and skin prick test results to common environmental allergens using the HYTEC™ 288

Cited by 8 publications

References 12 publications

Skin Prick Test Results and Total IgE Levels of Asthma Patients in Zagazig University Hospital (2015-2019)

Skin Prick Test Results and Total IgE Levels of Asthma Patients in Zagazig University Hospital (2015-2019)

Allergy screening with extract‐based skin prick tests demonstrates higher sensitivity over in vitro molecular allergy testing

Age at cytomegalovirus, Epstein Barr virus and varicella zoster virus infection and risk of atopy: The Born in Bradford cohort, UK

Contact Info

Product

Resources

About